DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VAChT and SLC18A3

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_003046.2	Gene:	SLC18A3 / 6572	HGNCID:	10936	Length:	532	Species:	Homo sapiens

Alignment Length:	493	Identity:	259/493 - (52%)
Similarity:	335/493 - (67%)	Gaps:	28/493 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDDGPT-------- 71
            ::.:.|...:|||..||||:||||.:|||||||||||||||:|||:..:....:|||
Human    16 KLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEP 80

  Fly    72 --PPPLRDNIT----------------GKIIPVHHDHHGQDSATGILFASKAIVQLMVNPFSGGL 118
              |.|...|.:                |..:...:....:|...|:|||||||:||:|||.||..
Human    81 TLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPF 145

  Fly   119 IDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAGSAFADTAGLAMIADRFTEENER 183
            ||::.||:|::|||.:||.||.:||....|:.||.||||||.|||||||:|:|||||::.||.||
Human   146 IDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPER 210

  Fly   184 SQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVCLLDGLMLLLVMKPVKEAMKQSKD 248
            |:|||:||||||||.||||||||.||:||||.||||:||.|.|.|.|:||.|.||...|.:...:
Human   211 SRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAN 275

  Fly   249 VQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHV 313
            :.... ||.||::||||||.|||||..|:.||||||||:.||:..|....|::||.|||||.|||
Human   276 LPVGT-PIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHV 339

  Fly   314 LGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPT 378
            |||.:||::|.:||..|||..|.|||:.|.|..|:|.|..:..|::.:|.:||||||:|||||||
Human   340 LGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPT 404

  Fly   379 LGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKL 443
            |.:|||||:||||||:|||||||||:|||:|||:||.:|.::||..|:..:..:||.|.|||..|
Human   405 LAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLL 469

  Fly   444 RNIYDFKPFENEANILMQDPPNKEYQTYVMHDQKPVEG 481
            ||:.......:|.::|:.:||...|.. |...::||.|
Human   470 RNVGLLTRSRSERDVLLDEPPQGLYDA-VRLRERPVSG 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	195/321 (61%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	94/139 (68%)
SLC18A3	NP_003046.2	MFS	124..458	CDD:119392	203/334 (61%)
		MFS_1	124..436	CDD:284993	194/312 (62%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250\|UniProtKB:O35304	471..532		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..523		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147525
Domainoid	1	1.000	336	1.000	Domainoid score	I1126
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11022
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1403
Isobase	1	0.950	-	0	Normalized mean entropy	S4425
OMA	1	1.010	-	-		QHG59108
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	1	1.000	-	-		oto91351
orthoMCL	1	0.900	-	-		OOG6_107939
Panther	1	1.100	-	-	LDO	PTHR23506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2004
SonicParanoid	1	1.000	-	-		X4405
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.740