Protein Alignment VAChT and slc18a2

DIOPT Version :10

• Sequence 1: NP_477138.1
• Gene: VAChT / 42795
• FlyBaseID: FBgn0270928
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_001243154.1
• Gene: slc18a2 / 553304
• ZFINID: ZDB-GENE-080514-1
• Length: 515
• Species: Danio rerio
• Alignment Length: 552
• Identity: 193/552 - (34%)
• Similarity: 285/552 - (51%)
• Gaps: 98/552 - (17%)

  Fly    13 VREVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDD--------- 68
            :|:...:.|  ::|....|||||:||.|||||||||..|:|||||.||..:   ||
Zfish     7 LRDFSLLTW--LREERQSRRLILLIVFIALLLDNMLLTVVVPIIPSYLYTV---DDEAAQMVKNH 66

  Fly    69 --GPTPP--------PLRDN---ITG-----------KIIPVHHDHHGQDSA------------- 96
              .|..|        .|.||   :||           .:.|.......|...
Zfish    67 SMTPLSPSSTFQSIVSLYDNTTRVTGFSPQMSTAGPMSLAPTFVSPQNQSDCPKADDQLLNENVK 131

  Fly    97 TGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAG 161
            .|:||||||.|||:.|||.|.|.::|||.:||..|..|||.||.:||..|||::||.||||||.|
Zfish   132 VGLLFASKATVQLITNPFIGPLTNRIGYQIPMFAGFCIMFVSTIMFAFSSSYTLLFLARSLQGVG 196

  Fly   162 SAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVCL 226
            |:.:..||:.|:|..:|::.||..|:||||..::.|.||.||||..:|:|.||..||||||::.:
Zfish   197 SSCSSVAGMGMLASVYTDDEERGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAV 261

  Fly   227 LDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWME 291
            |||.:.|.|::|.|...:..|...     :..|:.||||.:.||::..:|:|:|.|||.:.:||.
Zfish   262 LDGALQLFVLQPSKVEPESQKGTS-----LITLMKDPYILIAAGSICFANMAIAMLEPALPIWMM 321

  Fly   292 DNMTTDNWKIGMVWLPAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKM 356
            :.|....|::|:.::||...:::|..|...:|.|  ..:||.:..|:.|.|.|...:|.......
Zfish   322 ETMCPRKWQLGIAFVPASISYLIGTNIFAVLAHK--MGRWLCSLIGMLLVGISILCVPLAKDIYG 384

  Fly   357 LMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIG 421
            |::|...:.|.|.::|::::|.:|||||:|:||||||:|||||:::.:.:|:||...|.:..:||
Zfish   385 LIVPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGFALGPSAGGAIARSIG 449

  Fly   422 FTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMHDQKPVEGGVKNH 486
            |..|..:|...::.:.|:...|||                .|.|:|....:|
Zfish   450 FPWLMTIIGLVDIMFAPLCFFLRN----------------PPANEEKMAILM------------- 485

  Fly   487 LEYGQQYQQEQETNLDDQQYEYQQQQQGYQQG 518
                       ::|...:...|..|...||.|
Zfish   486 -----------DSNCSMKTRSYSTQGSSYQMG 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_SLC18A3_VAChT	35..444	CDD:340941	173/454 (38%)
slc18a2	NP_001243154.1	MFS_SLC18A1_2_VAT1_2	26..472	CDD:340942	174/455 (38%)