Protein Alignment VAChT and SLC18A2

DIOPT Version :9

• Sequence 1: NP_477138.1
• Gene: VAChT / 42795
• FlyBaseID: FBgn0270928
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_003045.2
• Gene: SLC18A2 / 6571
• HGNCID: 10935
• Length: 514
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 192/553 - (34%)
• Similarity: 294/553 - (53%)
• Gaps: 100/553 - (18%)

  Fly    11 LEVREVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYL--------------- 60
            :.:.|:..:.|  :||....|:|||.||.:||||||||..|:|||||.||
Human     1 MALSELALVRW--LQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTA 63

  Fly    61 ------------REIGSFDDGPTPPPLRDNITG---KIIPVHH---------------------- 88
                        :.|.|:.|..|      .:||   :.:.:|.
Human    64 RPVHTASISDSFQSIFSYYDNST------MVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDK 122

  Fly    89 DHHGQDSATGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFF 153
            |...::...|:||||||.|||:.|||.|.|.::|||.:|:..|..|||.||.:||..|||:.|..
Human   123 DLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLI 187

  Fly   154 ARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPF 218
            ||||||.||:.:..||:.|:|..:|::.||...:||||..::.|.||.||||..||:|.||..||
Human   188 ARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPF 252

  Fly   219 LILALVCLLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLE 283
            |:||.:.||||.:.|.|::|.:...:..|..     |:..||.||||.:.||::..:|:.:|.||
Human   253 LVLAALVLLDGAIQLFVLQPSRVQPESQKGT-----PLTTLLKDPYILIAAGSICFANMGIAMLE 312

  Fly   284 PTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGV----VITVKMARKYPQHQWLMAAGGLALEGFS 344
            |.:.:||.:.|.:..|::|:.:|||...:::|.    ::..||.|      ||.|..|:.:.|.|
Human   313 PALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR------WLCALLGMIIVGVS 371

  Fly   345 CFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVG 409
            ...|||......|:.|...:.|.|.::|::::|.:|||||:|:||||||:|||||:::.:.||:|
Human   372 ILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIG 436

  Fly   410 PIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMH 474
            |...|.:.:||||..|..:|...::.:.|:...||:                 ||.||.:..::.
Human   437 PSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRS-----------------PPAKEEKMAILM 484

  Fly   475 DQK-PVEGGV--KNHLEYGQQYQ--QEQETNLD 502
            |.. |::..:  :|::   |.|.  :::|:..|
Human   485 DHNCPIKTKMYTQNNI---QSYPIGEDEESESD 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	136/347 (39%)
		2_A_01_02	98..238	CDD:273318	73/139 (53%)
SLC18A2	NP_003045.2	MFS_1	130..437	CDD:311564	135/317 (43%)
		2_A_01_02	132..273	CDD:273318	73/140 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2004
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960