DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10254 and UBC23

DIOPT Version :9

Sequence 1:	NP_651170.1	Gene:	CG10254 / 42793	FlyBaseID:	FBgn0027512	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001324377.1	Gene:	UBC23 / 816195	AraportID:	AT2G16920	Length:	1102	Species:	Arabidopsis thaliana

Alignment Length:	1405	Identity:	329/1405 - (23%)
Similarity:	517/1405 - (36%)	Gaps:	449/1405 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SRRSGGGQVPSKAQGNTESQFFL-------EDGVFRIDRRGRVHFGLVTATTETYSSSEEEDVD- 118
            ::::|...|.|:..|:::|...:       :|.....|....|..|...:.....:...|:..|
plant    45 NKKTGSVGVVSEVAGDSDSDSDISDEEEDDDDDEDNDDDDEDVEEGKKASEENVVNGDGEKKADG 109

  Fly   119 -----SLSRGEVRVAFYPGGKEMVMTEQSIGLADRTLMPGDVVRRRLPGENVLAGQAGYVRDVNV 178
                 :|...::|| .:....|.|.....:.:.||..:.||.|    ...:...||.|.|.|||:
plant   110 NYKCGALEGDQIRV-LWMDNTEPVQDINDVTVIDRGFLHGDYV----ASASEPTGQVGVVVDVNI 169

  Fly   179 RADVMVM-GSRMVIKNVPAERLRPISEW--NQYVPLCMDTWIGTIIDINECAVLKSSNGA----- 235
            ..|::.. ||  :.|::..:.|:.:.::  ..||  ....|:|.|.|:.:...:...:|:
plant   170 SVDLLAPDGS--IHKDISTKNLKRVRDFAVGDYV--VHGPWLGRIDDVLDNVTVLFDDGSMCKVL 230

  Fly   236 RVE------ITSNDFHKFKDAVSECDRTVFNPNV-FFPGNIVIGRMPPPDRVKNLTPEI------ 287
            |||      |..|:..  :||           |. ::||          .|||..:..:
plant   231 RVEPLRLKPIPKNNLE--EDA-----------NFPYYPG----------QRVKASSSSVFKNSRW 272

  Fly   288 THPLTRKGRAVYTVESVETTSINVDWSCRAIGNATGSDDTDSDPLKEPRSLIKGEELHKVKRLSL 352
            ...|.:..|...||..|...||.|.|...|   ..|.|.:.|.|.::..|        .:..||.
plant   273 LSGLWKPNRLEGTVTKVTAGSIFVYWIASA---GFGPDSSVSPPEEQNPS--------NLTLLSC 326

  Fly   353 YESYELQIHDRFYLKYSKCDLLVKYADWENEQAEKYIPIFHAQKKMQRKASKLNASASTSGNARS 417
            :.....|:                 .||      ..:|             .||.||       :
plant   327 FTHANWQV-----------------GDW------CLLP-------------SLNQSA-------T 348

  Fly   418 VPKFRRMPNKISGMRLPRPPSDQTHNACKSSKRSKEDVLTSEDEDEFEEFMQPLDQSMTAEKEVE 482
            :|    :...:|.:||....:|:.    :...|..|||     :||....::|  ..:|||...:
plant   349 IP----LHKHVSKLRLYDSQADRQ----QKIGRDLEDV-----QDEVSGKVEP--AGITAEALPK 398

  Fly   483 VAEDALPPSAATTAAAGVEVQAPRITMRSAKRRQVKKKIRSVKKTIYSPFNKKETTPKDGDEIVV 547
            |..|  .|.....:.:...|..|....|...|:.|.:|.:.|||.               :|...
plant   399 VTSD--DPPQRNPSVSKEPVHEPWPLHRKKIRKLVIRKDKKVKKK---------------EESFE 446

  Fly   548 ETLVVYSS---VTVVWQDGTVESGVHSTQLYPIHHLDNHEFFPGDFVT-KANDISTGATD---YG 605
            :.|:|.:|   |.|.|||||:|....:..|.||....:|||....:|. |.:|.....|:   .|
plant   447 QALLVVNSRTRVDVSWQDGTIECRREAITLIPIETPGDHEFVSEQYVVEKTSDDGDNTTEPRRAG 511

  Fly   606 VIQCVDHDARIAKVMWFNIYTNIDNPIPLFKGLEELSVYDMKDHTDYQYRPGTVVIRVS------ 664
            |::.|:...|.|.|.|.|.....:.|.. |:..|.:|||:::.|.||.|..|.||:|:|
plant   512 VVKNVNAKDRTASVRWLNPLRRAEEPRE-FEKEEIVSVYELEGHPDYDYCYGDVVVRLSPIAVAL 575

  Fly   665 -----------------NFTGEDVNSTAGQVIDNYPN--------------------GRVRVWWA 692
                             .:...:.:..|..::|...|                    |.:.|.||
plant   576 PASSPGNSFEEATQQDNGYQDSESHQEAKILVDKEENEPSTDLSKLSWVGNITGLKDGDIEVTWA 640

