DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmgcr and HMG1

DIOPT Version :9

Sequence 1:NP_732900.1 Gene:Hmgcr / 42803 FlyBaseID:FBgn0263782 Length:920 Species:Drosophila melanogaster
Sequence 2:NP_013636.1 Gene:HMG1 / 854900 SGDID:S000004540 Length:1054 Species:Saccharomyces cerevisiae


Alignment Length:873 Identity:319/873 - (36%)
Similarity:474/873 - (54%) Gaps:97/873 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 DVILMTIVRCTAVLYCYYQ----FCSLHRLGSKYVLGIAGLFTVFSSF---IFTTAIIKFLGSDI 163
            ||::|.    ||.|..:|.    |..:.:.||.:.|..:.:....||.   ::.|..|  ||.::
Yeast   189 DVLIMV----TAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQCI--LGKEV 247

  Fly   164 SELK--DALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIARGLELLGPAISLD---TIVEVLL 223
            |.|.  :.|.|:::|:...:..::||.||....:..:::.|... |::..::|.:   .|.:.||
Yeast   248 SALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTD-EIVFESVSEEGGRLIQDHLL 311

  Fly   224 ---VGVGTLSGVQRLEVLCMFAVLSVLV---NYVVFMTFYPACLSLIFDLS---RSGVDMSVVRE 279
               ..:|......:|:.|..|.:||..:   ..::..|||.|.|:|..:::   ||.:....:.|
Yeast   312 CIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLEMNVIHRSTIIKQTLEE 376

  Fly   280 KAKGSLLLKSLTEEEQKA-----NPVLQRVKLIMTTGLMAVHIYSRV----------AFSGSDYD 329
            ........:.:::.|:|:     |  |..|.:||...::.:.::...          ||:...:|
Yeast   377 DGVVPSTARIISKAEKKSVSSFLN--LSVVVIIMKLSVILLFVFINFYNFGANWVNDAFNSLYFD 439

  Fly   330 AVDKTLTPTLSLNVSNNRTESG-----------------EIADIIIKWL----TMSADHIVISIV 373
            ....:|...::.|.|.|..|..                 .|.|:::..|    ....|..|..:|
Yeast   440 KERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVLLLLRNVSVAIRDRFVSKLV 504

  Fly   374 LIALVVKFI--------CFDNRDPLPDQLRQSGPVAIAAKASQTTPIDEEH--VEQEKDTENSAA 428
            |.|||...:        ...:.....|||.::.    ..|.|.|.|:.:..  |...|...:.:.
Yeast   505 LSALVCSAVINVYLLNAARIHTSYTADQLVKTE----VTKKSFTAPVQKASTPVLTNKTVISGSK 565

  Fly   429 VRTLLFTIEDQSSANASTQTDLLPLRHRLVGPI-KPPRPVQECLDILNSTEEGSGPAALSDEEIV 492
            |::|.......|..::|::.|    ..|.:..: |..||::|...:|:|    .....|.::|:.
Yeast   566 VKSLSSAQSSSSGPSSSSEED----DSRDIESLDKKIRPLEELEALLSS----GNTKQLKNKEVA 622

  Fly   493 SIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENV 557
            ::|..|  ..||:.:|..|.|..|.|.:||:.:...|:.||...|.|||:::||.:|..||||||
Yeast   623 ALVIHG--KLPLYALEKKLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENV 685

  Fly   558 LGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSV-RGVRSVVEDVGMTRAPCVR 621
            :||:|:|||..|||::||.:|::|||||||.||||..|||||::. .|..:|:...||||.|.||
Yeast   686 IGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVR 750

  Fly   622 FPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMV 686
            ||::.|:...|.|::::|....:|..|:|||||.||:.....:.|..|::||...|||||||||:
Yeast   751 FPTLKRSGACKIWLDSEEGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMI 815

  Fly   687 SKGAEMALRRI--QLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKT 749
            |||.|.:|:::  :..:.||:::|:|||:|.||||||||||:||||.||.|.||....:|.|||:
Yeast   816 SKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKS 880

  Fly   750 DAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENS 814
            |...|||.|..||:.|||||||:||.||||||:|||||||.||||||||.||||.|.|:   |..
Yeast   881 DVSALVELNIAKNLVGSAMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMK---EVD 942

  Fly   815 EDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSL 879
            .||.::.:|||:||||:||||.|..|.|.|::|||||.|||.||.||::||:||...|:||||||
Yeast   943 GDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSL 1007

  Fly   880 MAALVNSDLVKSHMRHNRSSIAVNSANN 907
            .|||....||:|||.|||........||
Yeast  1008 CAALAAGHLVQSHMTHNRKPAEPTKPNN 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmgcrNP_732900.1 2A060605 1..920 CDD:273339 319/873 (37%)
MMPL 133..263 CDD:304422 34/143 (24%)
HMG-CoA_reductase_classI 489..897 CDD:153081 221/410 (54%)
HMG1NP_013636.1 HPIH 10..161 CDD:404239
2A060605 189..1025 CDD:273339 315/861 (37%)
HMG_CoA_R_NADP 616..1025 CDD:129624 222/413 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345786
Domainoid 1 1.000 423 1.000 Domainoid score I74
eggNOG 1 0.900 - - E1_COG1257
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H30994
Inparanoid 1 1.050 463 1.000 Inparanoid score I235
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002934
OrthoInspector 1 1.000 - - otm46483
orthoMCL 1 0.900 - - OOG6_101762
Panther 1 1.100 - - LDO PTHR10572
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R563
SonicParanoid 1 1.000 - - X1935
TreeFam 1 0.960 - -
1312.780

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