DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31145 and FAM20A

DIOPT Version :9

Sequence 1:	NP_001356923.1	Gene:	CG31145 / 42784	FlyBaseID:	FBgn0051145	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_060035.2	Gene:	FAM20A / 54757	HGNCID:	23015	Length:	541	Species:	Homo sapiens

Alignment Length:	554	Identity:	202/554 - (36%)
Similarity:	285/554 - (51%)	Gaps:	98/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 KERLVISLGATLVLLTLLLIVDVQMDFGVANRHLLQQQHQKIR----------------LGND-- 508
            ::||:     ||:||..||..|:..       ||..|..:::|                |..|
Human     6 RDRLL-----TLLLLGALLSADLYF-------HLWPQVQRQLRPRERPRGCPCTGRASSLARDSA 58

  Fly   509 ---YDGGTGGGGMLHEFKRKFLQKSNASGSKEASTQAGASQSGGATSGQDAAA------------ 558
               .|.||    ::|.|.|          ::..:..||.|.||.::..|...|
Human    59 AAASDPGT----IVHNFSR----------TEPRTEPAGGSHSGSSSKLQALFAHPLYNVPEEPPL 109

  Fly   559 -GASGGAAGPGTSRSTSTRKPTPHDRYADLQKHLLSDEYSHVIVDNAPDVSRDNPTLAEMLHRKA 622
             ||.........:.....||....:|     :|.:..|..::       .|.|.|.   .|..:|
Human   110 LGAEDSLLASQEALRYYRRKVARWNR-----RHKMYREQMNL-------TSLDPPL---QLRLEA 159

  Fly   623 SANASNLERFQLRITKKELYGEQDTLVDAVLRDMIKLPIQHV-----------------VQKEGG 670
            |     ..:|.|.|.:..||.....:|..:|:||...|....                 :.|..|
Human   160 S-----WVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDCTQIVKPSG 219

  Fly   671 TQLKLIIEYPNDIKALMKPMRFPREQQTLPNHFYFTDYERHNAEIAAFHLDRILGFRRAMPVAGR 735
            ..|||::.:.:..||:.||||..|:::|..:.|||.|::|||||||||||||||.|||..|..||
Human   220 VHLKLVLRFSDFGKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGR 284

  Fly   736 TLNITTEIYQLAEENLLKT-FFVSPSLNLCFHGKCSYYCDTSHAICGNPDMLEGSFAAFLPNFES 799
            .:|:|.||.::.:..:|:: |||||:.|:||..||.|.|.|.:|:||||.:||||.:||||:...
Human   285 IVNVTKEILEVTKNEILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNL 349

  Fly   800 GNRKLWRHPWRRSYHKRKKAQWETDANYCALVRDIPPYDDGRRLYDLMDMAVFDFLTGNMDRHHY 864
            ..|....:||.|||....|.:||.:..||..|:.|.||::.:||.:::|||:||||.||||||||
Human   350 APRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQRLLNVIDMAIFDFLIGNMDRHHY 414

  Fly   865 ETFKVYGNETFPLHLDHGRGFGRPFHDELSILAPVLQCCLIRKSTLVKLLDFHNGPKPLSQLMSE 929
            |.|..:|::.|.:|||:.|||||..|||:|||:|:.|||:|:|.||:.|.........||.:|.|
Human   415 EMFTKFGDDGFLIHLDNARGFGRHSHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRE 479

  Fly   930 SLSQDPVSPVLWQPHLEALDRRTGIILQSIRDCI 963
            ||.:|.:||||.:|||.|||||...||:::..||
Human   480 SLLEDQLSPVLTEPHLLALDRRLQTILRTVEGCI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31145	NP_001356923.1	Fam20C	755..971	CDD:336477	108/209 (52%)
FAM20A	NP_060035.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..90		13/65 (20%)
FAM20A	NP_060035.2	FAM20A_C	306..522	CDD:198460	107/208 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227822at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41984
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12450
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.810