DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10254 and birc6

DIOPT Version :9

Sequence 1:	NP_651170.1	Gene:	CG10254 / 42793	FlyBaseID:	FBgn0027512	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_021328806.1	Gene:	birc6 / 796547	ZFINID:	ZDB-GENE-091202-7	Length:	4929	Species:	Danio rerio

Alignment Length:	1534	Identity:	329/1534 - (21%)
Similarity:	523/1534 - (34%)	Gaps:	504/1534 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PGG----TPGQPQQEQEQSLAEAAPRTPTLANPPPSSQELGRTPNQESRHNANSHSRRS--GGGQ 69
            |.|    |..:|....:.|        |:..|.||.|.||.....:......|||:.:.  ||.:
Zfish  3701 PSGFSSQTERRPYSHNQHS--------PSSTNRPPLSPELAAPVLRFLTEVGNSHTMKDWLGGPE 3757

  Fly    70 VPSKAQGN---TESQFFLEDGVFRIDRRGRVH---FGLVTATTETYSSSEEEDVDSLSRGEVRVA 128
            |      |   |...|.|            .|   .|...|...:.|||......|.|......|
Zfish  3758 V------NPLWTALLFLL------------CHSSASGTANANANSSSSSVCGHGASPSTSHASAA 3804

  Fly   129 FYPGGKEMVMTEQSIGLADRTLMPGDVVRRRLPGENVLAGQAGYVRDVNVRADVMVMGSRMVIK- 192
            .:..|       .|..||..:...|...::|...||  |..|.:::.::...:...:.::::.:
Zfish  3805 PHTSG-------ASYSLASSSRSSGLTTQQRTAIEN--ATVAFFLQCISCHPNNQRLMAQVLCEL 3860

  Fly   193 --------NVPA--------ERLRPISEWNQYVPLCMDTWIGTIIDINECAVLKSSNGARVEITS 241
                    |||.        .||        ::.|.::....|:...:.|.:.|    .|:..||
Zfish  3861 FQSAPQRGNVPVSGNISGFIRRL--------FLQLMLEDEKVTVFLQSPCPLYK----GRINATS 3913

  Fly   242 NDF--------HKFKDAVSECDRTVFNPNVFFPGNIVIGRMPPPDRVKNLTPEITHPLTRKGRAV 298
            :..        |||:             .:..|.:..:..:  .|||.: ||.||..|
Zfish  3914 HVIQHPMYGAGHKFR-------------KLHLPISTTLSEV--LDRVSD-TPSITAKL------- 3955

  Fly   299 YTVESVETTSINVDWSCRAIGNATGSDDTDSDPLKEPRSLIKGEELHKVKRLSLYESYELQIHDR 363
                      ||..                    ||.:.....||..|:|           ..:.
Zfish  3956 ----------INEQ--------------------KEDKEKKNHEEKEKMK-----------ADNG 3979

  Fly   364 FYLKYSKCDLLVKYADWENEQAEKYI--PIFHAQKKMQRKASKLNASASTSGNAR--SVPKFRRM 424
            |...||     |..|.....|:::.:  |.....::.:..:.||.||:....:|:  |||.|...
Zfish  3980 FQDNYS-----VVVASGLKSQSKRALSTPPRPPSRRGRVLSDKLAASSGVDPSAKTISVPVFHLC 4039

  Fly   425 PNKISGMRLPRPP----------------------------------SDQTHNACKSSKRSKEDV 455
            ...:.|.  |.||                                  ||...:...|.||.:
Zfish  4040 HKLLPGQ--PLPPEMTLAQLLTLLYERKLPQGYRSIDLTVKLGSKIISDPGLSKTDSFKRLR--- 4099

  Fly   456 LTSEDEDEF------EEFMQPLDQSMTAEKEVEVAEDA--LPPSAATTAAAGVEVQAPRITMRSA 512
             |.:|..|.      :|.|.|.|:.:.|..:..:.|.:  ..|........|:.:.|.|:.|
Zfish  4100 -TEKDHCEMLSGCPDDEPMTPGDEGLDAAVDDSLLETSPIQSPLQVFAGMGGLALIAERLPM--- 4160

  Fly   513 KRRQVKKKIRSVKKTIYSPFNKKETTPKDGDE---IVVE---TLVVYSSVTVVWQDGTVESGVHS 571
               .....|:.|...:. |...:| .|||.|:   :.:|   .||..:..|:..:...::|.|.:
Zfish  4161 ---LYPDVIQQVSAPVV-PSTTQE-KPKDSDQFEWVTIEQSGELVYEAPETIAAEPPPIKSSVQT 4220

  Fly   572 TQLYPIHHLDNHEFF---PG--DFVTKAND-------ISTGATDYG----VIQCVDHDARIAKVM 620
            ....|.|.|.....|   ||  :.:.|...       :..|.||.|    ::|  ...|.:...:
Zfish  4221 MSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQ--SPSANVLPTL 4283

  Fly   621 WFNIYTNIDNPIPLFKGLEELSVYDMKDHTDYQYRPGTVVIRVSNFTGE---------------- 669
            .|::..::.:..||              .||    .|.::.|::...|.
Zfish  4284 PFHVLRSLFSSTPL--------------TTD----DGLLLRRMALEIGAIHLILACLSALSHHAP 4330

