DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10182 and oac-14

DIOPT Version :9

Sequence 1:	NP_651158.1	Gene:	CG10182 / 42780	FlyBaseID:	FBgn0039091	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_509701.1	Gene:	oac-14 / 181226	WormBaseID:	WBGene00008602	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	720	Identity:	196/720 - (27%)
Similarity:	328/720 - (45%)	Gaps:	101/720 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DLQRVSQLKGLALDFVGQVKDFDVEELSTLETRVPSQEDML----C-LSDLTALTTGLQSGQYWA 88
            |:.:...|.||:...:...:.:    :.:||......|..|    | |.:|..|...|     :|
Worm    24 DIFKPKPLHGLSPQCLNDTQTW----IKSLELFAGVSEACLKKQTCSLKELKILKANL-----YA 79

  Fly    89 LKMFDSWGSIP-SGLL-TGNMYDLGNFDECLNINHGVSLGRTIQGKYCFLSV-----SLAQALGV 146
            ::..||:|.:| .|:| ...:|| |::.||..::     |......||:|.:     :...|.|.
Worm    80 IQELDSFGKLPVPGMLEVATLYD-GSYQECKRVS-----GVKYNTNYCYLMLKPGKNASCSASGS 138

  Fly   147 QSSI-IGHFKTATCLPASCSATYMNTFMGMVTKQLLNVSIPSSVMSISESSCQTSESVPWDGLTI 210
            .|:. :...:.|.|||.||:...:......::      ..|.:......|..:..:..|:.|.:|
Worm   139 SSAYSMLPMRLAVCLPDSCNQHEIIDIFNQLS------PYPFTACHAYCSEYEVKKDTPFWGFSI 197

  Fly   211 FMIVILSVMGSLVALFT--LWDYCLG----KNQDQLPTIVKVFSARVNSRALFRIVEVNSSPNVI 269
            |:||::.:  :|.|..|  :.|...|    |.::....|:..||...|:..|..:.|  ..|..|
Worm   198 FLIVMVVI--ALAASLTDYIRDTVYGIKSIKERNVFLKILLSFSLWTNAELLLSVKE--QKPGFI 258

  Fly   270 DCLHGIRCLSLMWVVFCHQYVMAALASNINIFHAISWEETPYASFILHGFFSVDSFFVLGGLLVA 334
            ..|..||..|:.|||..|.::...|:.  .....|.:.:..:...:|:.|.|||:||||.||::.
Worm   259 KSLDCIRLFSMCWVVTGHSFIYLVLSD--TFMPVIDFPKHFWNHLLLNAFVSVDTFFVLSGLVLT 321

  Fly   335 LIPLRMMDRTKGKLNVP----LMYLHRLIRIVPLLAIAIVMYLKLMPIVADGPRFGSGYSGTV-- 393
            .:..:...:.|..:| |    :.|:||.:|:.|.:.:.|..:....|.: .||...|..:..|
Worm   322 YMFFKTTPKKKMIVN-PVTWIMFYVHRYLRLTPPIMLFIGFFTVYAPYI-QGPFSASQMNQLVME 384

  Fly   394 --DCENGWYWTLLFVNNYTEEK---CLGHTWYLSVDMQLFILSPIMLIALYKWGKKAAAGIFVLI 453
              :|:..|:..||::|::....   |.|.||||:||.||::::||:||.||   ...|.|..:::
Worm   385 ADECKTTWWQNLLYINDFASSNSMGCYGPTWYLAVDTQLYLVAPIVLIGLY---FSFAVGTGLIV 446

  Fly   454 VLLSGCLFAT-IMVNKYSLVLKNFSMDAQKDLYFATHTHATPW------LTGFLFGYSLHLNRGK 511
            ....|.:..| |:.:.|:|....|...:..:  |.|..:..||      |.|.|.||.|.:...:
Worm   447 AGCVGSIITTYILFSVYNLPADMFGNGSGTN--FFTIAYEKPWVRCPPYLVGMLTGYLLAVYGNR 509

  Fly   512 KFQLSKVVAWSGWILCLAMIFTSIFALYPYAKWTGPDLSTFAEASYYTLTRVGWCMALCWVIFAC 576
            |.:|:.|::.:|||:.:.:....:||.|.|.|  |...|.|...::|...|:||.|.:|||:.|.
Worm   510 KIRLNWVLSLAGWIIAVVIAGFCLFATYDYDK--GSHWSVFTRGTFYNFHRLGWGMFICWVVAAN 572

  Fly   577 MNGYGGLANSFLSSPLWQPLSRLSYSVYM--WHMFFQEINIRSMRTNSY-----FSNYTIMLNFW 634
            ..|:||..:.|:|.|:|||..||||..|:  |.:.|..:|:....|:.|     |:..:|...|.
Worm   573 HMGWGGPIDKFMSHPIWQPFGRLSYCAYIVHWVVLFWFLNVGGHATHYYSALEVFTYTSIPATFL 637

  Fly   635 STFGFAVLFAYVMHLVIEAPFGGLDYFL--------RPKQKTPPLVKQKS------QIDDNGHNN 685
            |     .:||:....:.|.|...|:..|        ||..|..|:...|:      :::.||.
Worm   638 S-----YIFAFFWSCLFEIPTLKLEKMLIEAILGTGRPSNKVEPIETGKTTPILEKKLEGNGW-- 695

  Fly   686 LEELK 690
            :||:|
Worm   696 IEEVK 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10182	NP_651158.1	NRF	85..186	CDD:214781	25/108 (23%)
		Acyl_transf_3	269..645	CDD:280013	122/400 (31%)
		OafA	300..655	CDD:224748	114/379 (30%)
oac-14	NP_509701.1	NRF	76..183	CDD:214781	27/123 (22%)
oac-14	NP_509701.1	OafA	252..656	CDD:224748	127/421 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I1719
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I2120
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.680