DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gba1a and Gba

DIOPT Version :9

Sequence 1:	NP_651172.1	Gene:	Gba1a / 42796	FlyBaseID:	FBgn0051148	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001070879.1	Gene:	Gba / 14466	MGIID:	95665	Length:	515	Species:	Mus musculus

Alignment Length:	560	Identity:	177/560 - (31%)
Similarity:	281/560 - (50%)	Gaps:	63/560 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLGVLLVSAIGGQSESIPCKLIDAEHG---KVCVCTADYCDYLENPVLTDENEWFLISSSKQGLR 73
            ::|..|..|:.....:.||  |....|   .||||.|.|||.|:...|.....:....|:::|.|
Mouse     5 LIGFFLFQAVSWAYGAQPC--IPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRR 67

  Fly    74 FSTTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLRLDRSK 138
            ...:               |...|.....|.|                         .|.|...|
Mouse    68 MELS---------------VGAIQANRTGTGL-------------------------LLTLQPEK 92

  Fly   139 THQKMVGFGGSYTG--AVEYLVENFKHSELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEPWSY 201
            ..||:.||||:.|.  |:..|..:....:|   |.:|:::.:|:.:|::||.:..|||.:..::|
Mouse    93 KFQKVKGFGGAMTDATALNILALSPPTQKL---LLRSYFSTNGIEYNIIRVPMASCDFSIRVYTY 154

  Fly   202 AEEEGDTELSDMDELNAHDVTRVAQIKRLIEVSGVKNLLVKGAAWSSPPWMKTNNRWTGFGRLK- 265
            |:...|.:||:..........::..|.:.:::|. :.:.:..:.|:||.|:|||.|..|.|.||
Mouse   155 ADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSS-RPISLFASPWTSPTWLKTNGRVNGKGSLKG 218

  Fly   266 ---RAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVKFMSLGWTPQTQAIWLND 327
               ..::||||:|.:::|......|:..||::..|||..|:...|  .|..||:||:.|..:::.
Mouse   219 QPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGY--PFQCLGFTPEHQRDFISR 281

  Fly   328 YLGPTIRNSEFKDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGLSLHWYWDEIF-GNSFIEQ 391
            .|||.:.||. .|:.|...||||...|.|.::: .:.|.:..|:.|:::|||.|.:. ..:.:.:
Mouse   282 DLGPALANSS-HDVKLLMLDDQRLLLPRWAEVV-LSDPEAAKYVHGIAVHWYMDFLAPAKATLGE 344

  Fly   392 TKEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKLGFHGWIDWNICLDEIGG 456
            |....|:.:|..||:|:|.|.|:.:. .||||:|..:|:...:.|:.....||.|||:.|:..||
Mouse   345 THRLFPNTMLFASEACVGSKFWEQSV-RLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGG 408

  Fly   457 PNYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVRIDAVPS-NVNLDSVAFLRPDN 520
            ||:|.|.||:|:||:... :.||||||||.:|||||::||||.|:..|.| :.:|::||.||||.
Mouse   409 PNWVRNFVDSPIIVDIPK-DAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDG 472

  Fly   521 KITAVLFNSGRADLDITLVDSIRGQFVVNVPAKSIHTLLY 560
            ....|:.|....|:.:|:.|...|......|..||||.|:
Mouse   473 SAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLW 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gba1a	NP_651172.1	Glyco_hydro_30	29..558	CDD:304972	172/539 (32%)
Gba	NP_001070879.1	Glyco_hydro_30	20..512	CDD:304972	173/543 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848703
Domainoid	1	1.000	235	1.000	Domainoid score	I2352
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2813
Isobase	1	0.950	-	0	Normalized mean entropy	S4252
OMA	1	1.010	-	-		QHG62715
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm42800
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	O	PTHR11069
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3226
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740