DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3d1 and eif3d

DIOPT Version :9

Sequence 1:	NP_524463.2	Gene:	eIF3d1 / 42789	FlyBaseID:	FBgn0040227	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_956310.1	Gene:	eif3d / 336498	ZFINID:	ZDB-GENE-030131-8442	Length:	552	Species:	Danio rerio

Alignment Length:	546	Identity:	322/546 - (58%)
Similarity:	407/546 - (74%)	Gaps:	18/546 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGIQ 78
            |..|.:|.|..|||||.:|:.|||:|||||||.|||||:.|||..:..||:|.|||:|.||.|.|
Zfish     4 FHAPVIQDNPSGWGPCAVPEKFKDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQ 68

  Fly    79 YSYYHEEDETTFHLVDTARVQKPPHQRGRFR-NMRNSRSGRGRNARGGLNTHGMTTL--SGKNVK 140
            |:|:|||||.:|.|||||:.||..:||.|.| ..||.|..:.|..   |....|.||  |.|. |
Zfish    69 YAYFHEEDEASFQLVDTAKTQKTAYQRNRMRFAQRNLRRDKDRRT---LTQFNMQTLPKSAKQ-K 129

  Fly   141 ARD-PRHGRGMGKKFGHR-------GPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGV 197
            .|| .|..:...|:||.|       ....|.|:|||.||:||...||||||||:|:...::.:.:
Zfish   130 ERDRMRLQKKFQKQFGVRQKWDQKSQAQLKPRDSSVEVRSDWEVKEEMDFPRLMKMRYMDVADPL 194

  Fly   198 DIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIM 262
            ||..||.||:|||.:|||..:|||||:.|.||.||||||||||||:|:||.||||||||||||:|
Zfish   195 DIECCGALEHYDKAFDRITTRNEKPLKSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLM 259

  Fly   263 CSTRSNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINH 327
            |.|||..||||::::||:|:|.||||:::||||||:|::.|||.|:.||.|||||||:|||:|||
Zfish   260 CCTRSVNSWDIIVQRVGNKLFFDKRDNSDFDLLTVSETANEPPQDEGSSLNSPRNLAMEATYINH 324

  Fly   328 NFSQQVLKTGDQEPKYKFEESNPFISED-EDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTP 391
            |||||.|:.|.:  :|||...|||:.|| |..:||||.|||::|:||.||.|:.|||||||:...
Zfish   325 NFSQQCLRMGGE--RYKFPNPNPFVEEDTEKSEVASVAYRYRRWKLGEDIDLIVRCEHDGVMTGA 387

  Fly   392 SGEPQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKL 456
            :||..|:.:|.||||||:..|||:||||||:|||||||.||:||:.|||:||..|:||||:.|||
Zfish   388 NGEVSFINVKTLNEWDSRYCNGVDWRQKLDSQRGAVLATELKNNSYKLARWTCCAILAGSEYLKL 452

  Fly   457 GYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNK 521
            |||||.:.:|.||||:||||||||:|||:||||||:||||||||:||:..|..:|||||:|||||
Zfish   453 GYVSRYHVKDSSRHVVLGTQQFKPNEFASQINLSMENAWGILRCVIDICRKLDEGKYLILKDPNK 517

  Fly   522 PIIRLYDIPDNTFDSDDSDDGEGDDE 547
            .:||:|.:||.||.||:.::.:.:||
Zfish   518 QVIRVYSLPDGTFSSDEDEEEDDEDE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d1	NP_524463.2	eIF-3_zeta	14..528	CDD:282888	313/525 (60%)
eif3d	NP_956310.1	eIF-3_zeta	4..524	CDD:282888	313/525 (60%)
		RNA gate. /evidence=ECO:0000250\|UniProtKB:K7IM66	288..302		8/13 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..552		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595818
Domainoid	1	1.000	631	1.000	Domainoid score	I167
eggNOG	1	0.900	-	-		E1_KOG2479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2782
Inparanoid	1	1.050	653	1.000	Inparanoid score	I767
OMA	1	1.010	-	-		QHG53861
OrthoDB	1	1.010	-	-		D1030308at2759
OrthoFinder	1	1.000	-	-		FOG0004086
OrthoInspector	1	1.000	-	-		otm26595
orthoMCL	1	0.900	-	-		OOG6_102252
Panther	1	1.100	-	-	LDO	PTHR12399
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R379
SonicParanoid	1	1.000	-	-		X2834
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800