DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10300 and SEC14L1

DIOPT Version :9

Sequence 1:	NP_651174.2	Gene:	CG10300 / 42798	FlyBaseID:	FBgn0039107	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	309	Identity:	55/309 - (17%)
Similarity:	109/309 - (35%)	Gaps:	60/309 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLDPKL-AALAKSECNEEQAQRAEIIATIKTWITKSPHLKAPTDEQLILAFLRRCRFSQEETKRR 70
            |.|.|| |...|....:....:...:..::.|:.::...|.|.||. ||.|||...|:.::.:..
Human   234 TPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEH-ILRFLRARDFNIDKAREI 297

  Fly    71 FDNYYSLRSVFPEVLGSRQVDEALLT----QLQRGIHVIPMRPVSPEGPRVIISQFRNIDPK--- 128
            .....:.|.       ..|||..|.|    |:.:..:.........:|..:.:.:...:|.|
Human   298 MCQSLTWRK-------QHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLV 355

  Fly   129 KSNPREA-FKLIFIMLELLALECD------NAAISGLIWVVDARDVTMEQMMQYDPFLLKKAFAL 186
            ::...|| .:.:..:.|.....|:      ...||....:||...:.|..:.:.....|.:...:
Human   356 RALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEV 420

  Fly   187 VDQCIPLRFVEIHMINMRKEGQTIFNFVTKFLPSKLPFKFVVHKKSEDLYQHLPRDVMTIEYGGT 251
            |:...|.....:.::...:....::..|:.|:......||::                   |.|
Human   421 VEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLI-------------------YAG- 465

  Fly   252 NGYQAEA--VDHWRQKLLDSKDYLAKDAQ-------------YGTNEKL 285
            |.||...  :|:..::::  .|:|:.:..             |.|.|:|
Human   466 NDYQGPGGLLDYIDKEII--PDFLSGECMCEVPEGGLVPKSLYRTAEEL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10300	NP_651174.2	SEC14	95..251	CDD:238099	22/169 (13%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	11/45 (24%)
		CRAL_TRIO	326..490	CDD:366224	27/185 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810