DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10301 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_651173.2	Gene:	CG10301 / 42797	FlyBaseID:	FBgn0039106	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	336	Identity:	65/336 - (19%)
Similarity:	120/336 - (35%)	Gaps:	96/336 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RRPLSPTLAKLAEQEVNETPDRIQQD----------------IIILRVWIRQQPHLRARTDVDFL 50
            |..|.|.|     :.|:...|::..|                :|.||.|: |:.|.......:.:
Human   209 RSTLGPAL-----EAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWL-QETHKGKIPKDEHI 267

  Fly    51 IAFLRRCRYSLEETKRRIDRYFT----HYNLFPEIMNNRCVTQRLLDINRMGVCLYPDMPKGDSR 111
            :.|||...:.|::.:..:.:..:    |.   .:::........||:....|...|.|:   |.|
Human   268 LRFLRAHDFHLDKAREMLRQSLSWRKQHQ---VDLLLQTWQPPALLEEFYAGGWHYQDI---DGR 326

  Fly   112 SAMFIARFGHFDPNLYMLREIYHFSSMAMEVIALENDYASLAGICE---------------IIDL 161
             .::|.|.|..|..  .|.:.....::...|:::..:....   ||               ::||
Human   327 -PLYILRLGQMDTK--GLMKAVGEEALLRHVLSVNEEGQKR---CEGSTRQLGRPISSWTCLLDL 385

  Fly   162 EGVNSDKMRRFDRVLFRKWWNWLYNCSPLKVKEMYIINMPKDIQGTVMF---------LYNVLSM 217
            ||:|.       |.|:|.....|     |::.|:...|.|:.: |.::.         |:.::|.
Human   386 EGLNM-------RHLWRPGVKAL-----LRMIEVVEDNYPETL-GRLLIVRAPRVFPVLWTLISP 437

  Fly   218 QVNYPIR----VLKNSE-----ELIEHIGKESLPEEYGGTNGHLGECVAYMEDLLNSYRGYFEQD 273
            .:|...|    :...|.     .|::::.:|.:|:..||            |.:.|...|.....
Human   438 FINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGG------------ESVCNVPEGGLVPK 490

  Fly   274 CNYGTIEELRH 284
            ..|.|.||..|
Human   491 SLYMTEEEQEH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10301	NP_651173.2	CRAL_TRIO_N	25..71	CDD:215024	11/61 (18%)
CG10301	NP_651173.2	CRAL_TRIO	114..248	CDD:279044	31/166 (19%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		2/4 (50%)
		CRAL_TRIO_N	243..288	CDD:215024	10/45 (22%)
		SEC14	306..479	CDD:214706	40/206 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810