DRSC/TRiP Functional Genomics Resources

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Protein Alignment RanBP3 and RGPD6

DIOPT Version :10

Sequence 1:NP_651178.1 Gene:RanBP3 / 42804 FlyBaseID:FBgn0039110 Length:449 Species:Drosophila melanogaster
Sequence 2:NP_001116835.1 Gene:RGPD6 / 729540 HGNCID:32419 Length:1765 Species:Homo sapiens


Alignment Length:434 Identity:87/434 - (20%)
Similarity:160/434 - (36%) Gaps:78/434 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 FRGGFTLKASRLGGAVLRPAVLANSSGSNNS--------STSPSAGEDSALLNNPFLRESKDDDD 70
            ::|..|...:.|..|...|:|..:.|.:.||        :.:|:.|..    |..|  :|..:..
Human   855 YQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSS----NTEF--KSTKEGF 913

  Fly    71 DEEVVATG-SAAAESTGDKEDDDVDERPDPLTKLRSNGIERSSMFAAAKNNMPNVQSSGFVFGQN 134
            ...|.|.| .......|::|            |.|...:|..:.| .|::.....:..|.:||| 
Human   914 SIPVSADGFKFGISEPGNQE------------KKREKPLENDTGF-QAQDISGRKKGRGVIFGQ- 964

  Fly   135 VHERVVAPNAEQVTAEPDADTAASSVSAQEAASSSTAATSSSAPLLFSSVIQNAAQTTETSEAAA 199
                                |:::...|..|.|:|..........|.......|.:...:|....
Human   965 --------------------TSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGK 1009

  Fly   200 SSSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKYEEVETFTGEEDEINIIDVSCKLFAFLNS 264
            .::..::|.:.::..:|....|....:.|...|..  |:||..||||.|..:.....|||.|...
Human  1010 MANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMP--EKVELVTGEEGEKVLYSQGVKLFRFDAE 1072

  Fly   265 --NWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAE--RASQKSLRLTAID- 324
              .|:|||.|:|::. ..::.|..|::.|....|::..|..:...|..:  ..|.::...:|.| 
Human  1073 VRQWKERGLGNLKIL-KNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDF 1136

  Fly   325 NSGVVKI--FLAMGRPADIAQLHKALSERIAKRKVSHPEEC---------------SVEEAKNGV 372
            :.|..|:  ..|..:..::|:..|...|...:..:..|.:.               ..||.|:|:
Human  1137 SDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGL 1201

  Fly   373 ASEAAASLQPESTTHDDEDEDAAPGPSGA----ISAEADSYGPS 412
            ..........::...::|::.:..|.:||    |...|::.||:
Human  1202 KDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAENTGPT 1245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RanBP3NP_651178.1 RanBD_RanBP3 243..352 CDD:270001 30/115 (26%)
RGPD6NP_001116835.1 TPR 1 26..59
LapB <33..222 CDD:442196
TPR repeat 59..89 CDD:276809
TPR 2 60..93
TPR 3 648..681
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..804
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 924..945 5/32 (16%)
RanBD2_RanBP2-like 1051..1167 CDD:269998 30/116 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1214..1247 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1306..1330
RanBD3_RanBP2-like 1348..1464 CDD:270204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1621
Rab_bind 1641..1705 CDD:435531
GRIP 1706..1749 CDD:460221
Blue background indicates that the domain is not in the aligned region.

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