  Fly   670 -----DVNSTAGQVIDNYPNGRV---RVWWAKGHITLCYPQDLFQPFEQDEQNEQDQDVYGSDGS 726
                 ..||:..||...:..|..   :::||||                        ..:|:..:
Zfish  4331 RVPSGSANSSEPQVSSGHVGGTTEEQQLYWAKG------------------------TGFGTGST 4371

  Fly   727 EDSWETES-------ENSHISSSDNDDDILTGIDRATEAMKVLEKMFRVLHPNRKAEVLYDLLDV 784
            ...|:.|.       |..|::.                   :|:.:...::|:
Zfish  4372 ASGWDVEQALTKQRLEEEHVTC-------------------LLQVLASYINPS------------ 4405

  Fly   785 YKNCRALDRLLNTKFFDEFNFKGIVRCKPITSKVCSDSATHERATPETPETSAAVPKESSTLQAE 849
              .|......|.          |.||        ...|:.......|....|..:|..||.|:.:
Zfish  4406 --GCVGSGETLT----------GEVR--------GHSSSLLPSVLQELLSQSCLIPAMSSYLRND 4450

  Fly   850 --LEPVLMDPSVQSSSSPTKRKSS-TEMDEVLCKKSTDEISEEQDYQVEVVEVIEDPPLVREYRC 911
              |:.....|..::.....:..|: |.:..:|...|.|...||:|.:....:......|.:...|
Zfish  4451 SVLDMARHVPLYRALLELLRAISTCTSLVPLLLPLSGDAAEEEEDEERIECQTSVGMLLAKMKTC 4515

  Fly   912 KYNEMFANARRSIAKAIENRTKNDSGVHSRGEITSDESNNHPDSENKLDIKHPTINVMDDLEIEL 976
            .  :.:.|..||         |.|.   |:|.:.::.|:..|:.        .|:.|.|
Zfish  4516 V--DTYTNRLRS---------KKDK---SKGVMKAETSDPEPEG--------LTLLVPD------ 4552

  Fly   977 VASGDADVCEVFCYLIKFQMARIRKTVAVTLGKTNDNPKQEKEDVSDAEEAIEAVSQEAELANDG 1041
                                  |:||..:....|. |.:|...:...||.:.:|.
Zfish  4553 ----------------------IQKTAEIVYAATT-NLRQANHERKMAESSKKAA---------- 4584

  Fly  1042 ATECNTMAEDEAMEEPLN-LNALSESLPAIDQ-----TGPMACSSPSWSIIPDTPSVDENCFQVL 1100
                       |..:||: |.::.|...|..:     |..|.|......::          |:|
Zfish  4585 -----------ARPKPLSILRSMEEKYTAAMKKLQFDTFEMVCEDEDSKLV----------FKV- 4627

  Fly  1101 PNAPAAHNFISNL--ITPANKAQYQRAVQREYLMLKSSLP----NGVVVRAYEDRMDLMSVMMVG 1159
                 .::::|.:  .:.||.|...|.:.:|.:.|.:|||    :.|.||..|:|:|:|.|::.|
Zfish  4628 -----NYHYLSQVKNASDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITG 4687

  Fly  1160 PKRTPYQNALFFFDFQFGRDYPKSPPVC-------HYISYCTDRLNPNLYEGGRVCVSLLGTWMG 1217
            |..|||.|..|.||..|.:|||.|||:.       |.:     |.|||||..|:||:|:|.||.|
Zfish  4688 PADTPYANGCFEFDVYFPQDYPNSPPLVNLETTGGHSV-----RFNPNLYNDGKVCLSILNTWHG 4747

  Fly  1218 RDNEVWSP-SSTMLQVLVSIQGLILVDEPYYNEAGYEKQRGTQLGNENSRVYNEMAIIKIAQSTV 1281
            |..|.|:| :|:.||||||||.||||.|||:||.|||:.|||..|.::||.|:.    .|.|:||
Zfish  4748 RPEEKWNPQTSSFLQVLVSIQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDG----NIRQATV 4808

  Fly  1282 K-----QLTNPPLIFRNELIEHFKEFGTELYARMRAW----SEYSLEAQRQNITKIKDMPVEYKA 1337
            |     |:.||...|:..:..||.....|:.|:..:|    .:||.: :|...|.........:.
Zfish  4809 KWAMLEQMRNPSPCFKEVIHRHFYLKRAEIMAQCESWICDIQQYSSD-KRVGRTMSHHAAALKRH 4872

  Fly  1338 SCELPEFPL-LPCSRGF------------CIAVKRVLSQ 1363
            :.:|.|..| |||..|.            .:.||.:.||
Zfish  4873 TAQLREELLKLPCPEGLEPDGEEFSEKSTSLMVKELPSQ 4911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10254	NP_651170.1	UQ_con	1126..1272	CDD:278603	76/157 (48%)
birc6	XP_021328806.1	BIR	246..319	CDD:237989
		BIRC6	3501..3664	CDD:315107
		UBCc	4669..4807	CDD:238117	73/146 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810