DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VAChT and Slc18a2

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_037163.1	Gene:	Slc18a2 / 25549	RGDID:	3694	Length:	515	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	198/547 - (36%)
Similarity:	290/547 - (53%)	Gaps:	91/547 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VKDIV---WEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYL----REIGSFDDGPTPP 73
            :.|:|   |  :::..:.|:|||.||.:||||||||..|:|||||.||    .|..|.:...|.|
  Rat     3 LSDLVLLRW--LRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRP 65

  Fly    74 PL-------------------RDNITG--------KIIPVHH----------------DHHGQDS 95
            .|                   ..|.||        |.....|                |...::.
  Rat    66 ELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENV 130

  Fly    96 ATGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGA 160
            ..|:||||||.|||:.|||.|.|.::|||.:||..|..|||.||.:||..|||:.|..||||||.
  Rat   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGI 195

  Fly   161 GSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVC 225
            ||:.:..||:.|:|..:|::.||..|:||||..::.|.||.||||..||:|.||..|||:||.:.
  Rat   196 GSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALV 260

  Fly   226 LLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWM 290
            ||||.:.|.|::|.:...:..|..     |:..||.||||.:.||::..:|:.:|.|||.:.:||
  Rat   261 LLDGAIQLFVLQPSRVQPESQKGT-----PLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWM 320

  Fly   291 EDNMTTDNWKIGMVWLPAFFPHVLGV----VITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFC 351
            .:.|.:..|::|:.:|||...:::|.    ::..||.|      ||.|..|:.:.|.|...|||.
  Rat   321 METMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR------WLCALLGMVIVGISILCIPFA 379

  Fly   352 SGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGV 416
            .....|:.|...:.|.|.::|::::|.:|||||:|:||||||:|||||:::.:.||:||...|.:
  Rat   380 KNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAI 444

  Fly   417 VEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMHDQK-PVE 480
            .:||||..|..:|...::|:.|:...||:                 ||.||.:..::.|.. |::
  Rat   445 AKAIGFPWLMTIIGIIDIAFAPLCFFLRS-----------------PPAKEEKMAILMDHNCPIK 492

  Fly   481 GGVKNHLEYGQQYQQEQETNLDDQQYE 507
            ..:     |.|...|..... ||::.|
  Rat   493 TKM-----YTQNNVQSYPIG-DDEESE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	139/341 (41%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	75/139 (54%)
Slc18a2	NP_037163.1	MFS_SLC18A1_2_VAT1_2	124..472	CDD:340942	149/358 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830