Protein Alignment VAChT and SLC18A1

DIOPT Version :10

• Sequence 1: NP_477138.1
• Gene: VAChT / 42795
• FlyBaseID: FBgn0270928
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_003044.1
• Gene: SLC18A1 / 6570
• HGNCID: 10934
• Length: 525
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 189/581 - (32%)
• Similarity: 300/581 - (51%)
• Gaps: 119/581 - (20%)

  Fly    13 VREVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLRE--------------- 62
            :|.:.|.....::|....|:|:||:|.:||||||||:.|:|||:|.:|.:
Human     2 LRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHA 66

  Fly    63 --------------IGSFDDGPT---------------------PPPLRDNITGKIIPVHHDHHG 92
                          |.||.:..|                     |||..:.|:     .|.::..
Human    67 GSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAIS-----AHKNNCL 126

  Fly    93 QDSA--------TGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYS 149
            |.:.        .|:||||||::||:||||.|.|.::|||.:||..|..|||.||.:||...:|:
Human   127 QGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYT 191

  Fly   150 VLFFARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGK 214
            :||.||:|||.||:|:..|||.|:|..:|:::||.:|:|.||..::.|.||..|||..:|:|.||
Human   192 LLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGK 256

  Fly   215 EVPFLILALVCLLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVAL 279
            ..||||||.:.||||.:.|.:::|.|.:.:.:|..     |::.||.||||.|.||::..:|:.:
Human   257 SAPFLILAFLALLDGALQLCILQPSKVSPESAKGT-----PLFMLLKDPYILVAAGSICFANMGV 316

  Fly   280 AFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGV----VITVKMARKYPQHQWLMAAGGLAL 340
            |.||||:.:||...|.:..|::|:.:|||...:::|.    |:..||.|      ||.:..|:.:
Human   317 AILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR------WLCSLIGMLV 375

  Fly   341 EGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIA 405
            .|.|...:|.......|:.|...:...|.::|::::|.:|:|||:|:.|||||:|||||:::.:.
Human   376 VGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMG 440

  Fly   406 YAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQT 470
            :|:||...|.:|:||||..|..:....|:.|.|:...||:                 ||.||.:.
Human   441 FAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS-----------------PPAKEEKL 488

  Fly   471 YVMHDQKPVEGGVKNHLEYGQQYQQEQETNLDDQQYEYQQQQQGYQQGYQQDQGYQPGYQE 531
            .::....|:|                      .:.|..|:..:.:..|...|:  :|.::|
Human   489 AILSQDCPME----------------------TRMYATQKPTKEFPLGEDSDE--EPDHEE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_SLC18A3_VAChT	35..444	CDD:340941	170/470 (36%)
SLC18A1	NP_003044.1	MFS_SLC18A1_2_VAT1_2	131..479	CDD:340942	143/358 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..525		4/23 (17%)