DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10254 and Bruce

DIOPT Version :9

Sequence 1:	NP_651170.1	Gene:	CG10254 / 42793	FlyBaseID:	FBgn0027512	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster

Alignment Length:	1367	Identity:	277/1367 - (20%)
Similarity:	465/1367 - (34%)	Gaps:	434/1367 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 IGTIIDINECAVLKSSNGARVEITSNDFHKFKDAVSECDRTVFNPNVFFP-----------GNIV 270
            ||.||    |..|:.|:|.|..|:..........:.|.:....:.....|           |.|.
  Fly  3833 IGAII----CKPLRFSHGVRPTISGFTRQMVLQLLLENEHITVSVRSQQPLQRRDTLSAVLGGIS 3893

  Fly   271 IGRMP--PPDRVKNLTPEITHPLTRKG--RAVYTVESVETTSINVDWSC---------------R 316
            .|...  |...|.|      ||..|..  ..::|| :..||...:..:|               |
  Fly  3894 SGASTSLPVAAVNN------HPARRSSAHHMLFTV-TTSTTCQEIMQNCVSVFSNLVYQQPTDQR 3951

  Fly   317 AIGNATGSDDTDSDPLKEPRSLIKGEELHKVKRLSLYESYELQIHDRFYLKYSKC----DLLVKY 377
            |...:..|....|...|...|        |:::.|......::.....:|.....    |..:|
  Fly  3952 AGETSASSSGVSSATAKSSES--------KMEKSSFLNFNNVEAGSMEFLTVGAAVAAKDKRIK- 4007

  Fly   378 ADWENEQAEKYIPIFHAQKKMQRKASKLNASASTSGNARSVPKF-RRMPNKISGMRLPRP----- 436
             |.:|:.|            |.:......:|.:.:.|..:|.:| .:..|.::|.:|..|
  Fly  4008 -DAKNQAA------------MNKDKETQTSSTNLASNIFNVDEFLLQSANAVNGNQLVIPEYSDI 4059

  Fly   437 --PSDQTHNACKSSKRSKEDVLTSEDEDEFEEFMQPLDQSMTAEKEVEVAEDALP-PSAATTAAA 498
              ..|.|.:...:|.::....|::..........|..|.:..|:|......:.|| |....:::.
  Fly  4060 VLAGDATISQVLASLQNAGHSLSTPCISFDLVLQQRSDDTSEAKKTKAACTEPLPSPLQRFSSSG 4124

  Fly   499 GVEVQA---PRITMRSAKRRQVKKKIRSVKKTIYSPFNKKETTPKDGDEIVVE-TLVVYSSVTVV 559
            |:.:.|   |.:....:.|          |.|:.  |::||.:|...|.:.:| ...:|..:
  Fly  4125 GLSLLAHYLPTVYPEHSGR----------KTTLV--FSEKEKSPPLSDWVKLEPNDEIYEDL--- 4174

  Fly   560 WQDGTVESGVHSTQLYPIHHLDNHEFFP-GDFVTKANDISTGATDYGVIQCV---------DHD- 613
             :|...|.   :.:|..:..:..|.... |.|:...........|....||:         |.|
  Fly  4175 -EDTLCEP---AAKLATVSSVPQHSLAAFGLFLRLPAYSDVLLRDKMRAQCLLRLVLGVTGDGDG 4235

  Fly   614 --------ARIAKVMWFNIYTNIDNPIPLFKG------------------LEELSVYDMKDHTDY 652
                    |.....:.|.::..:.:.:||...                  |..|.::..:.|.:.
  Fly  4236 NDIYSLSLAPSLPTLPFEVFRQLLDSVPLSTDDGVLLRRVVIEVGAMHLVLNCLGIFSHQSHNNR 4300

  Fly   653 QYRPGTVVIRVSNFTGEDVNSTAGQVIDNYPNGRV---------------------RVWWAKGHI 696
            ...|      :|..:....:|.:|.:.:...||.|                     .::||||
  Fly  4301 IGAP------ISEPSPSGTSSGSGTIGNGSGNGSVSGTKTNAPEEATPSATSDDKSHMYWAKG-- 4357

  Fly   697 TLCYPQDLFQPFEQDEQNEQDQDVYGSDGSEDSWETE-------SENSHISSSDNDDDILTGIDR 754
                                  ..:|:..:..||..|       ||..|::
  Fly  4358 ----------------------TGFGTGSTTQSWNVEQALLRQKSEEEHVT-------------- 4386

  Fly   755 ATEAMKVLEKMFRVLHPNRKAEVLYDLLDVYKN---CRALDRLLNTKFFDEFNFKGIVRCKPITS 816
                                  ||..:|..|.|   |                         |.|
  Fly  4387 ----------------------VLLLVLASYINPGDC-------------------------IPS 4404

