Protein Alignment CG31145 and FAM20C

DIOPT Version :10

• Sequence 1: NP_001356923.1
• Gene: CG31145 / 42784
• FlyBaseID: FBgn0051145
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_064608.2
• Gene: FAM20C / 56975
• HGNCID: 22140
• Length: 584
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 230/490 - (46%)
• Similarity: 297/490 - (60%)
• Gaps: 40/490 - (8%)

  Fly   514 GGGGMLHEFKRKFLQKSNASGSKEASTQAGASQSGGATSGQDAAAGASGGA------------AG 566
            |..|..::...:.||..::..|...|:.:.......|...:.|..|...||            ..
Human    78 GDAGWPNKHTLRILQDFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDPAHRPLLRD 142

  Fly   567 PGTSRSTSTRKPTP------------HDRY---------ADLQKHLLSD-EYSHVIVDNAPDVSR 609
            ||..||.|  .|.|            |..|         .|:..::.|| ..|....:| ||...
Human   143 PGPRRSES--PPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSPKAAEN-PDWPH 204

  Fly   610 DNPTLAEMLHRKASANAS--NLERFQLRITKKELYGEQDTLVDAVLRDMIKLPIQHVVQKEGGTQ 672
            .....||.|....:|..|  |..:|.:.|.:.|||...:..::|:|.|:....|..|..|.||||
Human   205 AGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRHNPAIEALLHDLSSQRITSVAMKSGGTQ 269

  Fly   673 LKLIIEYPNDIKALMKPMRFPREQQTLPNHFYFTDYERHNAEIAAFHLDRILGFRRAMPVAGRTL 737
            ||||:.:.|..:||.|||:..|||:|.|:.|||:||||||||||||||||||.|||..|||||.:
Human   270 LKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMV 334

  Fly   738 NITTEIYQLA-EENLLKTFFVSPSLNLCFHGKCSYYCDTSHAICGNPDMLEGSFAAFLPNFESGN 801
            |:|.||..:. ::.|.:|||:||:.|:||:|:|||||.|.||:||.||.:|||.|||||:.....
Human   335 NMTKEIRDVTRDKKLWRTFFISPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLSLAK 399

  Fly   802 RKLWRHPWRRSYHKRKKAQWETDANYCALVRDIPPYDDGRRLYDLMDMAVFDFLTGNMDRHHYET 866
            ||.||:||||||||||||:||.|.:||..|:..||||...|:.|:|||.:||||.||||||||||
Human   400 RKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSSHRILDVMDMTIFDFLMGNMDRHHYET 464

  Fly   867 FKVYGNETFPLHLDHGRGFGRPFHDELSILAPVLQCCLIRKSTLVKLLDFHNGPKPLSQLMSESL 931
            |:.:|||||.:|||:|||||:..|||||||.|:.|||.|||||.::|.........||.||:|||
Human   465 FEKFGNETFIIHLDNGRGFGKYSHDELSILVPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESL 529

  Fly   932 SQDPVSPVLWQPHLEALDRRTGIILQSIRDCIKRN 966
            ..|.|:|||:||||||||||..::|:::|||::||
Human   530 RGDQVAPVLYQPHLEALDRRLRVVLKAVRDCVERN 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31145	NP_001356923.1	Fam20C	755..971	CDD:461992	132/212 (62%)
FAM20C	NP_064608.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..81		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..159		14/66 (21%)
		FAM20C_C	354..565	CDD:198462	131/211 (62%)
		Kinase domain. /evidence=ECO:0000305|PubMed:22582013	354..565		131/211 (62%)