Protein Alignment Gba1a and gba-2

DIOPT Version :9

• Sequence 1: NP_651172.1
• Gene: Gba1a / 42796
• FlyBaseID: FBgn0051148
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_494208.2
• Gene: gba-2 / 183155
• WormBaseID: WBGene00016340
• Length: 516
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 158/580 - (27%)
• Similarity: 255/580 - (43%)
• Gaps: 108/580 - (18%)

  Fly     9 GMLVLGVLLVSAIGGQSESIPCKLIDAEHGKVCVCTADYCDYLEN-PVLTDENEWFLISSSKQGL 72
            |:..|..|.|:...      .|.....:.|.||||...|||.:.: .:|:.:...|  ::||.|.
 Worm    11 GLFALASLQVALAN------DCAQKTFKTGIVCVCNITYCDEIPDINLLSGQAATF--TTSKSGA 67

  Fly    73 RFSTTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLRLDRS 137
            |..              :|.|..|..           |.:....||::|               |
 Worm    68 RLH--------------RDVVYATNS-----------DPLTSMHFTIDS---------------S 92

  Fly   138 KTHQKMVGFGGSYTGAVEYLVENFKH--SELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEPWS 200
            ||:|.:.|||.:::.|..   .|.|.  .::||.:.:.::::.||.....||.|...||....::
 Worm    93 KTYQTIQGFGSTFSDASG---ANLKSLPDQMADTILRQYFSDSGLNLQFGRVPIASNDFSSRVYT 154

  Fly   201 YAEEEGDTELS----------------DMDELNAHDVTRVAQIKRLIEVSGVKNLLVKGAAWSSP 249
            |.:...|..::                .|.:...||:...|                  ..||:|
 Worm   155 YDDNLEDYNMAHFSLQREDYQWKIPYMQMAQKYNHDLKFFA------------------VPWSAP 201

  Fly   250 PWMKTNNRWTGFGRL----KRAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVK 310
            .|:||.|...|:|.|    :..|::::..|.|.:|...:.|||..|.:||.|||.:|....  .|
 Worm   202 GWLKTTNSTKGYGILLGTNQDTYHKSYVTYILHFLEEYQKNGILFWGLSTQNEPTSGSDKK--TK 264

  Fly   311 FMSLGWTPQTQAIWLNDYLGPTIRNSEF-KDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGL 374
            ..|:|:|.:.|..::...:||.:::|.. |::.:...||.|.:.|.|...:...: ::..|:.|:
 Worm   265 MQSMGFTAEFQRDFIKLDIGPALKSSNAGKNVKILILDDNRGNLPKWADTVLNDK-DAASYVSGI 328

  Fly   375 SLHWYWDEIFGNSFIEQTKEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKL 439
            ::|.|.|: ..:..:.||....||..:..:|:..|.|.....   .||::|||.|..|.|.:...
 Worm   329 AVHSYQDD-ESDKHLTQTHNNHPDVFIFGTEASEGSKSKDVD---YGSFDRAEDYVSDILDDFNN 389

  Fly   440 GFHGWIDWNICLDEIGGPNYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVRID-- 502
            ...||.:.|:.||..|||::|....|||||. .....:||||||||||.|||.::..|:||||
 Worm   390 WVTGWTERNLVLDAQGGPSWVSGFADAPVIA-FPALAQFYKQPMFYAIAHFSHFLKPGAVRIDHS 453

  Fly   503 -AVPSNVNLDSVAFLRPDNKITAVLFNSG-RADLDITLVDSIRG--QFVVNVPAKSIHTL 558
             .:| |..::..|||.||.....||.|.. .|...:::.|:::.  .:.|::..|:|.||
 Worm   454 LNMP-NPEIERSAFLNPDGSKVVVLHNKNPLAPYSLSIKDTMKSTDHYQVHLSPKTIVTL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gba1a	NP_651172.1	Glyco_hydro_30	29..558	CDD:304972	152/558 (27%)
gba-2	NP_494208.2	Glyco_hydro_30	23..515	CDD:110998	154/568 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166005
Domainoid	1	1.000	225	1.000	Domainoid score	I1442
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1794
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		mtm4803
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.770