DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	536	Identity:	136/536 - (25%)
Similarity:	245/536 - (45%)	Gaps:	71/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKIDGVRH---------- 74
            :::|.:..:| |.|... |.:..:||:|:|||::.|.||::..:..|.    |.|
Zfish    15 VDVGWSGRVL-VMPGEY-SHWHNMRPVIEALVDKNHSVTVLVGSSSPT----VPHTQKERFEYHV 73

  Fly    75 IRVPMLNQLM-------QNLMKNDQF--FDALGDKWR--------EGVLVSTIFYNVSHAILNNN 122
            .:|.|..:::       ..|..|:..  ::...:.|:        ...||..:|.......|.::
Zfish    74 FKVNMEKEVVDYLWIHFHELWMNETISTYEKTLEVWQLMSLFRAHSEELVKGLFDVGLLKTLRDS 138

  Fly   123 GVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNL-APSVYEPI 186
            ...:|..|.::.|..:|.:..::..:..:...:.:.|            :.|.|.: .|..|.|.
Zfish   139 NYDVLFSDLTMPFSDLMAQKLNIPHVLSMRISFASAL------------ERLCGQMPVPQSYVPA 191

  Fly   187 S-PNGFALDN-TFLSRWSNW-IYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVIL 248
            : ..|...|. :|..|..|. :|||...:.: |..:.....::.:..|.|....:.: .:..:.|
Zfish   192 AVAQGHLTDRMSFTERVENMLLYITHTAMFQ-LTTKFTFDHIYAEISGEPTTMCETI-GKTDIWL 254

  Fly   249 VNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPEN 312
            :.:::.....|...||...|.|:. .:|.:|...||::::..: :||.:.||:|.  :||.|...
Zfish   255 IRTYWDFEYPRPFPPNFKFVGGLQ-CKPAKPLAKELEEFVQSSGDHGIVVFSLGS--MIKNLTVQ 316

  Fly   313 MQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAI 377
            ....:.....|:.|:|:|:.........:.|..:.|.:||..:|.||..:.||||||...:.|||
Zfish   317 KANTIAAALGQISQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAI 381

  Fly   378 DNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASF 442
            .:||||:|||||.||.:|:..::..|.|.|||...|.:..|::.:|.:|.||||.:....::...
Zfish   382 YHGVPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLNNPSYKESIMRLSRIH 446

  Fly   443 RDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLD---------SILTF-GVRLGCV 497
            .|:||.|||.|::|.|:.:||:...|:|:...|:...:|:.||         :::|| .|:..|
Zfish   447 HDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACC- 510

  Fly   498 CGSLIFLGWRLYQKNR 513
                 ||..|..:|.|
Zfish   511 -----FLFRRCVRKTR 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	119/471 (25%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	133/526 (25%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	77/233 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830