DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31145 and Fam20c

DIOPT Version :9

Sequence 1:	NP_001356923.1	Gene:	CG31145 / 42784	FlyBaseID:	FBgn0051145	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_085042.2	Gene:	Fam20c / 80752	MGIID:	2136853	Length:	579	Species:	Mus musculus

Alignment Length:	531	Identity:	235/531 - (44%)
Similarity:	303/531 - (57%)	Gaps:	82/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 MLHEFKRKFLQKSNASGSKEASTQAGASQSGGATSGQDAAAGASGGAAGPG-------------- 568
            :|.:..|:..:.|...|...|...|.|:..|.|.:.......|.|.|..|.
Mouse    29 LLPKLDRRATRSSGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDP 93

  Fly   569 ----TS-----------------RSTSTRKPTPHD-RYADLQK-----------------HLLSD 594
                ||                 |....|.|.|.| .:..|.:                 .||:.
Mouse    94 ASNLTSHSLEKLPSAAEPVDHAPRGQEPRSPPPRDPAHRPLLRDPGPRPRVPPPGPSGDGSLLAK 158

  Fly   595 EYSHVIVDNA-PDVSRD------------NPTLAE--------------MLHRKASANA-SNLER 631
            .:.|.:...| |.::.|            ||..||              :...:|:.|. .|..:
Mouse   159 LFEHPLYQGAVPPLTEDDVLFNVNSDIRFNPKAAENPDWPHEGAEGAEFLPTGEAAVNLYPNWLK 223

  Fly   632 FQLRITKKELYGEQDTLVDAVLRDMIKLPIQHVVQKEGGTQLKLIIEYPNDIKALMKPMRFPREQ 696
            |.:.|.:.|||...:..:||:|||:....|..|..|.||||||||:.:.|..:||.|||:..|||
Mouse   224 FHIGINRYELYSRHNPAIDALLRDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQ 288

  Fly   697 QTLPNHFYFTDYERHNAEIAAFHLDRILGFRRAMPVAGRTLNITTEIYQLA-EENLLKTFFVSPS 760
            :|.|:.|||:||||||||||||||||||.|||..|||||.:|:|.||..:. ::.|.:||||||:
Mouse   289 ETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPA 353

  Fly   761 LNLCFHGKCSYYCDTSHAICGNPDMLEGSFAAFLPNFESGNRKLWRHPWRRSYHKRKKAQWETDA 825
            .|:||:|:|||||.|.||:||.||.:|||.|||||:.....||.||:||||||||||||:||.|.
Mouse   354 NNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDP 418

  Fly   826 NYCALVRDIPPYDDGRRLYDLMDMAVFDFLTGNMDRHHYETFKVYGNETFPLHLDHGRGFGRPFH 890
            :||..|:..||||.|.|:.|:|||.|||||.|||||||||||:.:|||||.:|||:|||||:..|
Mouse   419 DYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSH 483

  Fly   891 DELSILAPVLQCCLIRKSTLVKLLDFHNGPKPLSQLMSESLSQDPVSPVLWQPHLEALDRRTGII 955
            ||||||||:.|||.||:||.::|.........||.||:|||..|.|:|||:|.||||||||..|:
Mouse   484 DELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIV 548

  Fly   956 LQSIRDCIKRN 966
            ||::|||::::
Mouse   549 LQAVRDCVEKD 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31145	NP_001356923.1	Fam20C	755..971	CDD:336477	134/212 (63%)
Fam20c	NP_085042.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..79		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..155		6/50 (12%)
		FAM20C_C	349..560	CDD:198462	133/211 (63%)
		Kinase domain. /evidence=ECO:0000250\|UniProtKB:Q8IXL6	349..560		133/211 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838021
Domainoid	1	1.000	301	1.000	Domainoid score	I1412
eggNOG	1	0.900	-	-		E1_KOG3829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227822at33208
OrthoFinder	1	1.000	-	-		FOG0004028
OrthoInspector	1	1.000	-	-		otm44033
orthoMCL	1	0.900	-	-		OOG6_107364
Panther	1	1.100	-	-	O	PTHR12450
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4404
SonicParanoid	1	1.000	-	-		X1341
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.740