DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VAChT and SPCC18.02

DIOPT Version :9

Sequence 1:	NP_477138.1	Gene:	VAChT / 42795	FlyBaseID:	FBgn0270928	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_588381.1	Gene:	SPCC18.02 / 2538923	PomBaseID:	SPCC18.02	Length:	448	Species:	Schizosaccharomyces pombe

Alignment Length:	458	Identity:	111/458 - (24%)
Similarity:	193/458 - (42%)	Gaps:	85/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VNQRR---LILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDDGPTPPPLRDNITGKIIPVHHD 89
            |.|||   .|:..::|||..|..||.:|.||:|..|.:    ..|.:|    |.:
pombe     7 VKQRRSLPFIIGTIAIALFTDLFLYGIITPILPFSLVD----RVGISP----DRV---------- 53

  Fly    90 HHGQDSATGILFASKAIVQLMVNPFSGGLIDK-IGYDLPMMIGLTIMFFSTAVFACGSSYSVLFF 153
                .|....|.|..|:..:..:...|.|.|| :...:||:|||..:..:||:...|:|..:|..
pombe    54 ----QSVISTLLAVYAVANIAASSPIGFLADKFLTRKVPMLIGLIFLTSATALLTFGNSVPMLIV 114

  Fly   154 ARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPF 218
            ||.|||..:|...|.|||::.|....:|..|...|| ..|||.|.::||.|||.:|:..|....|
pombe   115 ARVLQGLSAAVVWTVGLALLVDVVGADNVGSTMGGI-FGFISLGEIIAPVFGGIVYESLGYYASF 178

  Fly   219 LILALVCLLDGLMLLLVMKP------------VKEAMKQSKDVQDQ-------------VIPIWR 258
            .:..::.|||..:..|:::|            .:.::.|.:|.||.             .:||:.
pombe   179 GVCFIILLLDIALRFLMIEPREMKNDSTLQDVERTSILQRQDTQDHELKPKRSGLFSSLCLPIYS 243

  Fly   259 LLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVW----LPAFFPHV-LGVVI 318
            ||....|........:::...:..:.||.|.::.....::.:.|:::    .|.||... .|.::
pombe   244 LLHHKQIFGPFWTSFVNSCLFSAFDATIPLELKTLFDFNSLQCGLMFGVLSTPYFFCGAWAGAMV 308

  Fly   319 TVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIAL--IDTALLPTLGY 381
            ..:.:|...:..:       |:.|.:.|::  |.......|.|.:....:|:  :..|...:.|:
pombe   309 DRRGSRTIGKRAY-------AILGCTLFLL--CIPRTNTSLNIYLFSAFLAINGVVLAFTSSPGF 364

  Fly   382 LVDVRYVS--------------VYGSIYAIADISYSIAYAVGPIIAGGVVEAIGF---TALNFLI 429
            :....||:              .|..:::..:|.||:...:||::||.:.:...|   .|...|:
pombe   365 VQSSHYVAEYELEHPTFFGHNGPYTQLFSAYNIVYSLGMIIGPLVAGFLRDQFNFITSIACLSLL 429

  Fly   430 AFS 432
            .||
pombe   430 CFS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAChT	NP_477138.1	MFS_1	88..410	CDD:284993	83/368 (23%)
VAChT	NP_477138.1	2_A_01_02	98..238	CDD:273318	48/140 (34%)
SPCC18.02	NP_588381.1	MFS	17..437	CDD:119392	106/448 (24%)
SPCC18.02	NP_588381.1	MFS_1	20..407	CDD:284993	97/418 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	1.000	Domainoid score	I2277
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I1778
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	1	1.000	-	-		otm46977
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2004
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.950