DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10301 and SEC14L1

DIOPT Version :9

Sequence 1:	NP_651173.2	Gene:	CG10301 / 42797	FlyBaseID:	FBgn0039106	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	346	Identity:	66/346 - (19%)
Similarity:	125/346 - (36%)	Gaps:	116/346 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPTLAKLAEQEVNETP-DRIQQD----------------IIILRVWIRQQPHLRARTDVDFLIAF 53
            ||:    |.:.|..|| |::..|                :|.||.|: |:.|.......:.::.|
Human   224 SPS----APEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWL-QETHKGKIPKDEHILRF 283

  Fly    54 LRRCRYSLEETKRRIDRYFTHYNLFPEIMNNRCVTQRLLDINRMGVCLYP-----DMPKG----- 108
            ||...:::::.:              |||......::...::.:.....|     |...|
Human   284 LRARDFNIDKAR--------------EIMCQSLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHH 334

  Fly   109 --DSRSAMFIARFGHFDPNLYMLREIYHFSSMAMEVIALENDYASLAGI--CE------------ 157
              |.| .:::.|.|..|.. .::|.:.. .::...|:::..:     |:  ||
Human   335 DKDGR-PLYVLRLGQMDTK-GLVRALGE-EALLRYVLSINEE-----GLRRCEENTKVFGRPISS 391

  Fly   158 ---IIDLEGVNSDKMRRFDRVLFRKWWNWLYNCSPLKVKEMYIINMPKDIQGTVMFL-----YNV 214
               ::||||:|.       |.|:|.....|     |::.|:...|.|:.: |.::.|     :.|
Human   392 WTCLVDLEGLNM-------RHLWRPGVKAL-----LRIIEVVEANYPETL-GRLLILRAPRVFPV 443

  Fly   215 LSMQVN-------------YPIRVLKNSEELIEHIGKESLPEEYGGTNGHLGECVAYMEDLLNSY 266
            |...|:             |.....:....|:::|.||.:|:...      |||:..:.:
Human   444 LWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLS------GECMCEVPE----- 497

  Fly   267 RGYFEQDCNYGTIEELRHGEI 287
             |.......|.|.|||.:.::
Human   498 -GGLVPKSLYRTAEELENEDL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10301	NP_651173.2	CRAL_TRIO_N	25..71	CDD:215024	10/61 (16%)
CG10301	NP_651173.2	CRAL_TRIO	114..248	CDD:279044	32/168 (19%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	12/59 (20%)
		CRAL_TRIO	326..490	CDD:366224	35/190 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810