DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPE and F10

DIOPT Version :9

Sequence 1:	NP_651168.1	Gene:	SPE / 42791	FlyBaseID:	FBgn0039102	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	307	Identity:	93/307 - (30%)
Similarity:	144/307 - (46%)	Gaps:	57/307 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DSEPTPSTRDAL-------QQGDVLPGNDVCGFLFADRIFGGTNTTLWEFPWMVLLQYKKLFSET 161
            |.:||.:..|.|       ::||    |::      .||.||......|.||..||    :..|.
Human   207 DLDPTENPFDLLDFNQTQPERGD----NNL------TRIVGGQECKDGECPWQALL----INEEN 257

  Fly   162 YTFNCGGALLNSRYVLTAGHCLASRELDKSGAVLHSVRLGEWDTRTDPDCTTQMNGQRICAPKHI 226
            ..| |||.:|:..|:|||.|||...:..|       ||:|:.:|..:.      .|:.:    |
Human   258 EGF-CGGTILSEFYILTAAHCLYQAKRFK-------VRVGDRNTEQEE------GGEAV----H- 303

  Fly   227 DIEVEKGIIHEMYAPNSVDQRNDIALVRLKRIVSYTDYVRPICLPTDGLVQNNFVDY--GMDVAG 289
              |||..|.|..:...:.|  .|||::|||..:::...|.|.|||.....::..:..  |: |:|
Human   304 --EVEVVIKHNRFTKETYD--FDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI-VSG 363

  Fly   290 WGLTENMQPSAIKLK-ITVNVWNLTSCQEKYSSFKVKLDDSQMCAG-GQLGVDTCGGDSGGPLMV 352
            :|.|......:.:|| :.|...:..||  |.||..: :..:..||| .....|.|.||||||.:
Human   364 FGRTHEKGRQSTRLKMLEVPYVDRNSC--KLSSSFI-ITQNMFCAGYDTKQEDACQGDSGGPHV- 424

  Fly   353 PISTGGRDVFYIAGVTSYGTKPCGLKGWPGVYTRTGAFIDWIKQKLE 399
               |..:|.:::.|:.|:| :.|..||..|:||:..||:.||.:.::
Human   425 ---TRFKDTYFVTGIVSWG-EGCARKGKYGIYTKVTAFLKWIDRSMK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPE	NP_651168.1	CLIP	42..94	CDD:314844
SPE	NP_651168.1	Tryp_SPc	135..397	CDD:238113	84/265 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	84/264 (32%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920