Protein Alignment Gba1a and gba-4

DIOPT Version :9

• Sequence 1: NP_651172.1
• Gene: Gba1a / 42796
• FlyBaseID: FBgn0051148
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_500785.1
• Gene: gba-4 / 177314
• WormBaseID: WBGene00021160
• Length: 519
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 167/568 - (29%)
• Similarity: 280/568 - (49%)
• Gaps: 61/568 - (10%)

  Fly     4 MFASRGMLVLGVLLVSAIGGQSESIPCKLIDAEHGKVCVCTADYCDYLENPVLTDENEWFLISSS 68
            |..:..:.:|..|........::|:||..:..|:|.||.|.|.|||.:|........:..:.::|
 Worm     1 MILNISVSLLIFLAFYGFSSDAKSLPCSEVKKEYGIVCRCNATYCDTIEPLGTVTSGKAVVYTTS 65

  Fly    69 KQGLRFSTTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLR 133
            :.|.|.:.:..|.........:.||..||
 Worm    66 RNGKRMNRSELKHTTSSTAKTKVYVNTTQ------------------------------------ 94

  Fly   134 LDRSKTHQKMVGFGGSYTGAVEYLVENFKHSELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEP 198
                 :.|.::|||.::|.|....::....: :.|.:.:.::::||||:...||.:...||....
 Worm    95 -----SFQPVMGFGAAFTDAAGINMKMLPQT-MQDQIIQQYFSDDGLGYVFGRVPMASTDFSTHE 153

  Fly   199 WSYAEEEGDTELSDMDELNAHDVT-RVAQIKRLIEVSGVKNLLVKGAAWSSPPWMKTNNRWTGFG 262
            :||.:.:.|.:|.:.: |...|:. ::..||:.:..||.| |.:....||||.||||:.|..|.|
 Worm   154 YSYDDVKFDFDLKNFN-LTVEDLQYKIPFIKKAMTASGGK-LKLFATPWSSPGWMKTSGRMVGAG 216

  Fly   263 RL----KRAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVKFMSLGWTPQTQAI 323
            .|    ...||||||.|.:::.......||..|:::..|||..||..::  |:.:|.:....:..
 Worm   217 ELLGDQNGKYYQTWAQYFVKFFEAYHAQGIDFWSLTPQNEPTTGIDPLW--KWQTLFFDASMERN 279

  Fly   324 WLNDYLGPTIRNSEF-KDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGLSLHWYWDEIFGNS 387
            ::...|||.:.:|.. |::.:..|||||.:.|||..:: .|.|.:..|:.|:::|||.|.|...:
 Worm   280 FIKKLLGPALASSPVTKNLKIMINDDQRINLPHWPNVI-LTDPTAAQYVHGIAIHWYEDFIDPAT 343

  Fly   388 FIEQTKEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKLGFHGWIDWNICLD 452
            .:.:|.|..||..|:.:|:|.|..|  |..|.||||.|||:||.|.:.::.....||:|||..||
 Worm   344 VLTETHEKFPDYFLLATEACAGYFP--ADGPKLGSWSRAEQYANDLIKDMGNWVGGWVDWNYILD 406

  Fly   453 EIGGPNYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVR--IDAVPSNVNLDSVAF 515
            ..||||...|.||:.:|||.|. :|:||||:::.:..|||:|..|::|  |:.:..:|:::.::|
 Worm   407 LQGGPNLAKNFVDSTIIVNATA-QEYYKQPIWHVMAQFSKFVKPGAIRVGINIIEKSVDVEGLSF 470

  Fly   516 LRPDNKITAVLFNSGRA---DLDITLVDSIRGQFVVNVPAKSIHTLLY 560
            |..|...|.||.|....   |:.|:.|.:....:.:.:...|:.|::|
 Worm   471 LNQDGTKTVVLLNKNEVLSFDVAISDVSAPNVIYDLTIQPNSLITIVY 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gba1a	NP_651172.1	Glyco_hydro_30	29..558	CDD:304972	161/539 (30%)
gba-4	NP_500785.1	Glyco_hydro_30	26..516	CDD:304972	161/539 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166004
Domainoid	1	1.000	225	1.000	Domainoid score	I1442
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1794
Isobase	1	0.950	-	0	Normalized mean entropy	S4252
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		mtm4803
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	O	PTHR11069
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3226
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750