Protein Alignment CG10254 and Birc6

DIOPT Version :10

• Sequence 1: NP_651170.1
• Gene: CG10254 / 42793
• FlyBaseID: FBgn0027512
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001164067.1
• Gene: Birc6 / 313876
• RGDID: 1307247
• Length: 4865
• Species: Rattus norvegicus
• Alignment Length: 1209
• Identity: 267/1209 - (22%)
• Similarity: 442/1209 - (36%)
• Gaps: 361/1209 - (29%)

  Fly   279 RVKNLTPEITHPLTRKGRAVYTVESVETTSINVDWSCRAIGNATGSD--DTDSDPLKEPRSLIKG 341
            |:...:..|.||:...|....|:....:|::              ||  |..||.......||..
  Rat  3842 RINATSHVIQHPMFGAGHKFRTLHLPVSTTL--------------SDVLDRVSDTPSITAKLISE 3892

  Fly   342 EELHKVKRLSLYESYELQIHDRFYLKYSKCDLLVKYADWENEQAEKYI------PIFHAQKKMQR 400
            ::..|.|: :..|..:::..:.|...||     |..|.....|:::.:      |.....:.:..
  Rat  3893 QKDDKEKK-NHEEKEKVKADNGFQDNYS-----VVVASGLKSQSKRAVSSTPPRPPSRRGRAIPD 3951

  Fly   401 KASKLNASASTSGNARSVPKFRRMPNKISGMRLPRPPS-------------DQTHNACKSSKRSK 452
            |....::||.|:....:||.|......::|..||...:             .|.:.:...:.:..
  Rat  3952 KIGSTSSSADTANKIITVPVFHLFHRLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLG 4016

  Fly   453 EDVLTSEDEDEFEEFMQ--------------PLDQSMTAEKEV--EVAEDAL-------PPSAAT 494
            ..|:|.....:.:.|.:              |.|:::|...|.  .|.:::|       .|....
  Rat  4017 SKVITDPSLSKTDSFKRLHPEKDHGELIGSCPEDEALTPSDECMDGVLDESLLETCPIQSPLQVF 4081

  Fly   495 TAAAGVEVQAPRITMRSAKRRQVKKKIRSVKKTIYSPFNKKETTPKDGDE---IVVE---TLVVY 553
            ....|:.:.|.|:.|      ...:.|:.|...:.:...:::  |||.|:   :.:|   .||..
  Rat  4082 AGMGGLALIAERLPM------LYPEVIQQVSAPVVASTTQEK--PKDSDQFEWVTIEQSGELVYE 4138

  Fly   554 SSVTVVWQDGTVESGVHSTQLYPIHHLDNHEFF---PG--DFVTKAND-------ISTGATDYG- 605
            :..|:..:...|:|.|.:|...|.|.|.....|   ||  :.:.|...       :..|.||.|
  Rat  4139 APETIAAEPPPVKSAVQATSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGE 4203

  Fly   606 ---VIQCVDHDARIAKVMWFNIYTNIDNPIPLFKG---------------------LEELSVYDM 646
               ::|  ...|.:...:.|::..::.:..||...                     |..||
  Rat  4204 GSHILQ--SPSANVLPTLPFHVLRSLFSATPLTTDDGVLLRRMALEIGALHLILVCLSALS---- 4262

  Fly   647 KDHTDYQYRPGTVVIRVSNFTGEDVNSTAGQVIDNY-PNG--RVRVWWAKGHITLCYPQDLFQPF 708
                  .:.|     ||.|   ..:|.|..||.::: |..  ..:::||||
  Rat  4263 ------HHAP-----RVPN---SSLNQTEPQVSNSHNPTSTEEQQLYWAKG-------------- 4299

  Fly   709 EQDEQNEQDQDVYGSDGSEDSWETES-------ENSHISSSDNDDDILTGIDRATEAMKVLEKMF 766
                      ..:|:..:...|:.|.       |..|::
  Rat  4300 ----------TGFGTGSTASGWDVEQALTKQRLEEEHVT-------------------------- 4328

