DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPE and f10

DIOPT Version :9

Sequence 1:	NP_651168.1	Gene:	SPE / 42791	FlyBaseID:	FBgn0039102	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_958870.3	Gene:	f10 / 282670	ZFINID:	ZDB-GENE-021206-9	Length:	504	Species:	Danio rerio

Alignment Length:	412	Identity:	109/412 - (26%)
Similarity:	167/412 - (40%)	Gaps:	117/412 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DERGQCVH---------ITSCPYLANLLMVEPKTPAQRILLSKS-------QCGLDNRVEGLVNR 89
            :|.|.|.|         :.||   ||...:.|.        .||       :||
Zfish   128 NENGGCDHFCEVMEKNVVCSC---ANGYELAPN--------GKSCQSQDPFKCG----------- 170

  Fly    90 ILVCCPQSMRG------NIMDSEPTPSTR----------------------------DALQQGDV 120
              |..|:..|.      ||.:||....|.                            :.:::..:
Zfish   171 --VIYPKKTRSIFFHTPNITESENEEETELEATIEPVYNHSNPLNNQTDSMFGLHELEIIEEEPI 233

  Fly   121 LPGNDVCGFLFADRIFGGTNTTLWEFPWMVLLQYKKLFSETYTFNCGGALLNSRYVLTAGHCLAS 185
            ||.....|   ..||..|......:.||..|     |.:|.....|||.:|...::|:|.||
Zfish   234 LPVVSTAG---DGRIVNGVECPPGDCPWQAL-----LINENNMGFCGGTILTEHFILSAAHC--- 287

  Fly   186 RELDKSGAVLHSVRLGEWDTRTDPDCTTQMNGQRICAPKHIDIEVEKGIIHEMYAPNSVDQRNDI 250
              :::|.::  .|.:||:||.. |:            .:....:|::.:||:.|.|::  ..|||
Zfish   288 --MNESLSI--RVVVGEYDTLV-PE------------GREATHDVDEILIHKNYQPDT--YHNDI 333

  Fly   251 ALVRLKRIVSYTDYVRPICLPTDGLVQNNFV--DYGMDVAGWG-LTENMQPSAIKLKITVNVWNL 312
            ||::|.:.:.:|.|:.|.|||.....:...:  |.|: |:|:| :.|....|.|..|:||...|.
Zfish   334 ALIKLSKPIKFTKYIIPACLPEMKFAERVLMQQDDGL-VSGFGRVREGGLSSTILQKLTVPYVNR 397

  Fly   313 TSCQEKYSSFKVKLDDSQMCAG-GQLGVDTCGGDSGGPLMVPISTGGRDVFYIAGVTSYGTKPCG 376
            ..|.|. |:||:  .....||| .|...|.|.||||||.:    |..::.::|.||.|:| :.|.
Zfish   398 AKCIES-SNFKI--SGRMFCAGYDQEEKDACQGDSGGPHV----TRFKNTWFITGVVSWG-EGCA 454

  Fly   377 LKGWPGVYTRTGAFIDWIKQKL 398
            .||..||||:...:|.||...:
Zfish   455 RKGKYGVYTQVSKYIMWINNAM 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPE	NP_651168.1	CLIP	42..94	CDD:314844	14/67 (21%)
SPE	NP_651168.1	Tryp_SPc	135..397	CDD:238113	84/265 (32%)
f10	NP_958870.3	GLA	19..82	CDD:214503
		EGF_CA	83..119	CDD:238011
		FXa_inhibition	126..161	CDD:291342	10/43 (23%)
		Tryp_SPc	244..472	CDD:214473	83/263 (32%)
		Tryp_SPc	245..474	CDD:238113	84/264 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920