  Fly   693 KGHITLCYPQDLFQPFEQDEQNEQDQDVYGSDGSEDSWETESENSHISSSD--NDDDILTGIDRA 755
            .|.|:...|..::              |.|.|..::|...|||.|..:|.:  ||||
plant   641 DGTISTVGPHAVY--------------VVGRDDDDESVAGESETSDAASWETLNDDD-------- 683

  Fly   756 TEAMKVLEKMFRVLHPNRKAEVLYDLLDVYKNCRALDRLLNTKFFDEFNFKGIVRCKPITSKVCS 820

plant   684 ----------------------------------------------------------------- 683

  Fly   821 DSATHERATPETPETSAAVPKESSTLQAELEPVLMDPSVQSSSSPTKRKSSTEMDEVLCKKSTDE 885
                  |..||.||                                         |.|.:.|:.|
plant   684 ------RGAPEIPE-----------------------------------------EDLGRSSSIE 701

  Fly   886 ISEEQDYQVEVVEVIEDPPLVREYRCKYNEMFANARRSI-AKAIENRTKNDSGVHSRGEITSDES 949
            .:.:.|...|                  |:...|...:: ..|||..|:..||:.||...:.|.|
plant   702 GNSDADIYAE------------------NDSGRNGALALPLAAIEFVTRLASGIFSRARKSVDSS 748

  Fly   950 NNHPDSENKLDIKHPTINVMDDLEIELVASGDADVCEVFCYLIKFQMARIRKTVAVTLGKTNDNP 1014
            ::....||.......| |..|:.:                                    :.|:|
plant   749 SSDYTVENVYKQAEST-NPSDETD------------------------------------SLDDP 776

  Fly  1015 KQEKEDVSDAEEAIEAVSQEAELANDGATECNTMAEDEAMEEPLNLNALSESLPAIDQTGPMACS 1079
            ...|.:|:|   ..|:...:|...|..:.|.:|..|||  ::|:
plant   777 SPSKVNVTD---NCESKGTQANAKNILSGETSTFLEDE--DKPV--------------------- 815

  Fly  1080 SPSWSIIPDTPSVDENC----FQVLPNAPAAHNFISNLITPANKAQYQRAVQREYLMLKSSLPNG 1140
                      ||..::|    |.:..: |..|:|:........:.|:.:.|.:::.:|:::||:|
plant   816 ----------PSEGDSCSFRRFDISQD-PLDHHFLGVDGQKTKERQWFKKVDQDWKILQNNLPDG 869

  Fly  1141 VVVRAYEDRMDLMSVMMVGPKRTPYQNALFFFDFQFGRDYPKSPPVCHYISYCTDRLNPNLYEGG 1205
            :.||||||||||:..::||...||||:.||||||....|||..||..:|.|... ||||||||.|
plant   870 IFVRAYEDRMDLLRAVIVGAFGTPYQDGLFFFDFHLPSDYPSVPPSAYYHSGGW-RLNPNLYEEG 933

  Fly  1206 RVCVSLLGTWMGRDNEVWSP-SSTMLQVLVSIQGLILVDEPYYNEAGYEKQRGTQLGNENSRVYN 1269
            :||:|||.||.||.||||.| ||::||||||:|||:|..:||:|||||:||.||..|.:||..||
plant   934 KVCLSLLNTWTGRGNEVWDPKSSSILQVLVSLQGLVLNSKPYFNEAGYDKQVGTAEGEKNSLGYN 998

  Fly  1270 EMAIIKIAQSTVKQLTNPPLIFRNELIEHFKEFGTELYARMRAWSEYSLEAQRQNITKIKDMPVE 1334
            |...:...::.:..:..||..|...:.:||::.|   |..::|...|.......::||...: ::
plant   999 ENTFLLNCKTMMYLMRKPPKDFEELIKDHFRKRG---YYILKACDAYMKGYLIGSLTKDASV-ID 1059

  Fly  1335 YKASCELPEFPLLPCSRGFCIAVKRVLSQLQSELTALGAN 1374
            .::|..       ..|.||.:.:.::..:|.|.|:.:||:
plant  1060 ERSSAN-------STSVGFKLMLAKIAPKLFSALSEVGAD 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10254	NP_651170.1	UQ_con	1126..1272	CDD:278603	86/146 (59%)
UBC23	NP_001324377.1	UBCc	857..980	CDD:238117	72/123 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	163	1.000	Domainoid score	I1236
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I789
OMA	1	1.010	-	-		QHG60077
OrthoDB	1	1.010	-	-		D808738at2759
OrthoFinder	1	1.000	-	-		FOG0005714
OrthoInspector	1	1.000	-	-		otm2847
orthoMCL	1	0.900	-	-		OOG6_105055
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1047
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830