  Fly   767 RVLHPNRKAEVLYDLLDVYKNCRALDRLLNTKFFDEFNFKGIVRCKPITSKVCSDSATHERATPE 831
                      .|..:|..|.|                         |::|.|..::    :.:||
  Rat  4329 ----------CLLQVLASYIN-------------------------PMSSAVNGEA----QVSPE 4354

  Fly   832 T-PETSAAVPKESSTLQAELEPVLMDPSVQSSSSPTKRKSSTEMDEVLCKKSTDEISEEQDYQVE 895
            : .:.|:|:|.           ||::...||...|.       |...|...|
  Rat  4355 SRAQNSSALPS-----------VLLELLSQSCLIPA-------MSSYLRNDS------------- 4388

  Fly   896 VVEVIEDPPLVREYRCKYNEMFANARRSIAKAIENRTKNDSGVHSRGEITSDESNNHPDSENKLD 960
            |:::....||.|.. .:.....|:....:...:...|:|       ||...:|.:....|...|.
  Rat  4389 VLDMARHVPLYRAL-LELLRAIASCTSMVPLLLPLSTEN-------GEEEEEEQSECQTSVGTLL 4445

  Fly   961 IKHPTINVMDDLEIELVASGDADVCEVFCYLIKFQMARIR-KTVAVTLGKTNDNPKQEKE----- 1019
            .|..|                       |  :.....|:| |...:..|...|.|.||.|
  Rat  4446 AKMKT-----------------------C--VDTYTNRLRSKRENIKTGVKPDAPDQEPEGLTLL 4485

  Fly  1020 --DVSDAEEAIEAVSQEAELANDGATECNTMAEDEAME-EPLN-LNALSESLPAIDQTGPMACSS 1080
              |:....|.:.|.:.....||. ..:....::..||: :||: |.:|.|...|:.:|    ...
  Rat  4486 VPDIQRTAEIVHAATTNLRQANQ-EKKLGEYSKKVAMKPKPLSVLKSLEEKYVAVMKT----LQF 4545

  Fly  1081 PSWSIIPDTPSVDEN---CFQVLPNAPAAHNFISNL--ITPANKAQYQRAVQREYLMLKSSLP-- 1138
            .::.::    |.|::   .|:|      .::::|.:  ...||.|...|.:.:|.:.|.:|||
  Rat  4546 DTFEMV----SEDDDGKLGFKV------NYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLS 4600

  Fly  1139 --NGVVVRAYEDRMDLMSVMMVGPKRTPYQNALFFFDFQFGRDYPKSPPVC-------HYISYCT 1194
              :.|.||..|:|:|:|.|::.||..|||.|..|.||..|.:|||.|||:.       |.:
  Rat  4601 SSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTGGHSV---- 4661

  Fly  1195 DRLNPNLYEGGRVCVSLLGTWMGRDNEVWSP-SSTMLQVLVSIQGLILVDEPYYNEAGYEKQRGT 1258
             |.|||||..|:||:|:|.||.||..|.|:| :|:.||||||:|.||||.|||:||.|||:.|||
  Rat  4662 -RFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGT 4725

  Fly  1259 QLGNENSRVYNEMAIIKIAQSTVK-----QLTNPPLIFRNELIEHFKEFGTELYARMRAW----S 1314
            ..|.::||.|:.    .|.|:|||     |:.||...|:..:.:||.....|:.|:...|    .
  Rat  4726 PSGTQSSREYDG----NIRQATVKWAMLEQIRNPSPCFKEVIHKHFYLKRVEVMAQCEEWIADIQ 4786

  Fly  1315 EYSLEAQRQNITKIKDMPVEYKASCELPEFPL-LPCSRG 1352
            :||.: :|...|.........:.:.:|.|..| |||.:|
  Rat  4787 QYSSD-KRVGRTMSHHAAALKRHTAQLREELLKLPCPQG 4824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10254	NP_651170.1	UBCc_UBE2O	1120..1316	CDD:467439	91/216 (42%)
Birc6	NP_001164067.1	BIR	292..362	CDD:459891
		Nsa1_WDR74-like	906..>977	CDD:459257
		BIRC6	3470..3624	CDD:463547
		UBCc_BIRC6	4580..4784	CDD:467430	91/212 (43%)