DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VAChT and slc18a1

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	XP_012814578.1	Gene:	slc18a1 / 594935	XenbaseID:	XB-GENE-5738585	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	163/517 - (31%)
Similarity:	251/517 - (48%)	Gaps:	90/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIP------DYLREIGSFDDGPTPPP----- 74
            ||       .|..||::|::.:.:|.:|:.:|.||.|      :|.|...:|.:.....|
Frog    15 WE-------SRAPILLVVAVVMFVDCILFTIIAPIAPALLYHIEYGRGNRTFKNSSGQYPVSNYD 72

  Fly    75 -------LRDNITGKIIPVHHD---------------HHGQD------SATGILFASKAIVQLMV 111
                   |.|:..|.    :||               :.|:|      ...|:|.|.||.:||:.
Frog    73 SIFNLSHLEDSRKGP----YHDQIINITESPGDKKNCYEGKDFLNEENVRVGLLLAIKAFLQLLF 133

  Fly   112 NPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAGSAFADTAGLAMIADR 176
            ||..|.|:.:||||.||..|..|:..||.:||..:||::|..||..||.||:|.....|..:|..
Frog   134 NPIVGKLVTRIGYDAPMFFGFVIVVVSTLLFAFANSYALLCVARGFQGIGSSFTMVPALGTLAQV 198

  Fly   177 FTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVCLLDGLMLLLVMKPVKE 241
            |.::.||.:|:|:|::.::.|.|..||||.|:|:|.||..|||::|.:.||||.:...|:||.|.
Frog   199 FPDDVERGKAMGLAMSGVAIGVLAGPPFGSAMYEFVGKSSPFLVIAALALLDGALQCCVLKPTKF 263

  Fly   242 AMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWL 306
            :.....:...:|     ||.||||.|.|..|.:.|.:...:||||.:.|.:.|.:..:::|:.:|
Frog   264 SPLSVPETPYRV-----LLTDPYIVVAAVGLCICNFSFGIMEPTIPIRMMETMCSPPYQLGLAFL 323

  Fly   307 PAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALI 371
            |....:.:.:.:....|.|.  .:||....|:...|.|...:|.......|:.|...:..|..|.
Frog   324 PCMLAYFICLNLFAGFAHKI--GRWLCIMIGMMALGISVLCLPLARNIFGLIAPQAGVGIGFGLF 386

  Fly   372 DTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGFTALNFLIAFSNLAY 436
            :|::.|.:.:|||:|:.|.||:||||:||:..|.||:||...|.:.:|||||.|..::...||.|
Frog   387 ETSMFPMMAHLVDIRHTSNYGAIYAISDIALCIGYALGPSCGGAIAKAIGFTWLMVILGIINLVY 451

  Fly   437 VPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMHDQKPVEGGVKNHLEYGQQYQQEQE 498
            .|:.                 ||:::||.||       :..||         ..|:..||||
Frog   452 APLF-----------------ILLRNPPGKE-------ETMPV---------LSQEETQEQE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	118/342 (35%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	61/139 (44%)
slc18a1	XP_012814578.1	MFS_SLC18A1_2_VAT1_2	21..459	CDD:340942	149/465 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930