DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmgcr and HMG2

DIOPT Version :9

Sequence 1:	NP_732900.1	Gene:	Hmgcr / 42803	FlyBaseID:	FBgn0263782	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_013555.1	Gene:	HMG2 / 851171	SGDID:	S000004442	Length:	1045	Species:	Saccharomyces cerevisiae

Alignment Length:	890	Identity:	307/890 - (34%)
Similarity:	477/890 - (53%)	Gaps:	116/890 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 AEYNAADVILMTIVRCTAVLYCYYQFCSL----HRLGSKYVLGIAGL----FTVFSSFIFTTAII 156
            :|::..|:.::    ..|.|..:|..|.|    .::|||:.|..:.|    ..::.|...|.:::
Yeast   182 SEFDQFDLFII----LAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLL 242

  Fly   157 KFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIA------RGLELLGPAISL 215
            |...|.:| |...|.|::::|...:..|||..:|...::..:.:.|.      ..:...|..:..
Yeast   243 KKPASLLS-LVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIR 306

  Fly   216 DTIVEVLLVGVGTLSGVQRLEVLCMFAVLS---VLVNYVVFMTFYPACLSLIFDLS---RSGVDM 274
            |.:..:... :|.....:.|..|..|.:||   ::.:.::..|||.|.||:..:::   ||.|..
Yeast   307 DYLFYISSF-IGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIR 370

  Fly   275 SVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTG-------LMAVHIYSRVAFSGSDYDAVD 332
            ..:.|..........:.::|..:.|...|..:.:..|       |:.:::|   .|:    |.::
Yeast   371 QTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLY---VFT----DKLN 428

  Fly   333 KTLTPTL-------SLNVSNNRTESGEIADIII-------KWLTMSADHIVISIVLIALVVKFIC 383
            .|:..|:       ||....|..:.|.:::.:|       .:..:...|.:...||  |::..:.
Yeast   429 ATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKKYHQIEDSVL--LIIDSVS 491

  Fly   384 FDNRDPLPDQL---RQSGPVAI------AAK--------ASQTTPIDEEHVEQEKDTENSAAVRT 431
            ...||....:|   ..:..::|      |||        ..|:..||:..|:|:..|...:..|:
Yeast   492 NAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSNKIDDLVVQQKSATIEFSETRS 556

  Fly   432 LLFTIEDQSSANASTQT-----DLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAA------ 485
            :        .|::..:|     |::         |.......||:..|:|.:|...|.:
Yeast   557 M--------PASSGLETPVTAKDII---------ISEEIQNNECVYALSSQDEPIRPLSNLVELM 604

  Fly   486 -------LSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEH 543
                   :::.|:.::|..|  ..||:.:|..|:|..|.|.:||:.:.:.|:.|:...:.||:.:
Yeast   605 EKEQLKNMNNTEVSNLVVNG--KLPLYSLEKKLEDTTRAVLVRRKALSTLAESPILVSEKLPFRN 667

  Fly   544 FDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSV-RGVRS 607
            :||.:|..||||||:||:|||||..|||::||.:|::|||||||.||||..|||||::. .|..:
Yeast   668 YDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATT 732

  Fly   608 VVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIR 672
            |:...||||.|.||||::.|:...|.|::::|....:|..|:|||||.||:.....:.|..|::|
Yeast   733 VLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFNSTSRFARLQHIQTCLAGDLLFMR 797

  Fly   673 FVAITGDAMGMNMVSKGAEMALRRI--QLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTE 735
            |...|||||||||:|||.|.:|:::  :..:.||:::|:|||:|.||||||||||:||||.||.|
Yeast   798 FRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAE 862

  Fly   736 CTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTS 800
            .||....::||||:|...|||.|..||:.|||||||:||.||||||:|||:|||.||||||||.|
Yeast   863 ATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNAHAANLVTALFLALGQDPAQNVES 927

  Fly   801 SNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLA 865
            |||.|.|:   |...||.::.:|||:||||:||||.|..|.|.|::|||||.|.|.||.||::||
Yeast   928 SNCITLMK---EVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLA 989

  Fly   866 QIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSANNPLN 910
            :|:...|:||||||.:||....||:|||.|||.:...|....|.|
Yeast   990 RIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANELPQPSN 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	307/890 (34%)
		MMPL	133..263	CDD:304422	31/142 (22%)
		HMG-CoA_reductase_classI	489..897	CDD:153081	215/410 (52%)
HMG2	NP_013555.1	HPIH	10..159	CDD:404239
		2A060605	195..1030	CDD:273339	303/867 (35%)
		HMG_CoA_R_NADP	612..1021	CDD:129624	215/413 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345787
Domainoid	1	1.000	423	1.000	Domainoid score	I74
eggNOG	1	0.900	-	-		E1_COG1257
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30994
Inparanoid	1	1.050	463	1.000	Inparanoid score	I235
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002934
OrthoInspector	1	1.000	-	-		otm46483
orthoMCL	1	0.900	-	-		OOG6_101762
Panther	1	1.100	-	-	O	PTHR10572
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R563
SonicParanoid	1	1.000	-	-		X1935
TreeFam	1	0.960	-	-
	13	12.780