  Fly   817 KVCSDS--ATHE--RATPETP-------ETSAAVPKESSTLQAE--LEPVLMDPSVQSSSSPTKR 868
            ::|.:.  |.|:  ..|.|.|       :.|..:|..||.|:.:  |:.....|..::.....:.
  Fly  4405 EMCGEDILAYHDVRDVTGELPPIFQTLLQQSCLIPALSSYLRNDSVLDITRHIPLYRAILKLLRA 4469

  Fly   869 KSSTEMDEVLCKKSTDEISEEQDYQVEVVEVIEDPPLVREYRCKYNEMFANARRSI---AKAIE- 929
            .|.::|...|.:.|.....:            ..||:|        |:..:.:..:   ||.::
  Fly  4470 LSLSKMLVSLLQPSASGSGD------------STPPIV--------ELLTSMKTCVDTYAKRLKV 4514

  Fly   930 NRTKNDSGVHSRGEITSDESNNHPDSENKLDIKHPTINVMDDLEIELVASGDADVCEVFCYLIKF 994
            |:..|..|            ..|          ..|.|: ||.:.|.:|....|:.|
  Fly  4515 NKKSNIKG------------QTH----------QLTFNI-DDGDDEGLALLIPDIHE-------- 4548

  Fly   995 QMARIRKTVAVTLGKTNDNPKQEKEDVSDAEEAIEAVSQEAELANDGATECNTMAEDEAMEEPLN 1059
                    .:|.:.||           :||:..|..:              :|..:..|..||.:
  Fly  4549 --------TSVLVQKT-----------TDADALINML--------------HTNEDGSAQLEPQS 4580

  Fly  1060 LNALSESLPAIDQTGPMACSSPSWSIIPDTPSVDENCFQVLPNAPAAHNFISNLITPANKAQYQR 1124
            .:.....|..:.:.     ...::.:|.::   |.|.|:.:    .:|:| ..::..|....:..
  Fly  4581 KSIEQRYLELMKKR-----QFDTFDMIVES---DNNSFRFV----VSHHF-EKMVRLAGDRYHPS 4632

  Fly  1125 AVQR---EYLMLKSSLP----NGVVVRAYEDRMDLMSVMMVGPKRTPYQNALFFFDFQFGRDYPK 1182
            .|:|   |.:.|.:|||    :.|.||...||:|:|.|::.||..|||.|..|.||..|..|||.
  Fly  4633 RVKRLAQEAVTLSTSLPLSFSSSVFVRCDTDRLDIMKVLITGPADTPYANGCFEFDVFFPPDYPN 4697

  Fly  1183 SPPVC-------HYISYCTDRLNPNLYEGGRVCVSLLGTWMGRDNEVW-SPSSTMLQVLVSIQGL 1239
            .|.:.       |.:     |.|||||..|:||:|:|.||.||..|.| :.:|:.||||||||.|
  Fly  4698 QPMLINLETTGRHSV-----RFNPNLYNDGKVCLSVLNTWHGRPEEKWNAQTSSFLQVLVSIQSL 4757

  Fly  1240 ILVDEPYYNEAGYEKQRGTQLGNENSRVYNE---MAIIKIAQSTVKQLTNPPLIFRNELIEHFKE 1301
            |||.|||:||.|:|:.||:..|..:||.||.   .|.::.|.  ::|:.:|...|::.:.:||..
  Fly  4758 ILVPEPYFNEPGFERSRGSPSGTNSSREYNSNIYQACVRWAM--LEQIRSPSQCFKDVIHKHFWL 4820

  Fly  1302 FGTELYARMRAWSE------YSLEAQ-----------------RQNITKIK------DMPVEYKA 1337
            ...|:.|::..|.|      |:..|.                 |:.::|:|      |:...:..
  Fly  4821 KREEICAQIEGWIEELGKPQYTERASRTISFNSMVLRRHYRHLREELSKLKPPRGLEDLDAPFNP 4885

  Fly  1338 SCELPEFPLLPCSRGFCIAVKRVLSQ----LQSELTALGANLVTDERNGIATGIGTAP---RAAP 1395
            ...||...:...:.... |...|.:|    :.:::|.||.|....|.:|.|.|.|...   :..|
  Fly  4886 VATLPPMDVSAVAPSLA-ATNTVQAQPDDAIVTDITLLGENADECEADGDAEGDGEVDDGFKGFP 4949

  Fly  1396 EE 1397
            :|
  Fly  4950 QE 4951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10254	NP_651170.1	UQ_con	1126..1272	CDD:278603	74/163 (45%)
Bruce	NP_001262460.1	BIR	251..321	CDD:279047
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603	73/158 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0895
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810