DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10254 and Ube2o

DIOPT Version :9

Sequence 1:	NP_651170.1	Gene:	CG10254 / 42793	FlyBaseID:	FBgn0027512	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_221132.5	Gene:	Ube2o / 303689	RGDID:	1310297	Length:	1291	Species:	Rattus norvegicus

Alignment Length:	1569	Identity:	406/1569 - (25%)
Similarity:	614/1569 - (39%)	Gaps:	468/1569 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MSDVAGAAAPGGTPGQPQQEQEQSLAEAAPRTPT---LANPPPSSQELGRTPNQESRHNANSHSR 63
            |:|.| |.||...|.|.|       |.||| ||.   .|.|||:       |..:|....:|.|.
  Rat     1 MADPA-APAPAPAPAQAQ-------AAAAP-TPAAAPAAAPPPA-------PATDSASGPSSDSG 49

  Fly    64 RSGGGQVPSKAQGNTESQFFLED---GVFRIDRRGRVHFGLVTATTETYSSSE-EED-------- 116
            ...|.|          ...|..|   |.:    ||.||||||.......|.|| |||
  Rat    50 PEAGSQ----------RLLFSHDLVSGRY----RGSVHFGLVRLIHGEDSDSEGEEDGRGSSGCS 100

  Fly   117 -----------VDSLSRGEVRVAFYPGGKEMVMTEQSIGLADRTLMPGDVVRRRLPGENVLAGQA 170
                       ...|.||.|||.:||.|.:..:.|..:.|.||:::|.||||.....::    |.
  Rat   101 EAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDS----QC 161

  Fly   171 GYVRDVNVRADVMVMGSRMVIKNVPAERLRPISEW----NQYVPLCMDTWIGTIIDINECAVLKS 231
            |.|.|||:...|.::|:..:|..|.::.|:.|  |    ..|:  ..|.|:|.:.|:....:||.
  Rat   162 GTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHI--WPFMYGDYI--AYDCWLGKVYDLKNQIILKL 222

  Fly   232 SNGARVEITSNDFHKFKDA---VSECDRTVFNPNVFFPGNIVIGRMPPPDRVKNLTPEITHPLTR 293
            |||||..:.:.|..|..|.   ||:......:...|:||.::||.......|:.|: .:...|:.
  Rat   223 SNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLS-GVKPVLST 286

  Fly   294 KGRAVYTVESVETTSINVDWSCRAIGNATGSDDTDSDPLKEPRSLIKGEELHKVKRLSLYESYEL 358
            |.:....||.|:...:.|.|..::.  ..|.    :|.:..|.|:|..|.|.:||||..::..:.
  Rat   287 KSKFRVVVEEVQVVELKVTWITKSF--CPGG----TDSVSPPPSVIAQENLGRVKRLGCFDHAQR 345

  Fly   359 QIHDRFYLKYSKCDLLVKYADWENEQAEKYIPIFHAQKKMQRKASKLNASASTSGNARSVPKFRR 423
            |:                        .|:.:.:|.|:.:..:.|.:........|......|.:|
  Rat   346 QL------------------------GERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKR 386

  Fly   424 MPNKISGMRLPRPPSDQTHNAC-----------KSSKRSKEDVLTSEDEDEFEEFMQPLDQSMTA 477
            :..|    ::.|..|......|           |...|:..:|.::..|::.:....|::.....
  Rat   387 LLKK----QVVRIMSCTPDAQCSRDHAMEDPDKKGEARAGSEVGSASPEEQLDGSASPVEMQDEG 447

  Fly   478 EKEVEVAEDALPP----------------------------------SAATTAAA------GVEV 502
            .:|:....:.|||                                  ||::|.::      |.:.
  Rat   448 SEELHETGEPLPPFLLKEGGDEGLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTGRKK 512

  Fly   503 QAPRITMRSAKRRQVKKKIRSVKKTIYSPFNKKETTPKDGDEIVVETLVVYSSVTVVWQDGTVES 567
            ..| :::::.||:..:||            ||.....|.||.:.||.:...:|..|:||||:||.
  Rat   513 SIP-LSIKNLKRKHKRKK------------NKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVEC 564

  Fly   568 GVHSTQLYPIHHLDNHEFFPGDFVT-KANDISTGATDYGVIQCVDHDARIAKVMWFNIYTNIDNP 631
            .:.|..|:|:|||||:||.|||||. |..........|||:|..||..|...|.||.:..:.|:
  Rat   565 NIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDD- 628

  Fly   632 IPLFKGLEELSVYDMKDHTDYQYRPGTVVIRVSN-----FTGEDVNSTAGQVIDNYPNGRVRVWW 691
            :.|....|::||||:.||.|:::|...:|||:.|     ...|| ..:.|||.....:.:|.|.|
  Rat   629 VELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGALPKED-EPSVGQVARVDVSSKVEVVW 692

