DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gba1a and GBA

DIOPT Version :9

Sequence 1:	NP_651172.1	Gene:	Gba1a / 42796	FlyBaseID:	FBgn0051148	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_000148.2	Gene:	GBA / 2629	HGNCID:	4177	Length:	536	Species:	Homo sapiens

Alignment Length:	563	Identity:	184/563 - (32%)
Similarity:	285/563 - (50%)	Gaps:	72/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GVLLVSAIGGQSESIPCKLIDAEHG---KVCVCTADYCDYLENPVLTDENEWFLISSSKQGLRFS 75
            |:||:.|:...|.:.||  |....|   .||||.|.|||..:.|.......:....|::.|.|..
Human    27 GLLLLQAVSWASGARPC--IPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRME 89

  Fly    76 TTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLRLDRSKTH 140
            .:               :.|.|  ||.|....||        ||:..:.               .
Human    90 LS---------------MGPIQ--ANHTGTGLLL--------TLQPEQK---------------F 114

  Fly   141 QKMVGFGGSYTGAVEYLV-------ENFKHSELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEP 198
            ||:.||||:.|.|....:       :|.        |.||:::|:|:|:|::||.:..|||.:..
Human   115 QKVKGFGGAMTDAAALNILALSPPAQNL--------LLKSYFSEEGIGYNIIRVPMASCDFSIRT 171

  Fly   199 WSYAEEEGDTELSDMDELNAHDVTRVAQIKRLIEVSGVKNLLVKGAAWSSPPWMKTNNRWTGFGR 263
            ::||:...|.:|.:..........::..|.|.:::: .:.:.:..:.|:||.|:|||....|.|.
Human   172 YTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLA-QRPVSLLASPWTSPTWLKTNGAVNGKGS 235

  Fly   264 LK----RAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVKFMSLGWTPQTQAIW 324
            ||    ..|:||||.|.:::|....::.:..||::..|||..|::..|  .|..||:||:.|..:
Human   236 LKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGY--PFQCLGFTPEHQRDF 298

  Fly   325 LNDYLGPTIRNSEFKDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGLSLHWYWDEIF-GNSF 388
            :...||||:.||...::.|...||||...|||.|:: .|.|.:..|:.|:::|||.|.:. ..:.
Human   299 IARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVV-LTDPEAAKYVHGIAVHWYLDFLAPAKAT 362

  Fly   389 IEQTKEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKLGFHGWIDWNICLDE 453
            :.:|....|:.:|..||:|:|.|.|:.:. .||||:|..:|:...:.|:.....||.|||:.|:.
Human   363 LGETHRLFPNTMLFASEACVGSKFWEQSV-RLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNP 426

  Fly   454 IGGPNYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVRIDAVPSNVN-LDSVAFLR 517
            .||||:|.|.||:|:||:.|. :.||||||||.:|||||::||||.|:..|.|..| ||:||.:.
Human   427 EGGPNWVRNFVDSPIIVDITK-DTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMH 490

  Fly   518 PDNKITAVLFNSGRADLDITLVDSIRGQFVVNVPAKSIHTLLY 560
            ||.....|:.|....|:.:|:.|...|......|..||||.|:
Human   491 PDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLW 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gba1a	NP_651172.1	Glyco_hydro_30	29..558	CDD:304972	177/544 (33%)
GBA	NP_000148.2	Glyco_hydro_30	117..466	CDD:307945	126/362 (35%)
GBA	NP_000148.2	Glyco_hydro_30C	469..531	CDD:319207	22/61 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158305
Domainoid	1	1.000	240	1.000	Domainoid score	I2262
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2758
Isobase	1	0.950	-	0	Normalized mean entropy	S4252
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm40726
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	O	PTHR11069
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720