DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10300 and CLVS2

DIOPT Version :9

Sequence 1:	NP_651174.2	Gene:	CG10300 / 42798	FlyBaseID:	FBgn0039107	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	280	Identity:	60/280 - (21%)
Similarity:	117/280 - (41%)	Gaps:	13/280 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LDPKLAALAKSECNEEQAQRAEIIATIKTWITKSPHLK-APTDEQLILAFLRRCRFSQEETKRRF 71
            |.|:....|:.|.||......:.|..::..:...|.:. ..||:..||.|||..:|...|..|..
Human     8 LSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLL 72

  Fly    72 DNYYSLRSVFPEVLGS-RQVDEALLTQLQRGIHVIP--MRPVSPEGPRVIISQFRNIDPKKSNPR 133
            ..|:..|....::..| :..|..:...|:.|   .|  :..:...|.::::....|.|..:....
Human    73 AQYFEYRQQNLDMFKSFKATDPGIKQALKDG---FPGGLANLDHYGRKILVLFAANWDQSRYTLV 134

  Fly   134 EAFKLIFIMLELLALECDNAAISGLIWVVDARDVTMEQMMQYDPFLLKKAFALVDQCIPLRFVEI 198
            :..:.|.:.||.: :|.....::|.:.::|..:.|.:|..:..|.:|:.|...:....|.||..|
Human   135 DILRAILLSLEAM-IEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGI 198

  Fly   199 HMINMRKEGQTIFNFVTKFLPSKLPFKFVVHKKS-EDLYQHLPRDVMTIEYGGTNGYQAEAVDHW 262
            |.:|.......::..:..||..|...:..:|..: ..|:|.:..:::..|:||.  .....:..|
Human   199 HFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGM--LPPYDMGTW 261

  Fly   263 RQKLLDSKDYLAKDAQYGTN 282
            .:.|||.:  ...|::|..:
Human   262 ARTLLDHE--YDDDSEYNVD 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10300	NP_651174.2	SEC14	95..251	CDD:238099	31/158 (20%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	12/45 (27%)
		SEC14	106..251	CDD:238099	27/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750