DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10301 and Ttpa

DIOPT Version :9

Sequence 1:	NP_651173.2	Gene:	CG10301 / 42797	FlyBaseID:	FBgn0039106	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_037180.1	Gene:	Ttpa / 25571	RGDID:	3915	Length:	278	Species:	Rattus norvegicus

Alignment Length:	285	Identity:	70/285 - (24%)
Similarity:	124/285 - (43%)	Gaps:	31/285 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RPLSPTLAKLAEQEVNETPDR---IQQDIIILRVWIRQQ--PHL-RARTDVDFLIAFLRRCRYSL 61
            || .|.:.|    ::||.||.   :|..:..||...:::  |.. :..||. ||:.|||...:.|
  Rat     5 RP-GPVVGK----QLNEQPDHSPLVQPGLAELRRRAQEEGVPETPQPLTDA-FLLRFLRARDFDL 63

  Fly    62 EETKRRIDRYFTHYNLFPEI---MNNRCVTQRLLDINRMGVCLYPDMPKGDSRSAMFIARFGHFD 123
            :...|.:..|:......||:   ::.|.:. .||.....||....| |.|   |.:.|.|..::|
  Rat    64 DLAWRLMKNYYKWRAECPELSADLHPRSIL-GLLKAGYHGVLRSRD-PTG---SRVLIYRISYWD 123

  Fly   124 PNLYMLREIYHFSSMAMEVIALENDYASLAGICEIIDLEGVNSDKMRRFDRVLFRKWWNWLYNCS 188
            |.::...:::..|.:..|:|..|.: ....|:..|.||||.......:....:.:|....:.:..
  Rat   124 PKVFTAYDVFRVSLITSELIVQEVE-TQRNGVKAIFDLEGWQISHAFQITPSVAKKIAAVVTDSF 187

  Fly   189 PLKVKEMYIINMPKDIQGTVMFLYNVLSMQVNYPIRVLKNS--EELIEHIGKESLPEEYGGTNGH 251
            ||||:.:::||.|.........:...|:.::...|.:..|:  ..|::|. .:.||.||||..
  Rat   188 PLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKGRIHLHGNNYKSSLLQHF-PDILPLEYGGNE-- 249

  Fly   252 LGECVAYMEDLLNSYRGYFEQDCNY 276
                 :.|||:...:..:..:..:|
  Rat   250 -----SSMEDICQEWTNFIMKSEDY 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10301	NP_651173.2	CRAL_TRIO_N	25..71	CDD:215024	13/48 (27%)
CG10301	NP_651173.2	CRAL_TRIO	114..248	CDD:279044	32/135 (24%)
Ttpa	NP_037180.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		8/21 (38%)
		CRAL_TRIO_N	25..73	CDD:215024	13/48 (27%)
		CRAL_TRIO	99..248	CDD:395525	38/154 (25%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		1/1 (100%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920