Protein Alignment SPE and F10

DIOPT Version :10

• Sequence 1: NP_651168.1
• Gene: SPE / 42791
• FlyBaseID: FBgn0039102
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 93/307 - (30%)
• Similarity: 144/307 - (46%)
• Gaps: 57/307 - (18%)

  Fly   104 DSEPTPSTRDAL-------QQGDVLPGNDVCGFLFADRIFGGTNTTLWEFPWMVLLQYKKLFSET 161
            |.:||.:..|.|       ::||    |::      .||.||......|.||..||    :..|.
Human   207 DLDPTENPFDLLDFNQTQPERGD----NNL------TRIVGGQECKDGECPWQALL----INEEN 257

  Fly   162 YTFNCGGALLNSRYVLTAGHCLASRELDKSGAVLHSVRLGEWDTRTDPDCTTQMNGQRICAPKHI 226
            ..| |||.:|:..|:|||.|||...:..|       ||:|:.:|..:.      .|:.:    |
Human   258 EGF-CGGTILSEFYILTAAHCLYQAKRFK-------VRVGDRNTEQEE------GGEAV----H- 303

  Fly   227 DIEVEKGIIHEMYAPNSVDQRNDIALVRLKRIVSYTDYVRPICLPTDGLVQNNFVDY--GMDVAG 289
              |||..|.|..:...:.|  .|||::|||..:::...|.|.|||.....::..:..  |: |:|
Human   304 --EVEVVIKHNRFTKETYD--FDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI-VSG 363

  Fly   290 WGLTENMQPSAIKLK-ITVNVWNLTSCQEKYSSFKVKLDDSQMCAG-GQLGVDTCGGDSGGPLMV 352
            :|.|......:.:|| :.|...:..||  |.||..: :..:..||| .....|.|.||||||.:
Human   364 FGRTHEKGRQSTRLKMLEVPYVDRNSC--KLSSSFI-ITQNMFCAGYDTKQEDACQGDSGGPHV- 424

  Fly   353 PISTGGRDVFYIAGVTSYGTKPCGLKGWPGVYTRTGAFIDWIKQKLE 399
               |..:|.:::.|:.|:| :.|..||..|:||:..||:.||.:.::
Human   425 ---TRFKDTYFVTGIVSWG-EGCARKGKYGIYTKVTAFLKWIDRSMK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPE	NP_651168.1	CLIP	36..94	CDD:463440
		Tryp_SPc	135..397	CDD:238113	84/265 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:464251
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	84/264 (32%)
		O-glycosylated at one site	476..485