DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10182 and CG4576

DIOPT Version :9

Sequence 1:	NP_651158.1	Gene:	CG10182 / 42780	FlyBaseID:	FBgn0039091	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_650495.1	Gene:	CG4576 / 41914	FlyBaseID:	FBgn0038366	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	153/711 - (21%)
Similarity:	267/711 - (37%)	Gaps:	175/711 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MLCLSDLTALTTGLQSGQYWALKMFDSWGSIPSGLLTGNMYDLGNFDECLNINHGVSLGRTIQGK 132
            ||.:..|.|..|..|..|   |.|...:...|       :|||.::|.||...:|.:      ..
  Fly     8 MLHIVILAATFTAAQCFQ---LNMTQFYEMPP-------LYDLDDYDRCLQELNGQA------ST 56

  Fly   133 YCFL--------SVSLAQALGVQSSIIGH------FKTATCLPASCSATY--------------- 168
            |||:        ||:..:|:...|....|      .....|| ..|.|:.
  Fly    57 YCFVRAEVQPDESVAAWRAIAEISQYDRHHFDHRQLYFGLCL-RECEASLAGLNKSELEALQAGL 120

  Fly   169 ------MNTFMGM-------------VTKQLLNVS--------IPSSVMSISESSCQTSESVPWD 206
                  :|.::.:             :|...||..        :..||:...:.:....|...|:
  Fly   121 LSENAKVNVYLDLFSMEANNRQRHQRLTNACLNWRLQRRGFGVLAKSVVEYCDEAGHQVEDDAWN 185

  Fly   207 GLTIF----MIVILSVMGSLVALF---TLWDYCLGKNQDQLPT--------IVKVFSARVNSRAL 256
             ||.:    .:::|:.:||||.|.   :..|..| |.:|...|        ::..||.   :|..
  Fly   186 -LTFYGILGTLLVLACLGSLVDLHLKRSRHDKML-KERDHYKTPPKSTAQQVLLTFSV---ARNW 245

  Fly   257 FRIVEVNSSPN--------VIDCLHGIRCLSLMWVVFCHQYVMAALASNINIFH-AISWEETP-- 310
            :|:   |..|:        .:||   .:..::..|:|.|        :|..|:. |||..:.|
  Fly   246 YRL---NQEPSGKIGRELRFLDC---FKFFAMFMVIFAH--------TNWVIYESAISNPQDPER 296

  Fly   311 -----YASFILHGFFSVDSFFVLGGLLVALIPLRMMDRTKGKLNV------PLMY----LHRLIR 360
                 ..:.::.|.....:|||:.|||:.:..|.:....:.|.:.      .|::    :.|.||
  Fly   297 LLHTAAGTLLVSGSLITVTFFVISGLLLTINWLAVSRSLESKKDTWSFGQYALLFVKFNIFRYIR 361

  Fly   361 IVPLLAIAIVM---YLKLMPIVADGPRFGSGYS-GTVDCENGWYWTLLFVNNY--TEEKCLGHTW 419
            :....|..::|   |.:    .|.||.:...:. ..:.|...|:..||:|||:  |:|:||...|
  Fly   362 LTVPYAFVLLMSGVYFE----NAGGPLWRHIFEREQLACRRNWWTNLLYVNNFVRTDERCLLQGW 422

  Fly   420 YLSVDMQLFILSPIMLI---ALYKWGKKAAAGIFVLIVLLSGCLFATIMVNKYSLVLKNFSMDAQ 481
            ||:.|...|:||.::|:   ...:|.|:..|||..|.|::.  :..|..:|.|.:.:.  :...|
  Fly   423 YLAADTHSFVLSLVLLMLGHRFVRWSKQLYAGILGLFVVVP--MVLTYAMNYYPIFVP--TPQTQ 483

  Fly   482 KDLYFATHTHATPWLTGFL-FG-----------------YSLHLNRGKKFQLSKVVAWSGWILCL 528
            ||.:.........:.:.|: ||                 ....|...|.|||.       |...:
  Fly   484 KDSFIGDRQFTEFYTSSFMNFGSYFCGVLAALVYDQLALKQYKLRELKSFQLL-------WFTLI 541

  Fly   529 AMIFTSIFALYPYAKWTGPDLSTFAEASYYTLTRVGWCMALCWVIFACMNGYGGLANSFLSSPLW 593
            .:....:|:.:|..:......|....|.|..|.|..|...|...|....:..|.:...|...|::
  Fly   542 PVGILWLFSAHPIFQHYYVTPSAIWGALYAGLQRNIWGFGLGIFIVGMASKVGWIFRKFCCLPIF 606

  Fly   594 QPLSRLSYSVYMWHMFFQEINIRSMRTNSYFSNYTIMLNFWSTFGFAVLFAYVMHLVIEAP 654
            :.|.||:|..::.|:....|.:.::|...||....:....:.|...:.|.::::.:.:|.|
  Fly   607 RILGRLTYGAFIVHLLVARIVLATVREPIYFGTGMMFAFIFFTVTVSYLCSFLLAIFLELP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10182	NP_651158.1	NRF	85..186	CDD:214781	27/156 (17%)
		Acyl_transf_3	269..645	CDD:280013	95/420 (23%)
		OafA	300..655	CDD:224748	91/400 (23%)
CG4576	NP_650495.1	Acyl_transf_3	260..657	CDD:280013	95/422 (23%)
CG4576	NP_650495.1	OafA	303..668	CDD:224748	86/380 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840