DRSC/TRiP Functional Genomics Resources

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Protein Alignment VAChT and SLC18A1

DIOPT Version :9

Sequence 1:NP_477138.1 Gene:VAChT / 42795 FlyBaseID:FBgn0270928 Length:578 Species:Drosophila melanogaster
Sequence 2:NP_001129163.1 Gene:SLC18A1 / 6570 HGNCID:10934 Length:525 Species:Homo sapiens


Alignment Length:581 Identity:189/581 - (32%)
Similarity:300/581 - (51%) Gaps:119/581 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VREVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLRE--------------- 62
            :|.:.|.....::|....|:|:||:|.:||||||||:.|:|||:|.:|.:               
Human     2 LRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHA 66

  Fly    63 --------------IGSFDDGPT---------------------PPPLRDNITGKIIPVHHDHHG 92
                          |.||.:..|                     |||..:.|:     .|.::..
Human    67 GSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAIS-----AHKNNCL 126

  Fly    93 QDSA--------TGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYS 149
            |.:.        .|:||||||::||:||||.|.|.::|||.:||..|..|||.||.:||...:|:
Human   127 QGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYT 191

  Fly   150 VLFFARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGK 214
            :||.||:|||.||:|:..|||.|:|..:|:::||.:|:|.||..::.|.||..|||..:|:|.||
Human   192 LLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGK 256

  Fly   215 EVPFLILALVCLLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVAL 279
            ..||||||.:.||||.:.|.:::|.|.:.:.:|..     |::.||.||||.|.||::..:|:.:
Human   257 SAPFLILAFLALLDGALQLCILQPSKVSPESAKGT-----PLFMLLKDPYILVAAGSICFANMGV 316

  Fly   280 AFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGV----VITVKMARKYPQHQWLMAAGGLAL 340
            |.||||:.:||...|.:..|::|:.:|||...:::|.    |:..||.|      ||.:..|:.:
Human   317 AILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR------WLCSLIGMLV 375

  Fly   341 EGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIA 405
            .|.|...:|.......|:.|...:...|.::|::::|.:|:|||:|:.|||||:|||||:::.:.
Human   376 VGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMG 440

  Fly   406 YAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQT 470
            :|:||...|.:|:||||..|..:....|:.|.|:...||:                 ||.||.:.
Human   441 FAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS-----------------PPAKEEKL 488

  Fly   471 YVMHDQKPVEGGVKNHLEYGQQYQQEQETNLDDQQYEYQQQQQGYQQGYQQDQGYQPGYQE 531
            .::....|:|                      .:.|..|:..:.:..|...|:  :|.::|
Human   489 AILSQDCPME----------------------TRMYATQKPTKEFPLGEDSDE--EPDHEE 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VAChTNP_477138.1 MFS_1 88..410 CDD:284993 132/333 (40%)
2_A_01_02 98..238 CDD:273318 72/139 (52%)
SLC18A1NP_001129163.1 MFS_1 139..445 CDD:284993 131/316 (41%)
2_A_01_02 140..281 CDD:273318 72/140 (51%)
MFS 302..>479 CDD:119392 62/182 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..525 4/23 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3764
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59108
OrthoDB 1 1.010 - - D406900at33208
OrthoFinder 1 1.000 - - FOG0000700
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2004
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.860

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