DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanBP3 and nup61

DIOPT Version :9

Sequence 1:	NP_651178.1	Gene:	RanBP3 / 42804	FlyBaseID:	FBgn0039110	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_587937.2	Gene:	nup61 / 2539348	PomBaseID:	SPCC18B5.07c	Length:	549	Species:	Schizosaccharomyces pombe

Alignment Length:	400	Identity:	96/400 - (24%)
Similarity:	161/400 - (40%)	Gaps:	97/400 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ASRLGGAVLRPAVLANSSGSNNSSTSP--SAGEDSALLNNPFLRESKDDDDDEEVVATGSAAAES 84
            |.|.|.:.  || |.:|...|:|:.:|  |.||.||.     ..|:|:.:......|||:||..:
pombe   186 APRFGFSA--PA-LGSSFQFNSSAFTPKGSFGEKSAT-----EAEAKEKETSSNQTATGTAATTT 242

  Fly    85 T-------------GDKEDDDVDERPDPLTKLRSNGIERSSMFAA-------------AKNNMP- 122
            .             ..||    :|...|||.:.|.....:|..|:             ::.:.|
pombe   243 NQFSFNTAANPFAFAKKE----NEESKPLTPVFSFSTTMASADASKETKQTHETKDSKSEESKPS 303

  Fly   123 NVQSSGFVFGQNVHERVVAP---NAEQVTAEPDAD----------TAASSVSAQEAASSSTAATS 174
            |.:.|         |..|.|   |....:..||..          |..:.:|:::..:||.....
pombe   304 NNEKS---------ENAVEPAKGNTMSFSWTPDKPIKFDTPEKKFTFTNPLSSKKLPASSDVKPP 359

  Fly   175 SSAPLLFSSVIQNAAQTTETSEAAASSSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKYEEV 239
            |:|.:.||.    ...|...|.||..||..:||:.....||        :..|.|...|.:.||.
pombe   360 SAAAVGFSF----GTTTNPFSFAAPKSSFPTSSTPASVGAE--------KSEETSNGNKSEQEEK 412

  Fly   240 ETFT---------------GEEDEINIIDVSCKLFAF--LNSNWEERGRGSLRLNDAKDLRGDSR 287
            |...               |||:|.::.:...|::.|  .:.::.:.|.|.|::|..:| .|.:|
pombe   413 ENGNDETRSNDSLVSGKGKGEENEDSVFETRAKIYRFDATSKSYSDIGIGPLKINVDRD-TGSAR 476

  Fly   288 VVFRTSGNLRLLLNTKVWAAMVAERASQKSLRLTAIDNSG-VVKIFLAMGRPADIAQLHKALSER 351
            ::.|..|:.:||||.::........|.:|.:::.|....| .::::|...:....|:  |.|:|
pombe   477 ILARVEGSGKLLLNVRLCQDFEYSLAGKKDVKVPAASTDGKSIEMYLIRVKEPSTAE--KLLAE- 538

  Fly   352 IAKRKVSHPE 361
            :.::|||..|
pombe   539 LNEKKVSKSE 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBP3	NP_651178.1	RanBD_RanBP3	243..352	CDD:270001	28/126 (22%)
nup61	NP_587937.2	NUP50	3..63	CDD:286055
nup61	NP_587937.2	RanBD_NUP50	431..543	CDD:269991	28/115 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001968
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3882
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840