DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10182 and CG14204

DIOPT Version :9

Sequence 1:	NP_651158.1	Gene:	CG10182 / 42780	FlyBaseID:	FBgn0039091	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	343/699 - (49%)
Similarity:	483/699 - (69%)	Gaps:	25/699 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNIVGVVFLCGLGLISAGRL-----------NDEDVLSDLQRVSQLKGLALDFVGQVKDFDVEE 54
            |:.::.::...|:.::. |.|           :|...::|.:|:..|:.||::|..:.::....:
  Fly     1 MIKLLAILLAMGMAMVQ-GALPTQLSNNQWTQHDVSSMADYERLLDLRSLAMEFYREFRNISTAD 64

  Fly    55 LSTLETRVPSQEDMLCLSDLTALTTGLQSGQYWALKMFDSWGSIPSGLLTGNMYDLGNFDECLNI 119
            :..|..|:.|| |:.||:|:....:.|.:.:.|||||.|:||:||||.|.||..|:||:.|||:.
  Fly    65 VHLLGERIGSQ-DLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYRECLSE 128

  Fly   120 NHGVSLGRTIQGKYCFLSVSLAQALGVQSSIIG--HFKTATCLPASCSATYMNTFMGMVTKQLLN 182
            ...::..:.|||||||:.:.:|:.||..|.::.  :.:||.|||:||||..|..|:..:.|:||.
  Fly   129 GGMLTSSQDIQGKYCFMELPVAKWLGFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKRLLG 193

  Fly   183 VSIPSSVMSISESSCQTSESVPWDGLTIFMIVILSVMGSLVALFTLWDYCLGKNQDQLPTIVKVF 247
            ||.|:::.||||:||:..|..||||||||.:|:|||.|..|.|.||:||.|...|::||..:..|
  Fly   194 VSDPTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTLYDYFLCPEQEKLPRPIGAF 258

  Fly   248 SARVNSRALFRIVEVNSSPNVIDCLHGIRCLSLMWVVFCHQYVMAALASNINIFHAISWEETPYA 312
            |||..||:||.|||..::||||.||:|:||:||:||:..|:|::......||....:.|....::
  Fly   259 SARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNLRWATQLFS 323

  Fly   313 SFILHGFFSVDSFFVLGGLLVALIPLRMMDRTKGKLNVPLMYLHRLIRIVPLLAIAIVMYLKLMP 377
            ||||:|..|||:||.:.|||:..|.||.:::.|||||||||||||.:|:.|::|:||:.:.|::|
  Fly   324 SFILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMYLHRYLRLTPIVAVAILAFYKMIP 388

  Fly   378 IVADGPRFGS----GYSGTVDCENGWYWTLLFVNNY-TEEKCLGHTWYLSVDMQLFILSPIMLIA 437
            ::||||.:..    .|||   |:..||||||:|.|| |.:.|:.|||||:|||||:|||||:|||
  Fly   389 LIADGPMYDDIGFFDYSG---CKMTWYWTLLYVQNYATSDVCVPHTWYLAVDMQLYILSPILLIA 450

  Fly   438 LYKWGKKAAAGIFVLIVLLSGCLFATIMVNKYSLVLKN--FSMDAQKDLYFATHTHATPWLTGFL 500
            |||||||||.||.|:.:|||.|||||||||.:.::.||  .:...|:.:|.||||||.|||.|.:
  Fly   451 LYKWGKKAAGGILVVTLLLSACLFATIMVNDFPVMFKNGIQAQVVQRKIYTATHTHAAPWLVGTM 515

  Fly   501 FGYSLHLNRGKKFQLSKVVAWSGWILCLAMIFTSIFALYPYAKWTGPDLSTFAEASYYTLTRVGW 565
            |||.|||.||::|:||.:..|:||:||||.:||||||||||:|..|...|....|.||||.|:.|
  Fly   516 FGYLLHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTLVRIAW 580

  Fly   566 CMALCWVIFACMNGYGGLANSFLSSPLWQPLSRLSYSVYMWHMFFQEINIRSMRTNSYFSNYTIM 630
            .:.||||:||||.|||.|||||||||||||||:|||..|:||:|..|:..||::||:|||||.:|
  Fly   581 PLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWHIFVVEVANRSVQTNTYFSNYQVM 645

  Fly   631 LNFWSTFGFAVLFAYVMHLVIEAPFGGLDYFLRPKQKTPPLVKQKSQID 679
            |||||||||.:|.:||::::||||...|:..:.|.:::||..|.:..|:
  Fly   646 LNFWSTFGFTLLMSYVLYVLIEAPLEALERIMFPNRRSPPAAKDQLHIE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10182	NP_651158.1	NRF	85..186	CDD:214781	48/102 (47%)
		Acyl_transf_3	269..645	CDD:280013	218/382 (57%)
		OafA	300..655	CDD:224748	209/361 (58%)
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	54/114 (47%)
		Acyl_transf_3	280..664	CDD:280013	220/386 (57%)
		OafA	283..687	CDD:224748	226/406 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458064
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750