Protein Alignment Hmgcr and hmgr-1

DIOPT Version :10

• Sequence 1: NP_732900.1
• Gene: Hmgcr / 42803
• FlyBaseID: FBgn0263782
• Length: 920
• Species: Drosophila melanogaster
• Sequence 2: NP_498626.2
• Gene: hmgr-1 / 176047
• WormBaseID: WBGene00017268
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 505
• Identity: 222/505 - (43%)
• Similarity: 296/505 - (58%)
• Gaps: 50/505 - (9%)

  Fly   412 IDEEHVEQEKDTENSAAVRTLLFTI-EDQSSANASTQTDLLPLRHRLVGPIKPP-RPVQECLDIL 474
            |.|.:.::||..      |..||:: ||..|             ...|.|||.. ....:|...:
 Worm    29 ICENYDQKEKPK------RKPLFSVGEDDDS-------------EEYVSPIKETCETGTQCKRDV 74

  Fly   475 NSTEEGSGPAALSDE--------------EIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQII 525
            ...|..||..:| ||              |.|.::..|  .....::||.. ..|:.:.|||..|
 Worm    75 EYPEIESGNRSL-DEISREWKECKDVTPGEAVRLLRRG--QAKSRELESRF-PAEQAIPIRRTFI 135

  Fly   526 GSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGET-YYVPMATTEGAL 589
            ..       :.:.|||..:||......|||||:||.|:|||.||||.|:|.: .|||||||||||
 Worm   136 NK-------KFENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIYVPMATTEGAL 193

  Fly   590 VASTNRGCKAL-SVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSR 653
            :||||||...: :..||.:.:.:.||||||.|:||:...|...|.|:|:.||....:.||.|.||
 Worm   194 IASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPENQDRARQEFQSCSR 258

  Fly   654 FGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKK 718
            |.:||...|.:||...|:||.|.|||||||||:||..:..:|.:...||:|.:::||||.|.|||
 Worm   259 FAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENFPEMTVLALSGNLCVDKK 323

  Fly   719 PAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMV 783
            .||.||.:|||:.||.||.|....:...|:|..:.|......|...||:.||::||:||||||:|
 Worm   324 AAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVGGSNAHAANIV 388

  Fly   784 TAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLG 848
            .|:|:|||||.||.|:||.|||.||..|:  ::||::||:|.:|||||||||.|..|.||||.||
 Worm   389 AAIFIATGQDAAQVVSSSMCSTRMEVTAD--KNLYVSCTLPCVEVGTVGGGTILAPQRACLESLG 451

  Fly   849 VRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRS 898
            ..|.:..:||.||::||:::.|||:||||||||||..::||.|||:.|||
 Worm   452 CAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNELVSSHMKLNRS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	222/505 (44%)
hmgr-1	NP_498626.2	HMG-CoA_reductase_classI	102..500	CDD:153081	198/409 (48%)