DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmgcr and hmgcr

DIOPT Version :9

Sequence 1:NP_732900.1 Gene:Hmgcr / 42803 FlyBaseID:FBgn0263782 Length:920 Species:Drosophila melanogaster
Sequence 2:XP_002934890.2 Gene:hmgcr / 100380121 XenbaseID:XB-GENE-5840593 Length:883 Species:Xenopus tropicalis


Alignment Length:956 Identity:429/956 - (44%)
Similarity:587/956 - (61%) Gaps:143/956 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNTLDASSGLGTATASAAAAGGSGSGAGS 65
            |:.||||.||:|.|||||||||..:|:|.||:::                               
 Frog     1 MLSRLFRMHGQFVASHPWEVIVGTVTLTICMMSM------------------------------- 34

  Fly    66 GASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHR 130
                         :..:...:.| ||:.:|...|.:..::|:|::||.||.|:||.|:||.:|.:
 Frog    35 -------------NMFTGNDKIC-GWNYACPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQ 85

  Fly   131 LGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQ 195
            |||||:||||||||:||||:|:|.:|.||..:::.|.:||.|.||:||||.:..||:.|||.::|
 Frog    86 LGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKASALAKFALSSNSQ 150

  Fly   196 AEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFYPAC 260
            .||..|||||:.:|||..:||.:||.|::||||:|||::||::|.|..:|||.||..||||:|||
 Frog   151 DEVRDNIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFAFMTFFPAC 215

  Fly   261 LSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSRVAFSG 325
            :||:.:|||...:...:.:.::.:.:|:.  ||:.|.|||.||||:||:.||:.||.:||     
 Frog   216 VSLVLELSRESREGRPIWQLSQFASVLEE--EEDNKPNPVTQRVKMIMSLGLVLVHAHSR----- 273

  Fly   326 SDYDAVDKTLTPTLSLNVSNNRTESGE------IADIIIK--------W-------LTMSADHIV 369
                        .:|...|.|.|..|:      :.|::.|        |       :||..:.|:
 Frog   274 ------------WISEPSSQNSTSIGDHEVSTMLDDMMPKRVEPSMPLWQFYLSRMVTMDVEQII 326

  Fly   370 ISIVLIALVVKFICFDN---------RDPLPDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDT-- 423
            ...:.:.|.||:|.|:.         ::|:      ..|||:..|.:::....|.  ||||..  
 Frog   327 TLGLALLLAVKYIFFEQTETESTFSLKNPI------ISPVAVQKKQAESCCRREP--EQEKTVIV 383

  Fly   424 ----------ENSAAVRTL--------LFTIEDQSSANAS-----TQTDLLPLRHRLVGPIKPPR 465
                      |..|.:|.|        .|.:.|.|....|     |..||         | :.||
 Frog   384 SSTEDASSKEEKEAVIRPLPLETSPKAKFMVGDSSPVELSPEEKNTSFDL---------P-EEPR 438

  Fly   466 PVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAK 530
            |:.||:.||.:.::|:  ..|:|.|::|:|:|  .|.|.:|:|::::.|||||.:|||::..:..
 Frog   439 PLDECVRILKNPDKGA--QYLTDAEVISLVNA--KHIPAYKLETMMESPERGVAVRRQMLADKLP 499

  Fly   531 MPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNR 595
            .| ..|..|||::::|..|:.||||||:||:|||||.||||.|:.:.|.||||||||.|||||||
 Frog   500 QP-SALQSLPYKNYNYSLVMGACCENVIGYMPIPVGVAGPLFLNNKEYQVPMATTEGCLVASTNR 563

  Fly   596 GCKALSV-RGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKD 659
            ||:|:.: .|.||.|...||||.|.||.|:...|||.|:|:::.|.::|:|..|||||||.||..
 Frog   564 GCRAIMLGGGARSRVLADGMTRGPVVRLPTACDAAEVKAWLDSMEGFKVIKDAFDSTSRFARLGR 628

  Fly   660 CHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINW 724
            ....:.|..|||||.:.|||||||||:|||.|.||.|:|.:||::.::::|||:|.|||||||||
 Frog   629 LQTCVAGRNLYIRFQSKTGDAMGMNMISKGTEKALSRLQEEFPELHVLAVSGNYCTDKKPAAINW 693

  Fly   725 IKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLA 789
            |:||||.||.|..|.|..:|.|||:..:.|||.|..||:.||||||||||.||||||:|||:::|
 Frog   694 IEGRGKSVVCEAIIPARVVREVLKSSTEALVEVNINKNLIGSAMAGSIGGYNAHAANIVTAIYIA 758

  Fly   790 TGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHA 854
            .|||.||||.||||.|.||.....:||||::|||||:|:|||||||.|..|.|||:||||:||..
 Frog   759 CGQDAAQNVGSSNCITIMEATGPMNEDLYISCTMPSIEIGTVGGGTNLAPQQACLQMLGVQGAST 823

  Fly   855 TRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSI 900
            ..||.||.:||||||.|||||||||||||....||||||.||||.:
 Frog   824 EAPGKNACQLAQIVCGTVMAGELSLMAALAAGHLVKSHMVHNRSKM 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmgcrNP_732900.1 2A060605 1..920 CDD:273339 429/956 (45%)
MMPL 133..263 CDD:304422 74/129 (57%)
HMG-CoA_reductase_classI 489..897 CDD:153081 239/408 (59%)
hmgcrXP_002934890.2 2A060605 1..883 CDD:273339 429/956 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 453 1.000 Domainoid score I501
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H30994
Inparanoid 1 1.050 757 1.000 Inparanoid score I552
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D251672at33208
OrthoFinder 1 1.000 - - FOG0002934
OrthoInspector 1 1.000 - - oto102261
Panther 1 1.100 - - LDO PTHR10572
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1935
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.160

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