DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanBP3 and FAM111A

DIOPT Version :9

Sequence 1:	NP_651178.1	Gene:	RanBP3 / 42804	FlyBaseID:	FBgn0039110	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001135991.1	Gene:	FAM111A / 63901	HGNCID:	24725	Length:	611	Species:	Homo sapiens

Alignment Length:	108	Identity:	28/108 - (25%)
Similarity:	38/108 - (35%)	Gaps:	34/108 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 LTAIDNSGVVKIFLAMGRP----------ADIAQLHKA--LSERIAKRKVSHPEECSVEEAKNGV 372
            :|.:..||::.|   :|.|          |.|.|..:|  ..||:..:|...||.         |
Human   460 ITPVPLSGLIHI---IGHPYGEKKQIDACAVIPQGQRAKKCQERVQSKKAESPEY---------V 512

  Fly   373 ASEAAASLQ-----PESTTHDDEDEDAAPGPSGAISAEADSYG 410
            ......|.|     |:..|:|.|....|.|     |...||.|
Human   513 HMYTQRSFQKIVHNPDVITYDTEFFFGASG-----SPVFDSKG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBP3	NP_651178.1	RanBD_RanBP3	243..352	CDD:270001	11/43 (26%)
FAM111A	NP_001135991.1	PIP-box. /evidence=ECO:0000269\|PubMed:24561620	16..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..73
		Interaction with SV40 large T antigen. /evidence=ECO:0000269\|PubMed:23093934	336..611		28/108 (26%)
		Trypsin_2	370..555	CDD:379142	28/108 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900