DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmgcr and hmgcra

DIOPT Version :9

Sequence 1:	NP_732900.1	Gene:	Hmgcr / 42803	FlyBaseID:	FBgn0263782	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_001073446.2	Gene:	hmgcra / 559054	ZFINID:	ZDB-GENE-040401-2	Length:	884	Species:	Danio rerio

Alignment Length:	950	Identity:	423/950 - (44%)
Similarity:	600/950 - (63%)	Gaps:	120/950 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDK---NNTLDASSGLGTATASAAAAGGSGSG 62
            |:.||||.||.|.||||||||||.:|:|.||::::.   ||.:
Zfish     1 MLTRLFRIHGLFVASHPWEVIVATVTLTICMMSMNMFTGNNQI---------------------- 43

  Fly    63 AGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCS 127
                                     | ||:..|..|:.:..::|:|::||.||.|::|.|:||.:
Zfish    44 -------------------------C-GWNFDCPKLDEQILSSDIIILTITRCIAIVYIYFQFQN 82

  Fly   128 LHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSG 192
            |.:|||||:||||||||:||||:|:|.:|.||..:::.|.:||.|.||:||||.:..||:.|||.
Zfish    83 LRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKACALAKFALSS 147

  Fly   193 SNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFY 257
            ::|.||.:|||:|:.:|||..:||.:||.|::||||:|||::||::|.|..:|||.||.|||||:
Zfish   148 NSQDEVRENIAKGMAVLGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFF 212

  Fly   258 PACLSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSR-V 321
            |||:||:.:|||...:...:.:.:..:.:|:.  ||:.|.|||.||||:||:.||:.||.:|| :
Zfish   213 PACVSLVLELSRESREGRPIWQLSHFARVLEE--EEDNKPNPVTQRVKMIMSLGLVMVHAHSRWI 275

  Fly   322 AFSGSDYDAVDKTLTPTLSLNVSNNRTESGEIADI------IIKWLTMSADHIVISIVLIALVVK 380
            |...|....:|   .|.:.::::.|..:..| .|:      :.:.::|..:.::...:.:.|.||
Zfish   276 ADPASSDGTLD---LPEVGMSLNENLPKRIE-PDMPLWHFYLSRMISMDIEQVITLGLALFLAVK 336

  Fly   381 FICFDN---------RDPLPDQL-----------RQSGPVAIAAKASQTTP--IDEEHVEQEKDT 423
            :|.|:.         :.|.|..:           |:..|.:.......|.|  :.:|
Zfish   337 YIFFEQVEMESTLSLKVPTPSSMLTQKWSPDQCCRKEIPYSTKLDKPPTPPPVVTKE-------- 393

  Fly   424 ENSAAVRTL----------LFTI-EDQSSANASTQTDLLPLRHRLVGPIKPPRPVQECLDILNST 477
            |....:|.|          .|.: ||::..|......::.|      |.: ||||::||.||.:.
Zfish   394 ERDLVIRPLPAPKEPEQKSTFVLGEDETQENTHVPEPVMSL------PAE-PRPVEDCLSILKNP 451

  Fly   478 EEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYE 542
            :.|:  ..|||||::.:|::  .|.|.:|:|::::.|||||.|||:::..:...| ..|..|||:
Zfish   452 DMGA--RYLSDEEVIVLVNS--KHIPAYKLEAMMETPERGVMIRRKMLSPKFPEP-STLSCLPYK 511

  Fly   543 HFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVRS 607
            .:||.||:..|||||:||:|:|||.||||||||:.:.||||||||.|||||||||:|:::.|..|
Zfish   512 DYDYSKVMGTCCENVIGYMPVPVGVAGPLLLDGKQFQVPMATTEGCLVASTNRGCRAIALAGGAS 576

  Fly   608 --VVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLY 670
              |:.| ||||.|.|||||..:|||.|:|:|:.|.::.:|..||.||||.||:...|.:....||
Zfish   577 SRVLAD-GMTRGPVVRFPSACQAAEVKAWLESPEGFKTIKEAFDQTSRFARLEKLLIGLASRNLY 640

  Fly   671 IRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTE 735
            |||.:.|||||||||:|||.|.||.|::.:||::|::::|||:|.||||||||||:||||.||.|
Zfish   641 IRFQSRTGDAMGMNMISKGTEQALARLKEEFPELQVLAVSGNYCTDKKPAAINWIEGRGKSVVCE 705

  Fly   736 CTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTS 800
            .||.|..::.:|||..:.||:.|..||:.||||||||||.||||||:|.|:::|.||||||.|.|
Zfish   706 TTIPAKVVKEILKTSTEALVDVNISKNLVGSAMAGSIGGYNAHAANIVAAIYIACGQDPAQTVGS 770

  Fly   801 SNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLA 865
            |||.|.||......||||::|||||:|:|||||||.||.|.|||:||||.||....||:||::||
Zfish   771 SNCITLMEASGATGEDLYISCTMPSIELGTVGGGTNLPPQQACLKMLGVLGASQECPGENARQLA 835

  Fly   866 QIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSA 905
            ::|||||:|||||||:||....||||||.||||.:.:..|
Zfish   836 KVVCATVLAGELSLMSALAAGHLVKSHMTHNRSKVNLQEA 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	422/949 (44%)
		MMPL	133..263	CDD:304422	74/129 (57%)
		HMG-CoA_reductase_classI	489..897	CDD:153081	237/409 (58%)
hmgcra	NP_001073446.2	2A060605	1..884	CDD:273339	422/949 (44%)
		MMPL	88..218	CDD:304422	74/129 (57%)
		HMG-CoA_reductase_classI	461..867	CDD:153081	237/409 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593616
Domainoid	1	1.000	168	1.000	Domainoid score	I3793
eggNOG	1	0.900	-	-		E1_COG1257
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30994
Inparanoid	1	1.050	746	1.000	Inparanoid score	I560
OMA	1	1.010	-	-		QHG45219
OrthoDB	1	1.010	-	-		D251672at33208
OrthoFinder	1	1.000	-	-		FOG0002934
OrthoInspector	1	1.000	-	-		otm25835
orthoMCL	1	0.900	-	-		OOG6_101762
Panther	1	1.100	-	-	LDO	PTHR10572
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R563
SonicParanoid	1	1.000	-	-		X1935
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800