DRSC/TRiP Functional Genomics Resources

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Protein Alignment RanBP3 and RGPD4

DIOPT Version :10

Sequence 1:NP_651178.1 Gene:RanBP3 / 42804 FlyBaseID:FBgn0039110 Length:449 Species:Drosophila melanogaster
Sequence 2:NP_872394.2 Gene:RGPD4 / 285190 HGNCID:32417 Length:1758 Species:Homo sapiens


Alignment Length:455 Identity:93/455 - (20%)
Similarity:159/455 - (34%) Gaps:96/455 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 TSPSAGEDSALLNNPFLRESK--DDDDDEEVVATGSAAAESTGDKEDDDVDERPD---------- 98
            |.|...||...|.....:|.|  .::..|..:.:..:|:......|:...|..||          
Human   800 TPPRWAEDQNSLLKMIRQEVKAIKEEMQELKLNSSKSASHHRWPTENYGPDSVPDGYQGSQTFHG 864

  Fly    99 -PLTKL---------RSNGIERSSMFAAAKNNMPN------------------VQSSGFVFGQNV 135
             |||..         :|.......:...|.|..|.                  |.:.||.||   
Human   865 APLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIPVSADGFKFG--- 926

  Fly   136 HERVVAP-NAEQVTAEP---DADTAASSVSAQE-------AASSST------AATSSSAPLLFSS 183
               :..| |.|:.:.:|   |....|..:|.|:       ..:|||      |.::|.....|..
Human   927 ---ISEPGNQEKESEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGK 988

  Fly   184 VIQNAAQTTETSEAAASSSICSSSSNNKESAEAKSLTDVAREYEES-----RAQKRKYEEVETFT 243
            ...|....:...|...||. |...:|...::......|.|.:.|:|     ....:..|:||...
Human   989 KDPNFKGFSGAGEKLFSSQ-CGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVI 1052

  Fly   244 GEEDEINIIDVSCKLFAFLNS--NWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWA 306
            |||.|..:.....|||.|...  .|:|||.|:|::. ..::.|..|::.|....|::..|..:..
Human  1053 GEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKIL-KNEVNGKPRMLMRREQVLKVCANHWITT 1116

  Fly   307 AMVAE--RASQKSLRLTAID-NSGVVKI--FLAMGRPADIAQLHKALSERIAKRKVSHPEEC--- 363
            .|..:  ..|.::...:|.| :.|..|:  ..|..:..::|:..|...|...:..:..|.:.   
Human  1117 TMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQQLLLDIPLQTPHK 1181

  Fly   364 ------------SVEEAKNGVASEAAASLQPESTTHDDEDEDAAPGPSGA----ISAEADSYGPS 412
                        ..||.|:|:..........::...::|::.:..|.:||    |....::.||:
Human  1182 LVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPT 1246

  Fly   413  412
            Human  1247  1246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RanBP3NP_651178.1 RanBD_RanBP3 243..352 CDD:270001 29/115 (25%)
RGPD4NP_872394.2 LapB <33..222 CDD:442196
TPR repeat 59..89 CDD:276809
TPR 1 60..93
TPR 2 584..617
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..805 2/4 (50%)
RanBD2_RanBP2-like 1053..1168 CDD:269998 29/115 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1213..1249 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1295..1332
RanBD3_RanBP2-like 1349..1465 CDD:270204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1583..1621
Rab_bind 1642..1706 CDD:435531
GRIP 1707..1750 CDD:460221
Blue background indicates that the domain is not in the aligned region.

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