DRSC/TRiP Functional Genomics Resources

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Protein Alignment RanBP3 and RGPD2

DIOPT Version :10

Sequence 1:NP_651178.1 Gene:RanBP3 / 42804 FlyBaseID:FBgn0039110 Length:449 Species:Drosophila melanogaster
Sequence 2:XP_054199708.1 Gene:RGPD2 / 729857 HGNCID:32415 Length:1913 Species:Homo sapiens


Alignment Length:460 Identity:95/460 - (20%)
Similarity:156/460 - (33%) Gaps:130/460 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 FRGGFTLKASRLGGAVLRPAVLANSSGSNNSS--TSPSAGEDSALLNNPFLRESKDDDDDEEVVA 76
            ::|..|...:.|..|...|:|..:.|.:.||.  ..|:|                      .|..
Human  1005 YQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAA----------------------NVTP 1047

  Fly    77 T-GSAAAESTGDKEDDDVDERPDPLTKLRSNGIERSSMFAAAKNNMPNVQSSGFVFGQNVHERVV 140
            | ||:..|....||.                       |:.|      |.:.||.||      :.
Human  1048 TKGSSNTEFKSTKEG-----------------------FSIA------VSADGFKFG------IS 1077

  Fly   141 AP-NAEQVTAEP---DADTAASSVSAQE-------AASSST------AATSSSAPLLFSSVIQNA 188
            .| |.|:.:.:|   |....|..:|.|:       ..:|||      |.::|.....|.....|.
Human  1078 EPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDPNF 1142

  Fly   189 AQTTETSEAAASSSICSSSSNNKESAEAKSLTDVAREYEES-----RAQKRKYEEVETFTGEEDE 248
            ...:...|...||. |...:|...::......|.|.:.|:|     ....:..|:||..||||.|
Human  1143 KGFSGAGEKLFSSQ-CGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEGE 1206

  Fly   249 INIIDVSCKLFAF--LNSNWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAE 311
            ..:.....|||.|  ..|.|:|||.|:|::. ..::.|..|::.|....|::..|..:...|   
Human  1207 KVLYSQGVKLFRFDAEISQWKERGLGNLKIL-KNEVNGKPRMLMRRDQVLKVCANHWITTTM--- 1267

  Fly   312 RASQKSLRLTAIDNSGVVKIFLAMGRPADIAQLHKALSE----RIAKRKVSHPEECS-------- 364
                   .|..:..|....::||.......|:|.:..::    .:|:......|||.        
Human  1268 -------NLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPL 1325

  Fly   365 ------------------VEEAKNGVASEAAASLQPESTTHDDEDEDAAPGPSGA----ISAEAD 407
                              .||.|:|:..........::...::|::.:..|.:||    |....:
Human  1326 QTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPE 1390

  Fly   408 SYGPS 412
            :.||:
Human  1391 NTGPT 1395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RanBP3NP_651178.1 RanBD_RanBP3 243..352 CDD:270001 28/114 (25%)
RGPD2XP_054199708.1 Apc1_MidN 91..>206 CDD:466667
LapB <189..378 CDD:442196
TPR repeat 215..245 CDD:276809
RanBD2_RanBP2-like 1201..1317 CDD:269998 31/126 (25%)
RanBD3_RanBP2-like 1498..1614 CDD:270204
Rab_bind 1791..1851 CDD:435531
GRIP 1854..1897 CDD:460221
Blue background indicates that the domain is not in the aligned region.

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