DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmgcr and HMG2

DIOPT Version :9

Sequence 1:	NP_732900.1	Gene:	Hmgcr / 42803	FlyBaseID:	FBgn0263782	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_179329.1	Gene:	HMG2 / 816244	AraportID:	AT2G17370	Length:	562	Species:	Arabidopsis thaliana

Alignment Length:	452	Identity:	227/452 - (50%)
Similarity:	301/452 - (66%)	Gaps:	26/452 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 DLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDD 513
            ::||::   ...:.|||..:     |:|.|         |||||.:| ..|| .|.:.:|:.|.|
plant   125 EVLPIK---PNSVDPPRESE-----LDSVE---------DEEIVKLV-IDGT-IPSYSLETKLGD 170

  Fly   514 PERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETY 578
            .:|...|||:.:   .::....|..||.|.|||..:|..|||..:|||.||||.||||||||..|
plant   171 CKRAAAIRREAV---QRITGKSLTGLPLEGFDYNSILGQCCEMPVGYVQIPVGIAGPLLLDGVEY 232

  Fly   579 YVPMATTEGALVASTNRGCKALSVR-GVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYR 642
            .||||||||.||||||||.||:.:. |..||:....|||||.|||||..|||....::::..|:.
plant   233 SVPMATTEGCLVASTNRGFKAIHLSGGAFSVLVKDAMTRAPVVRFPSARRAALVMFYLQDPSNFE 297

  Fly   643 VVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQII 707
            .:...|:.:|||.||:.....:.|..||.||...|||||||||||||.:..|..::.:||||.:|
plant   298 RLSLIFNKSSRFARLQSITCTIAGRNLYPRFACSTGDAMGMNMVSKGVQNVLDFVKSEFPDMDVI 362

  Fly   708 SLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSI 772
            .:|||:|.|||.:|:|||:||||.||.|..|.|..:..||||..:.|||.|.|||:.|||||||:
plant   363 GISGNYCSDKKASAVNWIEGRGKHVVCEAFIKAEIVEKVLKTSVEALVELNTLKNLVGSAMAGSL 427

  Fly   773 GGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGL 837
            ||.|||::|:|:|||:||||||||||.||:|.|.:   ..:.:||:::.:||.:|||||||||.|
plant   428 GGFNAHSSNIVSAVFIATGQDPAQNVESSHCMTMI---LPDGDDLHISVSMPCIEVGTVGGGTQL 489

  Fly   838 PGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSS 899
            ..|:|||.:|||:|::..:||.||::||:||..:|:|||||||:|:....||||||::||||
plant   490 ASQAACLNLLGVKGSNNEKPGSNAQQLARIVAGSVLAGELSLMSAIAAGQLVKSHMKYNRSS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	227/452 (50%)
		MMPL	133..263	CDD:304422
		HMG-CoA_reductase_classI	489..897	CDD:153081	214/408 (52%)
HMG2	NP_179329.1	HMG-CoA_reductase_classI	148..549	CDD:153081	214/408 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	410	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_COG1257
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30994
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D907394at2759
OrthoFinder	1	1.000	-	-		FOG0002934
OrthoInspector	1	1.000	-	-		otm3565
orthoMCL	1	0.900	-	-		OOG6_101762
Panther	1	1.100	-	-	O	PTHR10572
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1935
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780