DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VAChT and Slc18a3

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_113851.1	Gene:	Slc18a3 / 60422	RGDID:	62072	Length:	530	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	258/494 - (52%)
Similarity:	337/494 - (68%)	Gaps:	27/494 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDDGPT-------- 71
            ::.:.|...:|||..||||:||||.:|||||||||||||||:|||:..:....:|||
  Rat    16 KLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTLVSEVWEP 80

  Fly    72 --PPPLRDNITG----------------KIIPVHHDHHGQDSATGILFASKAIVQLMVNPFSGGL 118
              |||...|.:.                .|:...:....:|...|:|||||||:||:|||.||..
  Rat    81 TLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPF 145

  Fly   119 IDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAGSAFADTAGLAMIADRFTEENER 183
            ||::.||:|::|||.:||.||.:||....|:.||.||||||.|||||||:|:|||||::.||.||
  Rat   146 IDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPER 210

  Fly   184 SQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVCLLDGLMLLLVMKPVKEAMKQSKD 248
            |:|||:||||||||.||||||||.||:||||.||||:||.|.|.|.|:||.|.||...|.:...:
  Rat   211 SRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAN 275

  Fly   249 VQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHV 313
            :.... ||.||::||||||.|||||..|:.||||||||:.||:..|....|::||||||||.|||
  Rat   276 LPVGT-PIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHV 339

  Fly   314 LGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPT 378
            |||.:||::|.:||..|||..|.|||:.|.|..::|.|..:..|::.:|.:||||||:|||||||
  Rat   340 LGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPT 404

  Fly   379 LGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKL 443
            |.:|||||:||||||:|||||||||:|||:|||:||.:|.::||..|:..:..:||.|.|||..|
  Rat   405 LAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLL 469

  Fly   444 RNIYDFKPFENEANILMQDPPNKEYQTYVMHDQKPVEGG 482
            ||:.......:|.::|:.:||...|....:.:.:..:||
  Rat   470 RNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	195/321 (61%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	94/139 (68%)
Slc18a3	NP_113851.1	MFS_SLC18A3_VAChT	36..459	CDD:340941	234/423 (55%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250\|UniProtKB:O35304	471..530		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..530		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341325
Domainoid	1	1.000	332	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11022
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1303
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	1	1.000	-	-		oto98433
orthoMCL	1	0.900	-	-		OOG6_107939
Panther	1	1.100	-	-	LDO	PTHR23506
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4405
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910