DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10300 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_651174.2	Gene:	CG10300 / 42798	FlyBaseID:	FBgn0039107	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	320	Identity:	61/320 - (19%)
Similarity:	119/320 - (37%)	Gaps:	69/320 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLDPKLAALAK--SECNEEQAQRA---------EIIATIKTWITKSPHLKAPTDEQLILAFLRRC 60
            ||.|.|.|::.  .:.:.:..:|.         ..:..::.|:.::...|.|.||. ||.|||..
Human   211 TLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKDEH-ILRFLRAH 274

  Fly    61 RFSQEETKRRFDNYYSLRSVFPEVLGSRQVD--------EALLTQLQRG---IHVIPMRPVSPEG 114
            .|..::.:.......|.|.       ..|||        .|||.:...|   ...|..||
Human   275 DFHLDKAREMLRQSLSWRK-------QHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRP----- 327

  Fly   115 PRVIISQFRNIDPK---KSNPREAFKLIFIMLELLAL------ECDNAA------ISGLIWVVDA 164
              :.|.:...:|.|   |:...||     ::..:|::      .|:.:.      ||....::|.
Human   328 --LYILRLGQMDTKGLMKAVGEEA-----LLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDL 385

  Fly   165 RDVTMEQMMQYDPFLLKKAFALVDQCIPLRFVEIHMINMRKEGQTIFNFVTKFLPSKLPFKFVVH 229
            ..:.|..:.:.....|.:...:|:...|.....:.::...:....::..::.|:......||:::
Human   386 EGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIY 450

  Fly   230 KKSE-----DLYQHLPRDVMTIEYGGTNGYQAEAVDHWRQKLLDSKD-YLAKDAQYGTNE 283
            ..|.     .|..:|.|:|:....||      |:|.:..:..|..|. |:.::.|..|::
Human   451 SGSNYQGPGGLVDYLDREVIPDFLGG------ESVCNVPEGGLVPKSLYMTEEEQEHTDQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10300	NP_651174.2	SEC14	95..251	CDD:238099	29/178 (16%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		2/2 (100%)
		CRAL_TRIO_N	243..288	CDD:215024	11/45 (24%)
		SEC14	306..479	CDD:214706	33/190 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810