DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmgcr and hmgr-1

DIOPT Version :9

Sequence 1:	NP_732900.1	Gene:	Hmgcr / 42803	FlyBaseID:	FBgn0263782	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_498626.2	Gene:	hmgr-1 / 176047	WormBaseID:	WBGene00017268	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	222/505 - (43%)
Similarity:	296/505 - (58%)	Gaps:	50/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 IDEEHVEQEKDTENSAAVRTLLFTI-EDQSSANASTQTDLLPLRHRLVGPIKPP-RPVQECLDIL 474
            |.|.:.::||..      |..||:: ||..|             ...|.|||.. ....:|...:
Worm    29 ICENYDQKEKPK------RKPLFSVGEDDDS-------------EEYVSPIKETCETGTQCKRDV 74

  Fly   475 NSTEEGSGPAALSDE--------------EIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQII 525
            ...|..||..:| ||              |.|.::..|  .....::||.. ..|:.:.|||..|
Worm    75 EYPEIESGNRSL-DEISREWKECKDVTPGEAVRLLRRG--QAKSRELESRF-PAEQAIPIRRTFI 135

  Fly   526 GSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGET-YYVPMATTEGAL 589
            ..       :.:.|||..:||......|||||:||.|:|||.||||.|:|.: .|||||||||||
Worm   136 NK-------KFENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIYVPMATTEGAL 193

  Fly   590 VASTNRGCKAL-SVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSR 653
            :||||||...: :..||.:.:.:.||||||.|:||:...|...|.|:|:.||....:.||.|.||
Worm   194 IASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPENQDRARQEFQSCSR 258

  Fly   654 FGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKK 718
            |.:||...|.:||...|:||.|.|||||||||:||..:..:|.:...||:|.:::||||.|.|||
Worm   259 FAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENFPEMTVLALSGNLCVDKK 323

  Fly   719 PAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMV 783
            .||.||.:|||:.||.||.|....:...|:|..:.|......|...||:.||::||:||||||:|
Worm   324 AAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVGGSNAHAANIV 388

  Fly   784 TAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLG 848
            .|:|:|||||.||.|:||.|||.||..|:  ::||::||:|.:|||||||||.|..|.||||.||
Worm   389 AAIFIATGQDAAQVVSSSMCSTRMEVTAD--KNLYVSCTLPCVEVGTVGGGTILAPQRACLESLG 451

  Fly   849 VRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRS 898
            ..|.:..:||.||::||:::.|||:||||||||||..::||.|||:.|||
Worm   452 CAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNELVSSHMKLNRS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	222/505 (44%)
		MMPL	133..263	CDD:304422
		HMG-CoA_reductase_classI	489..897	CDD:153081	199/423 (47%)
hmgr-1	NP_498626.2	HMG-CoA_reductase_classI	102..500	CDD:153081	198/409 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165742
Domainoid	1	1.000	373	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG1257
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30994
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251672at33208
OrthoFinder	1	1.000	-	-		FOG0002934
OrthoInspector	1	1.000	-	-		oto17197
orthoMCL	1	0.900	-	-		OOG6_101762
Panther	1	1.100	-	-	LDO	PTHR10572
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R563
SonicParanoid	1	1.000	-	-		X1935
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740