  Fly   692 AKGHITLCYPQDLFQPFEQDEQNEQDQDVYG--SDGSEDSWETESENSHISSSDNDDDILTGIDR 754
            |....|:..||.|:....:.|:::.| .|.|  |..|.|.||.:|::....:...||:
  Rat   693 ADNSKTIILPQHLYNIESEIEESDYD-SVEGSTSGASSDEWEDDSDSWETDNGLVDDE------- 749

  Fly   755 ATEAMKVLEKMFRVLHPNRKAEVLYDLLDVYKNCRALDRLLNTKFFDEFNFKGIVRCKPITSKVC 819
                           ||  |.|.|..:|
  Rat   750 ---------------HP--KIEDLAAIL------------------------------------- 760

  Fly   820 SDSATHERATPETPETSAAVPKESSTLQAELEPVLMDP---SVQSSSSPTKRKSSTEMDEVLCKK 881
               .|.:.|.|| .:....:.:|::|...:....:..|   .::.:......||..|:.|.:
  Rat   761 ---PTEQPAAPE-EDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAI--- 818

  Fly   882 STDEISEEQDYQVEVVEVIEDPPLVREYRCKYNEMFANARRSIAKAIENRTKNDSGVHSRGEITS 946
                                                     .|.::::|.|.......|....|.
  Rat   819 -----------------------------------------KILESLKNMTVEQLLTGSPTSPTV 842

  Fly   947 DESNNHPDSENKLDIKHPTINVMDDLEIELVASGDADVCEVFCYLIKFQMARIRKTVAVTLGKTN 1011
            :...  |..|.|.         :||::                                   |..
  Rat   843 EPEK--PTREKKF---------LDDIK-----------------------------------KLQ 861

  Fly  1012 DNPKQEKEDVSDA-EEAIEAVSQEAELANDGATECNTMAEDEAMEEPLNLNALSESLPAIDQTGP 1075
            :|.|:..::|:.| ||.:|||..         ||                  ..|..|.:.  .|
  Rat   862 ENLKKTLDNVAIAEEEKMEAVPD---------TE------------------RKEDKPEVQ--SP 897

  Fly  1076 MACSSPSWSIIPDTPSVDENC---------------FQVLPNAPAAHNFISNLITPANKAQYQRA 1125
            :....||     :||.:.:.|               |.||..||:.|:|......|....::...
  Rat   898 VKAEWPS-----ETPVLCQQCGGRPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFST 957

  Fly  1126 VQREYLMLKSSLPNGVVVRAYEDRMDLMSVMMVGPKRTPYQNALFFFDFQFGRDYPKSPPVCHYI 1190
            |::|..:|.:|||:|::|:.:||||||.|.::.||.||||::.|:.||.|....||..||...|:
  Rat   958 VRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYL 1022

  Fly  1191 SYCTDRLNPNLYEGGRVCVSLLGTWMGRDNEVWSPSSTMLQVLVSIQGLILVDEPYYNEAGYEKQ 1255
            |.|:.|||||||:.|:|||||||||:|:..|.|:..|::||||:||||||||:||||||||::..
  Rat  1023 SQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSD 1087

  Fly  1256 RGTQLGNENSRVYNEMAIIKIAQSTVKQLTNPPLIFRNELIEHFKEFGTELYARMRAWSE----- 1315
            ||.|.|.||||.|||||:|::.||..:.:..||.:|..|:.:||...|..|..|:.:|.|
  Rat  1088 RGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLETHVVL 1152

  Fly  1316 --------------YSLEAQ---------RQNITKIKDMPVE--------------YKASCELPE 1343
                          .|||.|         |:....:...|.|              ..||.|.||
  Rat  1153 ERAQALPNGVPKDSSSLEPQAAAELSDSGREEPEDVGMTPGEASQGSDSEGGAQGPASASREHPE 1217

  Fly  1344 -------------------------------------FPLLPCSRGFCIAVKRVLSQLQSELTAL 1371
                                                 |||.|.|:||..:::.||:|.::.|...
  Rat  1218 QTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEA 1282

  Fly  1372 GANLVTDER 1380
            |....|:::
  Rat  1283 GMPESTEDK 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10254	NP_651170.1	UQ_con	1126..1272	CDD:278603	84/145 (58%)
Ube2o	XP_221132.5	UBCc	958..1108	CDD:238117	87/149 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3128
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1535
OMA	1	1.010	-	-		QHG60077
OrthoDB	1	1.010	-	-		D38527at33208
OrthoFinder	1	1.000	-	-		FOG0005714
OrthoInspector	1	1.000	-	-		oto95752
orthoMCL	1	0.900	-	-		OOG6_105055
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1047
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870