DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VAChT and slc18a3

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001072859.1	Gene:	slc18a3 / 780320	XenbaseID:	XB-GENE-965085	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	257/500 - (51%)
Similarity:	338/500 - (67%)	Gaps:	23/500 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDDGPTPPPLRDNITGKIIPVHH 88
            |:||.:|||:||:||.:||.||||||||||||||||::.:.:..:.............|...:..
Frog    32 IKEPHHQRRIILIIVCVALFLDNMLYMVIVPIIPDYIQNLRADREHAKSINSSSQYRNKSFAIRP 96

  Fly    89 DH--HGQDSATGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVL 151
            .:  ..:|...|:|||||||:||::||.||..||::|||:|::|||.::||||.:||...:|:.|
Frog    97 QYPAENEDMQIGVLFASKAILQLLINPLSGTFIDRVGYDIPLLIGLVVLFFSTVIFAFAENYATL 161

  Fly   152 FFARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEV 216
            |.||||||.|||||||:|:|||||.:|||.|||:||||||||||||.||||||||.||||.||.:
Frog   162 FVARSLQGLGSAFADTSGIAMIADTYTEEAERSKALGIALAFISFGSLVAPPFGGILYQFVGKRM 226

  Fly   217 PFLILALVCLLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAF 281
            |||:||.:.|:||::||||:||.....:.:..:.   .||.||::||||||.|||||..|:.|||
Frog   227 PFLVLASIALIDGVLLLLVIKPFTNRTRANMPIG---TPIHRLMIDPYIAVVAGALTTCNIPLAF 288

  Fly   282 LEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCF 346
            |||||:.||:..|....|::|:.||||||||||||.||||:|..||.:||...|.|:.:.|.|..
Frog   289 LEPTIANWMKTTMDASEWQMGLTWLPAFFPHVLGVYITVKLAANYPHYQWFYGAIGMVIIGASSC 353

  Fly   347 IIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPI 411
            .:|.|..:..|::|:|.|||||||:||||||||..|||||:||||||:||||||||.:|||:||:
Frog   354 TVPACKNFWELIVPLCGICFGIALVDTALLPTLALLVDVRHVSVYGSVYAIADISYCVAYALGPV 418

  Fly   412 IAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMHDQ 476
            :|..:|...|||.||..:..:|:.|.|.|..|||:...||..:|.|||:::.|...|.|..|.::
Frog   419 VASQIVHTTGFTQLNLGMGLANVLYAPALLFLRNVCQMKPSHSERNILLEEGPKGLYDTIKMEER 483

  Fly   477 KPVEGGVKNHL-------------EYGQQYQQEQETNLDDQQYEY 508
            |     .|:|.             .|.:.::....:..|...|||
Frog   484 K-----AKSHKRNPNDGMNDSIMDNYHEPHKGIYGSEEDSSDYEY 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	194/323 (60%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	95/139 (68%)
slc18a3	NP_001072859.1	MFS_SLC18A3_VAChT	43..451	CDD:340941	229/410 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11022
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1297
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	1	1.000	-	-		oto105127
Panther	1	1.100	-	-	LDO	PTHR23506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2004
SonicParanoid	1	1.000	-	-		X4405
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110