DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10301 and CLVS1

DIOPT Version :9

Sequence 1:	NP_651173.2	Gene:	CG10301 / 42797	FlyBaseID:	FBgn0039106	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	103/292 - (35%)	Gaps:	95/292 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSPTLAKLAEQEVNETPDRIQQDIIILRVWIRQQPHLR-ARTDVDFLIAFLRRCRYSLEETKRRI 68
            |||...:.|..|:||.||.:.|||..:|..|..:|.:. .|||..|::.|||..::...:..|.:
Human    30 LSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLL 94

  Fly    69 DRYFTHYNL----------------------FPEIMNNRCVTQRLLDINRMGVCLYPDMPKGDSR 111
            .:||.:..|                      ||.::.||                       |..
Human    95 AQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENR-----------------------DHY 136

  Fly   112 SAMFIARF-GHFDPNLYMLREIYHFSSMAMEVIALENDYASLAGICEIID--------------- 160
            ....:..| .::|.:.....:|.....:::||: :|:....:.|...|||
Human   137 GRKILLLFAANWDQSRNSFTDILRAILLSLEVL-IEDPELQINGFILIIDWSNFSFKQASKLTPS 200

  Fly   161 -----LEGVNSDKMRRFDRVLF--RKWWNWLYNCSPLKVKEMYIINMP--KDIQGTVMFLYNVLS 216
                 :||:......||..|.|  :.|:          :..:|.:..|  ||.....:||:.
Human   201 ILKLAIEGLQDSFPARFGGVHFVNQPWY----------IHALYTLIKPFLKDKTRKRIFLHG--- 252

  Fly   217 MQVNYPIRVLKNSEELIEHIGKESLPEEYGGT 248
                      .|...|.:.|..|.||.|:|||
Human   253 ----------NNLNSLHQLIHPEFLPSEFGGT 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10301	NP_651173.2	CRAL_TRIO_N	25..71	CDD:215024	14/46 (30%)
CG10301	NP_651173.2	CRAL_TRIO	114..248	CDD:279044	31/158 (20%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	14/45 (31%)
		CRAL_TRIO	125..274	CDD:306996	36/195 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750