DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3d1 and Eif3d

DIOPT Version :9

Sequence 1:	NP_524463.2	Gene:	eIF3d1 / 42789	FlyBaseID:	FBgn0040227	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_061219.2	Gene:	Eif3d / 55944	MGIID:	1933181	Length:	548	Species:	Mus musculus

Alignment Length:	542	Identity:	316/542 - (58%)
Similarity:	404/542 - (74%)	Gaps:	13/542 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGIQ 78
            |..|.:|.|..|||||.:|:.|:|:|||||||.|||||:.|||..:..||:|.|||:|.||.|.|
Mouse     4 FMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQ 68

  Fly    79 YSYYHEEDETTFHLVDTARVQKPPHQRGRFR-NMRNSRSGRGRNARGGLNTHGMTTL--SGKNVK 140
            |:|:||||||:|.||||||.||..:||.|.| ..||.|..:.|......|   :.||  |.|..:
Mouse    69 YAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMVQFN---LQTLPKSAKQKE 130

  Fly   141 ARDPRHGRGMGKKFGHR----GPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGVDIVT 201
            ....|..:...|:||.|    ....|.|:|||.||:||...||||||:|:|:....:.|..||..
Mouse   131 RERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIEC 195

  Fly   202 CGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTR 266
            ||.||||||.:|||..::||||:.|.||.||||||||||||:|:||.||||||||||||:|..||
Mouse   196 CGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTR 260

  Fly   267 SNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQ 331
            |.||||||:::||.|:|.||||:::||||||:|::.|||.|:.:|.|||||||:|||:|||||||
Mouse   261 SVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQ 325

  Fly   332 QVLKTGDQEPKYKFEESNPFISEDED-IQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGEP 395
            |.|:.|.:  :|.|...|||:.:|.| .::|||.|||::|:||.||.|:.|||||||:...:||.
Mouse   326 QCLRMGRE--RYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEV 388

  Fly   396 QFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVS 460
            .|:.||.||||||:..|||:||||||:|||||:|.||:||:.|||:||..|:||||:.|||||||
Mouse   389 SFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVS 453

  Fly   461 RINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNKPIIR 525
            |.:.:|.|||||||||||||:|||:|||||::||||||||:||:.||.::|||||:|||||.:||
Mouse   454 RYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIR 518

  Fly   526 LYDIPDNTFDSDDSDDGEGDDE 547
            :|.:||.||.|::.::.|.::|
Mouse   519 VYSLPDGTFSSEEDEEDEEEEE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d1	NP_524463.2	eIF-3_zeta	14..528	CDD:282888	308/521 (59%)
Eif3d	NP_061219.2	eIF-3_zeta	4..521	CDD:398661	308/521 (59%)
		RNA gate. /evidence=ECO:0000250\|UniProtKB:K7IM66	285..299		8/13 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..548		7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849987
Domainoid	1	1.000	624	1.000	Domainoid score	I177
eggNOG	1	0.900	-	-		E1_KOG2479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2782
Inparanoid	1	1.050	644	1.000	Inparanoid score	I802
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53861
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004086
OrthoInspector	1	1.000	-	-		otm43124
orthoMCL	1	0.900	-	-		OOG6_102252
Panther	1	1.100	-	-	LDO	PTHR12399
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R379
SonicParanoid	1	1.000	-	-		X2834
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790