Protein Alignment Gba1a and Gba

DIOPT Version :9

• Sequence 1: NP_651172.1
• Gene: Gba1a / 42796
• FlyBaseID: FBgn0051148
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_001121111.1
• Gene: Gba / 684536
• RGDID: 1589149
• Length: 515
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 178/559 - (31%)
• Similarity: 282/559 - (50%)
• Gaps: 63/559 - (11%)

  Fly    13 LGVLLVSAIGGQSESIPCKLIDAEHG---KVCVCTADYCDYLENPVLTDENEWFLISSSKQGLRF 74
            :|:.|..||.....:.||  |....|   .||||.|.|||.|:...|.....:....|::.|.|.
  Rat     6 IGLFLFQAISWAYGAQPC--IPKSFGYSSVVCVCNATYCDSLDPLTLPALGTFSRYESTRSGRRM 68

  Fly    75 STTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLRLDRSKT 139
            ..::.        ::|         ||.|....||        ||:..|.
  Rat    69 ELSTG--------SIQ---------ANRTGTGLLL--------TLQPEEK--------------- 93

  Fly   140 HQKMVGFGGSYTG--AVEYLVENFKHSELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEPWSYA 202
            .||:.||||:.|.  |:..|..:....:|   |.||:::.:|:.:|::||.:..|||.:..::||
  Rat    94 FQKVKGFGGAMTDATALNILALSPPAQKL---LLKSYFSSEGIEYNIIRVPMASCDFSIRIYTYA 155

  Fly   203 EEEGDTELSDMDELNAHDVTRVAQIKRLIEVSGVKNLLVKGAAWSSPPWMKTNNRWTGFGRLK-- 265
            :...|.:||:..........::..|.|.:::| .:.:.:..:.|:||.|:|||....|.|.||
  Rat   156 DTPNDFQLSNFSLPEEDTKLKIPLIHRALKMS-PRPISLFASPWTSPTWLKTNGAVNGKGSLKGH 219

  Fly   266 --RAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVKFMSLGWTPQTQAIWLNDY 328
              ..|::.||:|.:::|.....:.|..||::..|||..|:...|  .|..||:|.:.|..:::..
  Rat   220 PGDIYHEAWANYFVKFLDAYATHNIKFWAVTAENEPSAGLFTGY--PFQCLGFTAEHQRDFISHD 282

  Fly   329 LGPTIRNSEFKDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGLSLHWYWDEIF-GNSFIEQT 392
            |||.:.||. .|:.|...||||...|.|.::: .:.|.:..|:.|:::|||.|.:. ..:.:.:|
  Rat   283 LGPALANSS-HDVKLLILDDQRLLLPRWAQVV-LSDPEAAKYVHGIAVHWYMDFLAPAKATLGET 345

  Fly   393 KEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKLGFHGWIDWNICLDEIGGP 457
            ....|:.:|..||:|:|.|.|:.:. .||||:|..:|:...:.|:.....||.|||:.|:..|||
  Rat   346 HRLFPNMMLFASEACVGSKFWEQSV-RLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGP 409

  Fly   458 NYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVRIDAVPS-NVNLDSVAFLRPDNK 521
            |:|.|.||:|:||:... :.||||||||.:|||||::||||.|:..|.| ..:|::||.:|||..
  Rat   410 NWVRNFVDSPIIVDIPK-DTFYKQPMFYHLGHFSKFIPEGSQRVGLVASEKTDLETVALIRPDGS 473

  Fly   522 ITAVLFNSGRADLDITLVDSIRGQFVVNVPAKSIHTLLY 560
            ...|:.|....|:.:|:.|...|......|..||||.|:
  Rat   474 AVVVVLNRSSKDVPLTISDPALGFMETISPGYSIHTYLW 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gba1a	NP_651172.1	Glyco_hydro_30	29..558	CDD:304972	172/539 (32%)
Gba	NP_001121111.1	Glyco_hydro_30	20..512	CDD:304972	173/543 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352289
Domainoid	1	1.000	232	1.000	Domainoid score	I2327
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2770
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm44865
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	O	PTHR11069
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810