DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10300 and TTPAL

DIOPT Version :9

Sequence 1:	NP_651174.2	Gene:	CG10300 / 42798	FlyBaseID:	FBgn0039107	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001034288.1	Gene:	TTPAL / 79183	HGNCID:	16114	Length:	342	Species:	Homo sapiens

Alignment Length:	283	Identity:	75/283 - (26%)
Similarity:	131/283 - (46%)	Gaps:	29/283 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLDPKLAALAKSECNEEQAQRAEIIATIKTWITKS-PHLKAPTDEQLILAFLRRCRFSQEETKRR 70
            :|...|...|:.|..|:...|...:..::..:.|. |:|....|:..:|.|||..:|..:...:.
Human    34 SLTEDLVTKAREELQEKPEWRLRDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQL 98

  Fly    71 FDNYYSLRSVFPEVLGSRQ-------VDEALLTQL----QRGIHVIPMRPVSPEGPRVIISQFRN 124
            ..||:|.|..:|||..:.:       :....||.|    .||.||:.:||     .|.|.|.:
Human    99 LVNYHSCRRSWPEVFNNLKPSALKDVLASGFLTVLPHTDPRGCHVVCIRP-----DRWIPSNY-- 156

  Fly   125 IDPKKSNPREAFKLIFIMLELLALECDNAAISGLIWVVDARDVTMEQMMQYDPFLLKKAFALVDQ 189
              |...|    .:.|::.||.| ::.:...::|::.:.|.:.|::.:...:.||:.||...::..
Human   157 --PITEN----IRAIYLTLEKL-IQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQD 214

  Fly   190 CIPLRFVEIHMINMRKEGQTIFNFVTKFLPSKLPFKFVVHKKS-EDLYQHLPRDVMTIEYGGTNG 253
            ..|:|...:|::|..:..:.||..:..||..|:..:|.:|... ..|:.:|||.::..|||||.|
Human   215 GFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGTAG 279

  Fly   254 YQAEAVDHWRQKLLDSKDYLAKD 276
            ....|.  |...||.|:|...|:
Human   280 ELDTAT--WNAVLLASEDDFVKE 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10300	NP_651174.2	SEC14	95..251	CDD:238099	43/160 (27%)
TTPAL	NP_001034288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		CRAL_TRIO_N	56..102	CDD:215024	9/45 (20%)
		SEC14	121..277	CDD:238099	43/169 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1031056at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920