Protein Alignment Ugt303B2 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 143/569 - (25%)
• Similarity: 262/569 - (46%)
• Gaps: 82/569 - (14%)

  Fly     1 MRLGYAWLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY 65
            ||...:.|.| |||.| ..:..|....:| |:|..: |.:..|:.:::.|:.|||:||::|.:.
Human     1 MRSDKSALVF-LLLQL-FCVGCGFCGKVL-VWPCDM-SHWLNVKVILEELIVRGHEVTVLTHSK- 60

  Fly    66 PAKIDGVR--HIRVPMLNQLMQNLMKNDQFFD-ALG-----DKWREGVLVSTIFYNV-------S 115
            |:.||..:  .::..:::.......:|:.|.| ||.     ..|:..:.::..|..:       .
Human    61 PSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMC 125

  Fly   116 HAILNNNGVQMLMRD-KSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNL- 178
            .:.:.|   |.||:. :...:|::::     |.:....:.. |.||.:..: :|..|. :.||:
Human   126 ESFIYN---QTLMKKLQETNYDVMLI-----DPVIPCGDLM-AELLAVPFV-LTLRIS-VGGNME 179

  Fly   179 -------APSVYEPISPNGFALDNTFLSRWSN---------WIYITEEKLLERLVFRPAQVRLFK 227
                   ||..|.|:...|.....|||.|..|         ||...:....|         ..:.
Human   180 RSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWE---------EFYS 235

  Fly   228 KFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEAE 292
            |..|.|. .|.|...:..:.|:.:::.....:...||...|.|:|..  |.....::..||.|.|
Human   236 KALGRPT-TLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCK--PAKALPKINFYLQEME 297

  Fly   293 H--------GAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDK 349
            :        |.:.||:|.  |.:.:.|.....:.....|:.|:|:|:.:....:....|..:.|.
Human   298 NFVQSSGEDGIVVFSLGS--LFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDW 360

  Fly   350 VPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLN 414
            :||..:|.||..:.||||||:..:.|||.:||||:|:|:|.||.:||..::..|.|..::...:.
Human   361 IPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMT 425

  Fly   415 ADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLM 479
            ::.|:..::.::.:.||.:.|..::....|:|:.|||.|::|.|:.:|::...|:|....::...
Human   426 SEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWF 490

  Fly   480 RYYRLDSILTFGVRLGCVCGSLIFLGWRLY----QK-NRNRHTRLQERE 523
            ::|.:|.|   |..|.|| .:.|||..:.:    || |:.|  ::::||
Human   491 QHYSIDVI---GFLLACV-ATAIFLFTKCFLFSCQKFNKTR--KIEKRE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	116/480 (24%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	132/537 (25%)